ID   ERIC2_HUMAN             Reviewed;         156 AA.
AC   A1L162; A7E2T7;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Glutamate-rich protein 2;
GN   Name=ERICH2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       A1L162; P42858: HTT; NbExp=3; IntAct=EBI-2682520, EBI-466029;
CC       A1L162; Q7L2V5: IWS1; NbExp=3; IntAct=EBI-2682520, EBI-10256178;
CC       A1L162; O75367: MACROH2A1; NbExp=6; IntAct=EBI-2682520, EBI-2868511;
CC       A1L162; Q9UIG4: PSORS1C2; NbExp=3; IntAct=EBI-2682520, EBI-11974061;
CC       A1L162; O00560: SDCBP; NbExp=3; IntAct=EBI-2682520, EBI-727004;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI50547.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CH471058; EAX11231.1; -; Genomic_DNA.
DR   EMBL; BC127676; AAI27677.1; -; mRNA.
DR   EMBL; BC150546; AAI50547.1; ALT_INIT; mRNA.
DR   CCDS; CCDS77486.1; -.
DR   RefSeq; NP_001276876.1; NM_001289947.1.
DR   AlphaFoldDB; A1L162; -.
DR   SMR; A1L162; -.
DR   BioGRID; 130024; 10.
DR   IntAct; A1L162; 6.
DR   STRING; 9606.ENSP00000387298; -.
DR   PhosphoSitePlus; A1L162; -.
DR   BioMuta; ERICH2; -.
DR   jPOST; A1L162; -.
DR   MassIVE; A1L162; -.
DR   PaxDb; A1L162; -.
DR   PeptideAtlas; A1L162; -.
DR   PRIDE; A1L162; -.
DR   Antibodypedia; 57714; 10 antibodies from 6 providers.
DR   DNASU; 285141; -.
DR   Ensembl; ENST00000409885.1; ENSP00000387298.1; ENSG00000204334.7.
DR   GeneID; 285141; -.
DR   KEGG; hsa:285141; -.
DR   UCSC; uc002ugg.4; human.
DR   CTD; 285141; -.
DR   GeneCards; ERICH2; -.
DR   HGNC; HGNC:44395; ERICH2.
DR   HPA; ENSG00000204334; Tissue enriched (testis).
DR   neXtProt; NX_A1L162; -.
DR   OpenTargets; ENSG00000204334; -.
DR   VEuPathDB; HostDB:ENSG00000204334; -.
DR   eggNOG; ENOG502S4MD; Eukaryota.
DR   GeneTree; ENSGT00390000017846; -.
DR   HOGENOM; CLU_083912_0_0_1; -.
DR   InParanoid; A1L162; -.
DR   OMA; NRHKPCP; -.
DR   OrthoDB; 890308at2759; -.
DR   PhylomeDB; A1L162; -.
DR   PathwayCommons; A1L162; -.
DR   SignaLink; A1L162; -.
DR   BioGRID-ORCS; 285141; 3 hits in 221 CRISPR screens.
DR   ChiTaRS; ERICH2; human.
DR   GenomeRNAi; 285141; -.
DR   Pharos; A1L162; Tdark.
DR   PRO; PR:A1L162; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; A1L162; protein.
DR   Bgee; ENSG00000204334; Expressed in left testis and 92 other tissues.
DR   InterPro; IPR026703; ERICH2.
DR   PANTHER; PTHR21520; PTHR21520; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..156
FT                   /note="Glutamate-rich protein 2"
FT                   /id="PRO_0000346762"
FT   REGION          29..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          116..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..54
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..134
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..156
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   156 AA;  17672 MW;  56A1F941C504DC1D CRC64;
     METVNEPETG EVSKDAVIVK QEKNNEYCLQ DIDDKLSESA EDDGEDDTND EDDDEDSNPK
     KNTQAPLELM AEFLRAEMAR EYQLAKKLCQ MILIYEPENP EAKEFFTLIE EMLLMEKTQN
     HEQDGENSDE DSSGESKGES DEELSDESSD EGEDGS