AGRA3_HUMAN
ID AGRA3_HUMAN Reviewed; 1321 AA.
AC Q8IWK6; Q6UXK9; Q86SQ5; Q8TC55;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=Adhesion G protein-coupled receptor A3 {ECO:0000303|PubMed:25713288};
DE AltName: Full=G-protein coupled receptor 125;
DE Flags: Precursor;
GN Name=ADGRA3 {ECO:0000312|HGNC:HGNC:13839}; Synonyms=GPR125;
GN ORFNames=UNQ556/PRO1113;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RX PubMed=12565841; DOI=10.1016/s0006-291x(03)00026-3;
RA Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C.,
RA Schioeth H.B.;
RT "There exist at least 30 human G-protein-coupled receptors with long
RT Ser/Thr-rich N-termini.";
RL Biochem. Biophys. Res. Commun. 301:725-734(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
RC TISSUE=Eye, and Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP INTERACTION WITH DLG1.
RX PubMed=15021905; DOI=10.1038/sj.onc.1207495;
RA Yamamoto Y., Irie K., Asada M., Mino A., Mandai K., Takai Y.;
RT "Direct binding of the human homologue of the Drosophila disc large tumor
RT suppressor gene to seven-pass transmembrane proteins, tumor endothelial
RT marker 5 (TEM5), and a novel TEM5-like protein.";
RL Oncogene 23:3889-3897(2004).
RN [6]
RP NOMENCLATURE.
RX PubMed=25713288; DOI=10.1124/pr.114.009647;
RA Hamann J., Aust G., Arac D., Engel F.B., Formstone C., Fredriksson R.,
RA Hall R.A., Harty B.L., Kirchhoff C., Knapp B., Krishnan A., Liebscher I.,
RA Lin H.H., Martinelli D.C., Monk K.R., Peeters M.C., Piao X., Promel S.,
RA Schoneberg T., Schwartz T.W., Singer K., Stacey M., Ushkaryov Y.A.,
RA Vallon M., Wolfrum U., Wright M.W., Xu L., Langenhan T., Schioth H.B.;
RT "International union of basic and clinical pharmacology. XCIV. Adhesion G
RT protein-coupled receptors.";
RL Pharmacol. Rev. 67:338-367(2015).
CC -!- FUNCTION: Orphan receptor that may have a role in planar cell polarity
CC pathway. {ECO:0000250|UniProtKB:S4X0Q8}.
CC -!- SUBUNIT: Interacts (via PDZ-binding motif) with DLG1.
CC {ECO:0000269|PubMed:15021905}.
CC -!- INTERACTION:
CC Q8IWK6-3; Q12959-2: DLG1; NbExp=2; IntAct=EBI-10949249, EBI-357500;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:S4X0Q8}; Multi-
CC pass membrane protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8IWK6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IWK6-2; Sequence=VSP_010741, VSP_010742;
CC Name=3;
CC IsoId=Q8IWK6-3; Sequence=VSP_010738, VSP_010740;
CC Name=4;
CC IsoId=Q8IWK6-4; Sequence=VSP_010743, VSP_010744, VSP_010745,
CC VSP_010746;
CC -!- MISCELLANEOUS: Most adhesion GPCRs proteins undergo autoproteolysis at
CC the GPS domain. ADGRA3 is predicted non-cleavable because of the lack
CC of a consensus catalytic triad sequence within GPS domain.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH35645.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY181243; AAO27355.1; -; mRNA.
DR EMBL; AY358306; AAQ88673.1; -; mRNA.
DR EMBL; AC093735; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC093814; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC026009; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC035645; AAH35645.1; ALT_SEQ; mRNA.
DR CCDS; CCDS33964.1; -. [Q8IWK6-1]
DR RefSeq; NP_660333.2; NM_145290.3. [Q8IWK6-1]
DR AlphaFoldDB; Q8IWK6; -.
DR SMR; Q8IWK6; -.
DR BioGRID; 127930; 30.
DR IntAct; Q8IWK6; 5.
DR MINT; Q8IWK6; -.
DR STRING; 9606.ENSP00000334952; -.
DR ChEMBL; CHEMBL4523887; -.
DR MEROPS; P02.018; -.
DR GlyGen; Q8IWK6; 13 sites.
DR iPTMnet; Q8IWK6; -.
DR PhosphoSitePlus; Q8IWK6; -.
DR BioMuta; ADGRA3; -.
DR DMDM; 50400542; -.
DR EPD; Q8IWK6; -.
DR MassIVE; Q8IWK6; -.
DR PaxDb; Q8IWK6; -.
DR PeptideAtlas; Q8IWK6; -.
DR PRIDE; Q8IWK6; -.
DR ProteomicsDB; 70864; -. [Q8IWK6-1]
DR ProteomicsDB; 70865; -. [Q8IWK6-2]
DR ProteomicsDB; 70866; -. [Q8IWK6-3]
DR ProteomicsDB; 70867; -. [Q8IWK6-4]
DR Antibodypedia; 1933; 172 antibodies from 31 providers.
DR DNASU; 166647; -.
DR Ensembl; ENST00000334304.10; ENSP00000334952.5; ENSG00000152990.14. [Q8IWK6-1]
DR Ensembl; ENST00000502482.1; ENSP00000421006.1; ENSG00000152990.14. [Q8IWK6-2]
DR Ensembl; ENST00000508133.5; ENSP00000422606.1; ENSG00000152990.14. [Q8IWK6-4]
DR GeneID; 166647; -.
DR KEGG; hsa:166647; -.
DR MANE-Select; ENST00000334304.10; ENSP00000334952.5; NM_145290.4; NP_660333.2.
DR UCSC; uc003gqm.3; human. [Q8IWK6-1]
DR CTD; 166647; -.
DR DisGeNET; 166647; -.
DR GeneCards; ADGRA3; -.
DR HGNC; HGNC:13839; ADGRA3.
DR HPA; ENSG00000152990; Tissue enhanced (liver).
DR MalaCards; ADGRA3; -.
DR MIM; 612303; gene.
DR neXtProt; NX_Q8IWK6; -.
DR OpenTargets; ENSG00000152990; -.
DR PharmGKB; PA134919579; -.
DR VEuPathDB; HostDB:ENSG00000152990; -.
DR eggNOG; KOG0619; Eukaryota.
DR eggNOG; KOG4237; Eukaryota.
DR GeneTree; ENSGT00940000157235; -.
DR HOGENOM; CLU_005242_1_0_1; -.
DR InParanoid; Q8IWK6; -.
DR OMA; TYIYHHS; -.
DR OrthoDB; 31536at2759; -.
DR PhylomeDB; Q8IWK6; -.
DR TreeFam; TF331206; -.
DR PathwayCommons; Q8IWK6; -.
DR SignaLink; Q8IWK6; -.
DR BioGRID-ORCS; 166647; 6 hits in 1076 CRISPR screens.
DR ChiTaRS; ADGRA3; human.
DR GeneWiki; GPR125; -.
DR GenomeRNAi; 166647; -.
DR Pharos; Q8IWK6; Tbio.
DR PRO; PR:Q8IWK6; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q8IWK6; protein.
DR Bgee; ENSG00000152990; Expressed in ventricular zone and 182 other tissues.
DR ExpressionAtlas; Q8IWK6; baseline and differential.
DR Genevisible; Q8IWK6; HS.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; TAS:GDB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; TAS:GDB.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:GDB.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR Gene3D; 4.10.1240.10; -; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF111418; SSF111418; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; G-protein coupled receptor;
KW Glycoprotein; Immunoglobulin domain; Leucine-rich repeat; Membrane;
KW Receptor; Reference proteome; Repeat; Signal; Transducer; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT CHAIN 34..1321
FT /note="Adhesion G protein-coupled receptor A3"
FT /id="PRO_0000012900"
FT TOPO_DOM 34..761
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 762..782
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 783..796
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 797..817
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 818..826
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 827..847
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 848..876
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 877..897
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 898..919
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 920..940
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 941..996
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 997..1017
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1018..1024
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 1025..1045
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1046..1321
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT REPEAT 82..103
FT /note="LRR 1"
FT REPEAT 106..127
FT /note="LRR 2"
FT REPEAT 130..151
FT /note="LRR 3"
FT REPEAT 154..175
FT /note="LRR 4"
FT DOMAIN 187..237
FT /note="LRRCT"
FT DOMAIN 242..340
FT /note="Ig-like"
FT REPEAT 594..620
FT /note="LRR 5"
FT DOMAIN 698..749
FT /note="GPS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00098"
FT REGION 1073..1094
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1198..1219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1231..1265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1294..1321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 1319..1321
FT /note="PDZ-binding"
FT /evidence="ECO:0000255"
FT COMPBIAS 1198..1213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1232..1256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 81
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 98
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 206
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 301
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 332
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 433
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 453
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 592
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 652
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 687
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 728
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 821
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 264..324
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 1..134
FT /note="MEPPGRRRGRAQPPLLLPLSLLALLALLGGGGGGGAAALPAGCKHDGRPRGA
FT GRAAGAAEGKVVCSSLELAQVLPPDTLPNRTVTLILSNNKISELKNGSFSGLSLLERLD
FT LRNNLISSIDPGAFWGLSSLKRL -> MMRVMPCQV (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12565841"
FT /id="VSP_010738"
FT VAR_SEQ 1..10
FT /note="MEPPGRRRGR -> MPLKRNNSKY (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_010743"
FT VAR_SEQ 11..236
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_010744"
FT VAR_SEQ 603..620
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12565841"
FT /id="VSP_010740"
FT VAR_SEQ 604..616
FT /note="NTIVEASIQLPPS -> VCYILQSFKTIYS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_010741"
FT VAR_SEQ 604..607
FT /note="NTIV -> GKFR (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_010745"
FT VAR_SEQ 608..1321
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_010746"
FT VAR_SEQ 617..1321
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_010742"
FT VARIANT 1043
FT /note="V -> M (in dbSNP:rs9002)"
FT /id="VAR_033971"
FT VARIANT 1166
FT /note="V -> G (in dbSNP:rs3814416)"
FT /id="VAR_033972"
FT CONFLICT 537
FT /note="S -> P (in Ref. 4; BC026009)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1321 AA; 146151 MW; 25EBC1620E1895EA CRC64;
MEPPGRRRGR AQPPLLLPLS LLALLALLGG GGGGGAAALP AGCKHDGRPR GAGRAAGAAE
GKVVCSSLEL AQVLPPDTLP NRTVTLILSN NKISELKNGS FSGLSLLERL DLRNNLISSI
DPGAFWGLSS LKRLDLTNNR IGCLNADIFR GLTNLVRLNL SGNLFSSLSQ GTFDYLASLR
SLEFQTEYLL CDCNILWMHR WVKEKNITVR DTRCVYPKSL QAQPVTGVKQ ELLTCDPPLE
LPSFYMTPSH RQVVFEGDSL PFQCMASYID QDMQVLWYQD GRIVETDESQ GIFVEKNMIH
NCSLIASALT ISNIQAGSTG NWGCHVQTKR GNNTRTVDIV VLESSAQYCP PERVVNNKGD
FRWPRTLAGI TAYLQCTRNT HGSGIYPGNP QDERKAWRRC DRGGFWADDD YSRCQYANDV
TRVLYMFNQM PLNLTNAVAT ARQLLAYTVE AANFSDKMDV IFVAEMIEKF GRFTKEEKSK
ELGDVMVDIA SNIMLADERV LWLAQREAKA CSRIVQCLQR IATYRLAGGA HVYSTYSPNI
ALEAYVIKST GFTGMTCTVF QKVAASDRTG LSDYGRRDPE GNLDKQLSFK CNVSNTFSSL
ALKNTIVEAS IQLPPSLFSP KQKRELRPTD DSLYKLQLIA FRNGKLFPAT GNSTNLADDG
KRRTVVTPVI LTKIDGVNVD THHIPVNVTL RRIAHGADAV AARWDFDLLN GQGGWKSDGC
HILYSDENIT TIQCYSLSNY AVLMDLTGSE LYTQAASLLH PVVYTTAIIL LLCLLAVIVS
YIYHHSLIRI SLKSWHMLVN LCFHIFLTCV VFVGGITQTR NASICQAVGI ILHYSTLATV
LWVGVTARNI YKQVTKKAKR CQDPDEPPPP PRPMLRFYLI GGGIPIIVCG ITAAANIKNY
GSRPNAPYCW MAWEPSLGAF YGPASFITFV NCMYFLSIFI QLKRHPERKY ELKEPTEEQQ
RLAANENGEI NHQDSMSLSL ISTSALENEH TFHSQLLGAS LTLLLYVALW MFGALAVSLY
YPLDLVFSFV FGATSLSFSA FFVVHHCVNR EDVRLAWIMT CCPGRSSYSV QVNVQPPNSN
GTNGEAPKCP NSSAESSCTN KSASSFKNSS QGCKLTNLQA AAAQCHANSL PLNSTPQLDN
SLTEHSMDND IKMHVAPLEV QFRTNVHSSR HHKNRSKGHR ASRLTVLREY AYDVPTSVEG
SVQNGLPKSR LGNNEGHSRS RRAYLAYRER QYNPPQQDSS DACSTLPKSS RNFEKPVSTT
SKKDALRKPA VVELENQQKS YGLNLAIQNG PIKSNGQEGP LLGTDSTGNV RTGLWKHETT
V
