ID   ERH_DANRE               Reviewed;         104 AA.
AC   Q98874; Q6IQH5;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Enhancer of rudimentary homolog;
GN   Name=erh; Synonyms=e(r); ORFNames=zgc:86761;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9074495; DOI=10.1016/s0378-1119(96)00701-9;
RA   Gelsthorpe M., Pulumati M., McCallum C., Dang-Vu K., Tsubota S.I.;
RT   "The putative cell cycle gene, enhancer of rudimentary, encodes a highly
RT   conserved protein found in plants and animals.";
RL   Gene 186:189-195(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo, and Retina;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May have a role in the cell cycle. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P84090}.
CC   -!- SIMILARITY: Belongs to the E(R) family. {ECO:0000305}.
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DR   EMBL; U66872; AAC60097.1; -; mRNA.
DR   EMBL; AL929220; CAI21198.1; -; Genomic_DNA.
DR   EMBL; BC059528; AAH59528.1; -; mRNA.
DR   EMBL; BC071431; AAH71431.1; -; mRNA.
DR   RefSeq; NP_001258746.1; NM_001271817.1.
DR   AlphaFoldDB; Q98874; -.
DR   SMR; Q98874; -.
DR   STRING; 7955.ENSDARP00000092749; -.
DR   PaxDb; Q98874; -.
DR   PRIDE; Q98874; -.
DR   Ensembl; ENSDART00000101974; ENSDARP00000092749; ENSDARG00000032866.
DR   GeneID; 30475; -.
DR   KEGG; dre:30475; -.
DR   CTD; 2079; -.
DR   ZFIN; ZDB-GENE-990415-57; erh.
DR   eggNOG; KOG1766; Eukaryota.
DR   GeneTree; ENSGT00390000003316; -.
DR   HOGENOM; CLU_125703_1_0_1; -.
DR   InParanoid; Q98874; -.
DR   OMA; RTWSDYE; -.
DR   OrthoDB; 1512482at2759; -.
DR   PhylomeDB; Q98874; -.
DR   TreeFam; TF314568; -.
DR   PRO; PR:Q98874; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 20.
DR   Bgee; ENSDARG00000032866; Expressed in early embryo and 28 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2260.10; -; 1.
DR   InterPro; IPR035912; EHR_sf.
DR   InterPro; IPR000781; ERH.
DR   PANTHER; PTHR12373; PTHR12373; 1.
DR   Pfam; PF01133; ER; 1.
DR   PIRSF; PIRSF016393; Enh_rudimentary; 1.
DR   SUPFAM; SSF143875; SSF143875; 1.
DR   PROSITE; PS01290; ER; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Nucleus; Reference proteome.
FT   CHAIN           1..104
FT                   /note="Enhancer of rudimentary homolog"
FT                   /id="PRO_0000219353"
FT   CONFLICT        82
FT                   /note="Y -> C (in Ref. 3; AAH71431)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   104 AA;  12245 MW;  C609AFEEDE9CC179 CRC64;
     MSHTILLVQP TKRPEGRTYA DYESVNECME GVCKMYEEHL KRMNPNSPSI TYDISQLFDF
     VDDLADLSCL VYRADTQTYQ PYNKDWIKEK IYVLLRRQAQ QAGK