ERI2_MOUSE
ID ERI2_MOUSE Reviewed; 688 AA.
AC Q5BKS4; Q3TUK9; Q8C133;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=ERI1 exoribonuclease 2;
DE EC=3.1.-.-;
DE AltName: Full=Exonuclease domain-containing protein 1;
GN Name=Eri2; Synonyms=Exod1, Kiaa1504;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head, and Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC Note=Binds 2 magnesium ions per subunit. {ECO:0000250};
CC -!- SIMILARITY: Belongs to the ERI2 family. {ECO:0000305}.
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DR EMBL; AK029056; BAC26269.1; -; mRNA.
DR EMBL; AK135821; BAE22676.1; -; mRNA.
DR EMBL; AK160698; BAE35962.1; -; mRNA.
DR EMBL; AK165163; BAE38055.1; -; mRNA.
DR EMBL; BC090961; AAH90961.1; -; mRNA.
DR CCDS; CCDS40107.1; -.
DR RefSeq; NP_081974.3; NM_027698.5.
DR AlphaFoldDB; Q5BKS4; -.
DR SMR; Q5BKS4; -.
DR STRING; 10090.ENSMUSP00000120547; -.
DR iPTMnet; Q5BKS4; -.
DR PhosphoSitePlus; Q5BKS4; -.
DR EPD; Q5BKS4; -.
DR PaxDb; Q5BKS4; -.
DR PRIDE; Q5BKS4; -.
DR ProteomicsDB; 275780; -.
DR Antibodypedia; 25615; 115 antibodies from 18 providers.
DR DNASU; 71151; -.
DR Ensembl; ENSMUST00000150844; ENSMUSP00000120547; ENSMUSG00000030929.
DR GeneID; 71151; -.
DR KEGG; mmu:71151; -.
DR UCSC; uc009jlu.2; mouse.
DR CTD; 112479; -.
DR MGI; MGI:1918401; Eri2.
DR VEuPathDB; HostDB:ENSMUSG00000030929; -.
DR eggNOG; KOG0542; Eukaryota.
DR GeneTree; ENSGT00530000063205; -.
DR HOGENOM; CLU_025844_0_0_1; -.
DR InParanoid; Q5BKS4; -.
DR OrthoDB; 809000at2759; -.
DR PhylomeDB; Q5BKS4; -.
DR TreeFam; TF313449; -.
DR BioGRID-ORCS; 71151; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Eri2; mouse.
DR PRO; PR:Q5BKS4; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q5BKS4; protein.
DR Bgee; ENSMUSG00000030929; Expressed in metanephric proximal tubule and 221 other tissues.
DR ExpressionAtlas; Q5BKS4; baseline and differential.
DR Genevisible; Q5BKS4; MM.
DR GO; GO:0000175; F:3'-5'-exoribonuclease activity; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR Gene3D; 3.30.420.10; -; 1.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR010666; Znf_GRF.
DR Pfam; PF00929; RNase_T; 1.
DR Pfam; PF06839; zf-GRF; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
PE 2: Evidence at transcript level;
KW Exonuclease; Hydrolase; Magnesium; Metal-binding; Nuclease;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..688
FT /note="ERI1 exoribonuclease 2"
FT /id="PRO_0000338974"
FT DOMAIN 37..226
FT /note="Exonuclease"
FT ZN_FING 592..639
FT /note="GRF-type"
FT REGION 337..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..545
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 43
FT /note="Proton acceptor"
FT /evidence="ECO:0000255"
FT ACT_SITE 213
FT /note="Proton acceptor"
FT /evidence="ECO:0000255"
FT BINDING 41
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 41
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 43
FT /ligand="AMP"
FT /ligand_id="ChEBI:CHEBI:456215"
FT /evidence="ECO:0000250"
FT BINDING 43
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 156
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 213
FT /ligand="AMP"
FT /ligand_id="ChEBI:CHEBI:456215"
FT /evidence="ECO:0000250"
FT BINDING 218
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT CONFLICT 232
FT /note="D -> N (in Ref. 1; BAC26269)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 688 AA; 76524 MW; 7D11330D3D27AB70 CRC64;
MATKRLARRL GLIRRKSVTP ASGNPGGSRL KQLYAYLIVV DFESTCWNDG KHHSSPEIIE
FPAVLLNTAT GEIESEFHAY VQPQEHPILS EFCTELTGIK QVQVDEGVPL KICLSQFCKW
IHKLQQQQTI SFAAGDSEPS TSEVKLCAFV TWSDWDLGVC LEYECRRKQL LKPVFLNSWI
DLRATYRLFY KRKPKGLSGA LQEVGIEFSG REHSGLDDSR NTALLAWKMI RDGCLMKITR
SLNKVLTKKN PKILARNLGT DQVEEAATCN MSIQGPSIYQ KELQSTVNAE ENAQMNSVCV
NSSCIKGQLQ PKSNMKADLY NIRHSFPLFT TKSSTSVDQL HSPTLNPPLT MQKPSKSDQL
ALNDSSKSST LNSNLVLVST TIPSVNHVSD VEMGHTFDCL PMLAEWEDVV LLPASQAEPD
TDCMPPVSDT NVSTSLNSAE RSLVPEEPET LSYENFEDLQ ETPQNSETSK SIVYKSPHST
VYDVKGAKHP GSDASAFKLP KCKPFPFTSV HASAAYPSVL RKDPLLSGGT KRNSLSPPAS
PRTKRQTFTI HEEKPTSSIC SPGTTSCRVS PSVLTSTVNL QEPWKTGKMT PPLCKCGRRS
KRLIVSNNGP NHGKAFYCCP VGKYQQDRKC CGYFKWEQTL QKERTNGKAL SHSSEGLTFS
SPETSRIHDR NLSFPIKNSL RLRPSMRH
