ID   ERI2_XENLA              Reviewed;         687 AA.
AC   Q5HZL1;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=ERI1 exoribonuclease 2;
DE            EC=3.1.-.-;
DE   AltName: Full=Exonuclease domain-containing protein 1;
GN   Name=eri2; Synonyms=exod1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC       Note=Binds 2 magnesium ions per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the ERI2 family. {ECO:0000305}.
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DR   EMBL; BC088972; AAH88972.1; -; mRNA.
DR   RefSeq; NP_001089039.1; NM_001095570.1.
DR   AlphaFoldDB; Q5HZL1; -.
DR   SMR; Q5HZL1; -.
DR   DNASU; 503681; -.
DR   GeneID; 503681; -.
DR   KEGG; xla:503681; -.
DR   CTD; 503681; -.
DR   Xenbase; XB-GENE-970831; eri2.L.
DR   OrthoDB; 809000at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 503681; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR010666; Znf_GRF.
DR   Pfam; PF00929; RNase_T; 1.
DR   Pfam; PF06839; zf-GRF; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   2: Evidence at transcript level;
KW   Exonuclease; Hydrolase; Magnesium; Metal-binding; Nuclease;
KW   Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..687
FT                   /note="ERI1 exoribonuclease 2"
FT                   /id="PRO_0000338976"
FT   DOMAIN          38..226
FT                   /note="Exonuclease"
FT   ZN_FING         593..641
FT                   /note="GRF-type"
FT   ACT_SITE        44
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        213
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255"
FT   BINDING         42
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         42
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         44
FT                   /ligand="AMP"
FT                   /ligand_id="ChEBI:CHEBI:456215"
FT                   /evidence="ECO:0000250"
FT   BINDING         44
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         156
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         213
FT                   /ligand="AMP"
FT                   /ligand_id="ChEBI:CHEBI:456215"
FT                   /evidence="ECO:0000250"
FT   BINDING         218
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   687 AA;  75840 MW;  1B2874CC37565E1B CRC64;
     MATKQLAKQL GLIRRSSKTS QTSSNVSRPK ARQFFEYLII IDFESTCWKD GKHSTQEIIE
     FPAVLLNVSN GEIESEFHTY VQPQEHPILS DFCTELTGIN QQQVDDGVPL KICLSQFNSW
     IQKLQKEKGI AFVTAVPTHS TAEHKMCAFV TWSDWDLGVC LLYECRRKQM KKPDILNSWI
     DLRATYKLFY NRRPKGLNGA LQDLGIEFSG REHSGLDDSR NTAKLASRMI CDGCVMKITK
     SLDKVNHKIS YTRPQQVLPA QDSNSVQVGT IQTSEMHSEK NPQPSFDKTA ACVNVMNLQK
     DLEPSSLKIN GKPIGRDKAV TMLNGHQGQE SLPSQTLING LSTTLGNGPK RCFTNRTSLG
     TLQTGVSLGA FTSTPAELPS LGSGHVLMST TVTSVTDISA LDISSTSDCL SMLADWEDAA
     VIEDSQEEPS VPTTEQSDLL MAQTSVDVTL PGTNMANCNR NQKYGSFHPH SIAYQSRNTT
     IYNINVKQNV SSCSTFKVPG VLARRSTNMM PTSAQLNKMS TSLPSFPKRK LSSVSFYSPP
     KKQPFIIHED KCSSNNRSLP VISSRPHNVP PTVLNATVNN TFKSAQTGKI TAPMCNCGRR
     AKRLTVSNAG PNQGKAFYTC SVKKRNEENK KGCDYFKWEQ TVVKEKSAQS TIILSKSGIS
     FSSNTSFTAA NSASRRSFVS LRPSMRT