ERI2_HUMAN
ID ERI2_HUMAN Reviewed; 691 AA.
AC A8K979; Q6ZSJ2; Q96FR9; Q9P224; Q9Y6V3;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=ERI1 exoribonuclease 2;
DE EC=3.1.-.-;
DE AltName: Full=Exonuclease domain-containing protein 1;
GN Name=ERI2; Synonyms=EXOD1, KIAA1504;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Testis, and Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10493829; DOI=10.1006/geno.1999.5927;
RA Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J.,
RA Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X.,
RA Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C.,
RA Adams M.D.;
RT "Genome duplications and other features in 12 Mb of DNA sequence from human
RT chromosome 16p and 16q.";
RL Genomics 60:295-308(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 245-691.
RX PubMed=10819331; DOI=10.1093/dnares/7.2.143;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:143-150(2000).
RN [5]
RP VARIANT [LARGE SCALE ANALYSIS] THR-206.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC Note=Binds 2 magnesium ions per subunit. {ECO:0000250};
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=A8K979-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A8K979-2; Sequence=VSP_034077;
CC Name=3;
CC IsoId=A8K979-3; Sequence=VSP_034079, VSP_034080;
CC Name=4;
CC IsoId=A8K979-4; Sequence=VSP_034078, VSP_034081;
CC -!- SIMILARITY: Belongs to the ERI2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC31669.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK127391; BAC86956.1; -; mRNA.
DR EMBL; AK292594; BAF85283.1; -; mRNA.
DR EMBL; AC004381; AAC31669.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC010503; AAH10503.1; -; mRNA.
DR EMBL; AB040937; BAA96028.1; -; mRNA.
DR CCDS; CCDS10590.1; -. [A8K979-4]
DR CCDS; CCDS45436.1; -. [A8K979-1]
DR RefSeq; NP_001136197.1; NM_001142725.1. [A8K979-1]
DR RefSeq; NP_542394.2; NM_080663.2. [A8K979-4]
DR AlphaFoldDB; A8K979; -.
DR SMR; A8K979; -.
DR BioGRID; 125189; 4.
DR IntAct; A8K979; 5.
DR MINT; A8K979; -.
DR STRING; 9606.ENSP00000350651; -.
DR iPTMnet; A8K979; -.
DR PhosphoSitePlus; A8K979; -.
DR BioMuta; ERI2; -.
DR EPD; A8K979; -.
DR jPOST; A8K979; -.
DR MassIVE; A8K979; -.
DR MaxQB; A8K979; -.
DR PaxDb; A8K979; -.
DR PeptideAtlas; A8K979; -.
DR PRIDE; A8K979; -.
DR ProteomicsDB; 1893; -. [A8K979-1]
DR ProteomicsDB; 1894; -. [A8K979-2]
DR Antibodypedia; 25615; 115 antibodies from 18 providers.
DR DNASU; 112479; -.
DR Ensembl; ENST00000300005.7; ENSP00000300005.3; ENSG00000196678.14. [A8K979-4]
DR Ensembl; ENST00000357967.9; ENSP00000350651.4; ENSG00000196678.14. [A8K979-1]
DR Ensembl; ENST00000563117.5; ENSP00000454661.1; ENSG00000196678.14. [A8K979-2]
DR Ensembl; ENST00000564349.5; ENSP00000455982.1; ENSG00000196678.14. [A8K979-2]
DR Ensembl; ENST00000569729.5; ENSP00000457488.1; ENSG00000196678.14. [A8K979-3]
DR GeneID; 112479; -.
DR KEGG; hsa:112479; -.
DR MANE-Select; ENST00000357967.9; ENSP00000350651.4; NM_001142725.2; NP_001136197.1.
DR UCSC; uc002dhs.3; human. [A8K979-1]
DR CTD; 112479; -.
DR DisGeNET; 112479; -.
DR GeneCards; ERI2; -.
DR HGNC; HGNC:30541; ERI2.
DR HPA; ENSG00000196678; Low tissue specificity.
DR neXtProt; NX_A8K979; -.
DR OpenTargets; ENSG00000196678; -.
DR PharmGKB; PA164719245; -.
DR VEuPathDB; HostDB:ENSG00000196678; -.
DR eggNOG; KOG0542; Eukaryota.
DR GeneTree; ENSGT00530000063205; -.
DR HOGENOM; CLU_037266_4_0_1; -.
DR InParanoid; A8K979; -.
DR OMA; CRELTHI; -.
DR OrthoDB; 809000at2759; -.
DR PhylomeDB; A8K979; -.
DR TreeFam; TF313449; -.
DR PathwayCommons; A8K979; -.
DR SignaLink; A8K979; -.
DR BioGRID-ORCS; 112479; 14 hits in 1078 CRISPR screens.
DR ChiTaRS; ERI2; human.
DR GenomeRNAi; 112479; -.
DR Pharos; A8K979; Tbio.
DR PRO; PR:A8K979; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; A8K979; protein.
DR Bgee; ENSG00000196678; Expressed in oocyte and 183 other tissues.
DR ExpressionAtlas; A8K979; baseline and differential.
DR Genevisible; A8K979; HS.
DR GO; GO:0000175; F:3'-5'-exoribonuclease activity; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR Gene3D; 3.30.420.10; -; 1.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR010666; Znf_GRF.
DR Pfam; PF00929; RNase_T; 1.
DR Pfam; PF06839; zf-GRF; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Exonuclease; Hydrolase; Magnesium; Metal-binding;
KW Nuclease; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..691
FT /note="ERI1 exoribonuclease 2"
FT /id="PRO_0000338973"
FT DOMAIN 37..226
FT /note="Exonuclease"
FT ZN_FING 595..642
FT /note="GRF-type"
FT ACT_SITE 43
FT /note="Proton acceptor"
FT /evidence="ECO:0000255"
FT ACT_SITE 213
FT /note="Proton acceptor"
FT /evidence="ECO:0000255"
FT BINDING 41
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 41
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 43
FT /ligand="AMP"
FT /ligand_id="ChEBI:CHEBI:456215"
FT /evidence="ECO:0000250"
FT BINDING 43
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 156
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 213
FT /ligand="AMP"
FT /ligand_id="ChEBI:CHEBI:456215"
FT /evidence="ECO:0000250"
FT BINDING 218
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..93
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034077"
FT VAR_SEQ 245..328
FT /note="VPTKKNFSILARNLNTIQVEEMSACNISIQGPSIYNKEPKNIINPHEKVQMK
FT SICANSPIKAQQDQLQVKNNIKASLHNVKSSL -> GPFLLPSWTWNSDLASGDQHAFL
FT QQEFGCGTYRTLLQKPNMSKQEKGNILWLTMVWLSLACLQRKNYNDCMLNTASQTVTTE
FT KF (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034078"
FT VAR_SEQ 246..279
FT /note="PTKKNFSILARNLNTIQVEEMSACNISIQGPSIY -> VPKGIHAVPKLSHQ
FT QKNNPSLFMKKSLHHLIAPQ (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034079"
FT VAR_SEQ 280..691
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034080"
FT VAR_SEQ 329..691
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034081"
FT VARIANT 206
FT /note="I -> T (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs997506328)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_043848"
FT CONFLICT 352
FT /note="Y -> C (in Ref. 4; BAA96028)"
FT /evidence="ECO:0000305"
FT VARIANT A8K979-4:268
FT /note="Q -> K (in dbSNP:rs17850670)"
FT /evidence="ECO:0000305"
FT /id="VAR_082819"
FT VARIANT A8K979-4:272
FT /note="G -> E (in dbSNP:rs2301770)"
FT /evidence="ECO:0000305"
FT /id="VAR_082820"
SQ SEQUENCE 691 AA; 77401 MW; 3A0DA36ABDDAA36D CRC64;
MATKRLARQL GLIRRKSIAP ANGNLGRSKS KQLFDYLIVI DFESTCWNDG KHHHSQEIIE
FPAVLLNTST GQIDSEFQAY VQPQEHPILS EFCMELTGIK QAQVDEGVPL KICLSQFCKW
IHKIQQQKNI IFATGISEPS ASEVKLCAFV TWSDWDLGVC LEYECKRKQL LKPVFLNSWI
DLRATYKLFY RRKPKGLSGA LQEVGIEFSG REHSGLDDSR NTALLAWKMI RDGCVMKITR
SLNKVPTKKN FSILARNLNT IQVEEMSACN ISIQGPSIYN KEPKNIINPH EKVQMKSICA
NSPIKAQQDQ LQVKNNIKAS LHNVKSSLPL FNTKSSTSVG QLQSPTLNSP IYMQKQGKNE
HLAFNTKSKA STVGSELVLV STTVPTVHHV SDLEMSSTLD CLPVLADWED VVLLPASQPE
ENVDCTVPIS DSDLEISFNS GERLMVLKEL EMSSHENFGD IEETPQKSET SKSIVYKSPH
TTIYNVKEAK DPGSDISAFK LPEHKSSTFN RVNANMSHPL VLGKHPLLSG GTKRNPCSPQ
AFPPAKKQPF TIHEEKPTSS DCSPVRSSSW RRLPSILTST VNLQEPWKSG KMTPPLCKCG
RRSKRLVVSN NGPNHGKVFY CCPIGKYQEN RKCCGYFKWE QTLQKERANS MVPSHSTGGL
TFSSPETSHI CDRNLSISTK NSLRLRPSMR N
