ID   ERI2_DANRE              Reviewed;         555 AA.
AC   Q502M8;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=ERI1 exoribonuclease 2;
DE            EC=3.1.-.-;
DE   AltName: Full=Exonuclease domain-containing protein 1;
GN   Name=eri2; Synonyms=exod1; ORFNames=zgc:111991;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC       Note=Binds 2 magnesium ions per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the ERI2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC095637; AAH95637.1; -; mRNA.
DR   RefSeq; NP_001018476.1; NM_001020640.1.
DR   AlphaFoldDB; Q502M8; -.
DR   SMR; Q502M8; -.
DR   STRING; 7955.ENSDARP00000054440; -.
DR   GeneID; 553667; -.
DR   KEGG; dre:553667; -.
DR   CTD; 112479; -.
DR   ZFIN; ZDB-GENE-050522-292; eri2.
DR   eggNOG; KOG0542; Eukaryota.
DR   InParanoid; Q502M8; -.
DR   OrthoDB; 809000at2759; -.
DR   PhylomeDB; Q502M8; -.
DR   PRO; PR:Q502M8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR010666; Znf_GRF.
DR   Pfam; PF00929; RNase_T; 1.
DR   Pfam; PF06839; zf-GRF; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   2: Evidence at transcript level;
KW   Exonuclease; Hydrolase; Magnesium; Metal-binding; Nuclease;
KW   Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..555
FT                   /note="ERI1 exoribonuclease 2"
FT                   /id="PRO_0000338975"
FT   DOMAIN          35..222
FT                   /note="Exonuclease"
FT   ZN_FING         486..531
FT                   /note="GRF-type"
FT   REGION          266..319
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        266..297
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        41
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        209
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255"
FT   BINDING         39
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         39
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         41
FT                   /ligand="AMP"
FT                   /ligand_id="ChEBI:CHEBI:456215"
FT                   /evidence="ECO:0000250"
FT   BINDING         41
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         152
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         209
FT                   /ligand="AMP"
FT                   /ligand_id="ChEBI:CHEBI:456215"
FT                   /evidence="ECO:0000250"
FT   BINDING         214
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   555 AA;  61646 MW;  1DA930A4D2A3733A CRC64;
     MTTKRLAKEL GLLRQRSASS SAQRSSVCKQ RFSFLIIIDF ESTCWREKSS SGQEIIEFPA
     VLLSVCSGAV ESEFHSYVQP QERPVLSAFC TELTGITQDQ VDSAPPLHVV LSRFSRWLRS
     LQEERGVVFL TDSSGAAPSA QLCAFVTWSD WDLGVCLLYE CKRKQLSVPE ALKNWIDLRA
     TYKLFYNRKP KGLRGALLDL GIEFTGREHS GLVDARNTAL LAQRMMTDGC QLSITSPERR
     AQVKPRPHTR PSGLRERHTH LTNVKNSRDT HTNTNTHLTN VKNSRDTHTN THTHLTSVKN
     TRDTHTHTNT HLTNVKSSRD AHTRLPALMN GSIRARHTHT QQTCANSSDT HIASASVCEV
     LVSPYTLLSV AHTHTHLQAR SAALAGLSDT TYDPESPAPC WQDGELLVEE EEPSSYDDVI
     LGAEPEEATP SEPRRCVSSS VFKTPPPLLR SGPLSPLTHS LGRIAAPLSV HAHTHALKQK
     VKVTSPLCVC GRRARRLTVG NGGPNHGRVF YCCPRRRSNT HTHTCDFFQW ESGVLQNTLS
     MLTTHTPAAA HTHLR