ERIC3_HUMAN
ID ERIC3_HUMAN Reviewed; 1530 AA.
AC Q5RHP9; Q68DL8; Q6GMR8; Q6ZSF9; Q8ND41;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Glutamate-rich protein 3;
GN Name=ERICH3; Synonyms=C1orf173;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 905-1530 (ISOFORMS 1/2), AND VARIANT MET-1528.
RC TISSUE=Brain, and Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1176 (ISOFORM 1), AND VARIANT
RP ALA-264.
RC TISSUE=Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- INTERACTION:
CC Q5RHP9-3; Q92876: KLK6; NbExp=3; IntAct=EBI-20839496, EBI-2432309;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q5RHP9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5RHP9-2; Sequence=VSP_028159;
CC Name=3;
CC IsoId=Q5RHP9-3; Sequence=VSP_028160, VSP_028161, VSP_028162,
CC VSP_028163;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC86994.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; AL834414; CAD39076.1; -; mRNA.
DR EMBL; CR749349; CAH18202.1; -; mRNA.
DR EMBL; AC096950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX470253; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC073916; AAH73916.1; -; mRNA.
DR EMBL; AK127470; BAC86994.1; ALT_SEQ; mRNA.
DR CCDS; CCDS30755.1; -. [Q5RHP9-1]
DR RefSeq; NP_001002912.4; NM_001002912.4. [Q5RHP9-1]
DR RefSeq; XP_016855763.1; XM_017000274.1. [Q5RHP9-1]
DR RefSeq; XP_016855767.1; XM_017000278.1. [Q5RHP9-2]
DR RefSeq; XP_016855768.1; XM_017000279.1. [Q5RHP9-2]
DR RefSeq; XP_016855769.1; XM_017000280.1. [Q5RHP9-2]
DR RefSeq; XP_016855770.1; XM_017000281.1. [Q5RHP9-2]
DR RefSeq; XP_016855771.1; XM_017000282.1. [Q5RHP9-2]
DR RefSeq; XP_016855772.1; XM_017000283.1. [Q5RHP9-2]
DR RefSeq; XP_016855773.1; XM_017000284.1. [Q5RHP9-2]
DR RefSeq; XP_016855774.1; XM_017000285.1. [Q5RHP9-2]
DR AlphaFoldDB; Q5RHP9; -.
DR BioGRID; 126046; 6.
DR IntAct; Q5RHP9; 10.
DR STRING; 9606.ENSP00000322609; -.
DR iPTMnet; Q5RHP9; -.
DR PhosphoSitePlus; Q5RHP9; -.
DR BioMuta; ERICH3; -.
DR DMDM; 74743374; -.
DR jPOST; Q5RHP9; -.
DR MassIVE; Q5RHP9; -.
DR PaxDb; Q5RHP9; -.
DR PeptideAtlas; Q5RHP9; -.
DR PRIDE; Q5RHP9; -.
DR ProteomicsDB; 63735; -. [Q5RHP9-1]
DR ProteomicsDB; 63736; -. [Q5RHP9-2]
DR ProteomicsDB; 63737; -. [Q5RHP9-3]
DR Antibodypedia; 49494; 50 antibodies from 8 providers.
DR Ensembl; ENST00000326665.10; ENSP00000322609.5; ENSG00000178965.14. [Q5RHP9-1]
DR Ensembl; ENST00000420661.6; ENSP00000398581.2; ENSG00000178965.14. [Q5RHP9-3]
DR GeneID; 127254; -.
DR KEGG; hsa:127254; -.
DR MANE-Select; ENST00000326665.10; ENSP00000322609.5; NM_001002912.5; NP_001002912.4.
DR UCSC; uc001dgg.3; human. [Q5RHP9-1]
DR CTD; 127254; -.
DR DisGeNET; 127254; -.
DR GeneCards; ERICH3; -.
DR HGNC; HGNC:25346; ERICH3.
DR HPA; ENSG00000178965; Tissue enhanced (fallopian tube, testis).
DR neXtProt; NX_Q5RHP9; -.
DR OpenTargets; ENSG00000178965; -.
DR PharmGKB; PA142672422; -.
DR VEuPathDB; HostDB:ENSG00000178965; -.
DR eggNOG; ENOG502QVG1; Eukaryota.
DR GeneTree; ENSGT00530000064485; -.
DR HOGENOM; CLU_004102_0_0_1; -.
DR InParanoid; Q5RHP9; -.
DR OMA; EAPQHRD; -.
DR OrthoDB; 213114at2759; -.
DR PhylomeDB; Q5RHP9; -.
DR TreeFam; TF331348; -.
DR PathwayCommons; Q5RHP9; -.
DR SignaLink; Q5RHP9; -.
DR BioGRID-ORCS; 127254; 7 hits in 1041 CRISPR screens.
DR ChiTaRS; ERICH3; human.
DR GenomeRNAi; 127254; -.
DR Pharos; Q5RHP9; Tdark.
DR PRO; PR:Q5RHP9; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5RHP9; protein.
DR Bgee; ENSG00000178965; Expressed in bronchial epithelial cell and 129 other tissues.
DR ExpressionAtlas; Q5RHP9; baseline and differential.
DR Genevisible; Q5RHP9; HS.
DR InterPro; IPR027962; ERICH3.
DR PANTHER; PTHR23034; PTHR23034; 1.
DR Pfam; PF15257; DUF4590; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..1530
FT /note="Glutamate-rich protein 3"
FT /id="PRO_0000304972"
FT REGION 165..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 673..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 773..870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..1146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1167..1334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1360..1383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1425..1530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..564
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..660
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..722
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..790
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 820..835
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 958..991
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1020..1120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1169..1215
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1289..1304
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1305..1324
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1369..1383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1447..1462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1468..1487
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1516..1530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..742
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_028159"
FT VAR_SEQ 1..197
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028160"
FT VAR_SEQ 198..201
FT /note="FPIG -> MLAK (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028161"
FT VAR_SEQ 728..730
FT /note="DSL -> YGR (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028162"
FT VAR_SEQ 731..1530
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028163"
FT VARIANT 264
FT /note="P -> A (in dbSNP:rs11210490)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_035131"
FT VARIANT 555
FT /note="R -> H (in dbSNP:rs696698)"
FT /id="VAR_035132"
FT VARIANT 636
FT /note="I -> V (in dbSNP:rs17095653)"
FT /id="VAR_035133"
FT VARIANT 691
FT /note="H -> R (in dbSNP:rs2305549)"
FT /id="VAR_035134"
FT VARIANT 1056
FT /note="L -> V (in dbSNP:rs11580409)"
FT /id="VAR_035135"
FT VARIANT 1528
FT /note="V -> M (in dbSNP:rs9326116)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_035136"
FT CONFLICT 1101
FT /note="E -> G (in Ref. 4; BAC86994)"
FT /evidence="ECO:0000305"
FT CONFLICT 1177
FT /note="Missing (in Ref. 1; CAD39076)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1530 AA; 168466 MW; 0FC967F01BB92585 CRC64;
MSHSHPAGLL AAYNSLMDKH LAGYFNNTRI RRHLLRSGLI TRSGRILSEK EYKLNMMKRD
HQKYIRECLA QAIFHKVLDM ERYHQLEIKK KLETLARKER IQRFKGEHTR RSVENNMPIL
SPHPPVGPKS NRGHSVLVDE GHSSPLALTA PRPYTAPGNM QPPIRLQPLP SNPAVETVPK
VTSRSRSKTS LLENEALFPI GGKKAVMKFR NSIGNSQRMN SYQLPNINSY MMPIPPPLPP
TGKITRENRS ETWRRRRFRP TTAPNGLEPL LTKDSRRIHK TSLHSNAAIT MIYLGKNVHL
SSDNPDFRDE IKVYQQHCGG ENLCVYKGKL LEKETFQFIS KRHHGFPFSL TFFLNGMQVN
RLSSCCEYKH RKGSRLGGKR GYFGFVCVER SSPCYKCIIA MGLDKKPSLP KSRKEKSTEK
GEELKKAEGK VRKEREYVIP KRNEIKENKT SVSAKFSAQE IKTGLKEVVT AVEEMTSKGK
PGQEVLEDDQ ENTLKYEYEE DFEVDEEKQG EKSNEEGQAD VQMNGIPQSP LDDKKDNLDP
EKESETSSQK APDARDNVKD ENDGCSESEL EEDKQDMKTA SSTSSRSHPY SSDSEDESAV
GDREAHTDSS TDESARRSSS QELSENDKPR KSHLPIEESL EIEIEDQEIT KADVETKPMP
IDESFENVLK EGTEKGTQEI AEGLSEKSGK HVSAEEKEKD KSKLWEESTA QVKDKKAGLP
GLEEGGKDSL PLAYVLALGA PTMNFMVDET AAINSNKESQ QLVQKTYTLE KKEAMEEDEA
PQHRDADIVQ GKGEAALWGE AGAVHEAPLR AWKPTAEQPE LAEEFTEKRE IPPGIERGAE
GAAEAEGVRR LGEGGSDPIG QAAAKDAVGL SKDEAPEKQA LMLTVLETDK AASEGEQGLE
KAVLANEAAA LNLEHLHEVA ALREAATSEE GEAEGGVAVS DVGESEEEAS IDLEDTGPME
DTASKREDGS EEAILGGEEP AKERKEVMRT ETRLSPFTGE AEASRMQVSE GSPEEGSLAK
EAFLCKEDVE GEEMVTEAEA NREDDRKEIL PKELDLARER RKAERPKTSL RKTDSEREEV
TRANALKDED AFKEEQKLKA EEGETETEVR AEEETKAPPN EMGSDAENEA PVEASELSDN
PGLLGEDSLK ETVVPIFEAT PGFEKSLENI TALRKEGGGE RLSEARDTEH KDREELSSRE
NRALKEGHRQ DGEGALAAPE AEPAGKVQAP EGLIPATGQA EELAAKDHDS CAGLEGRAEG
QGGVDVVLRT QEAVAEEDPI MAEKFREEAV DEDPEEEEDK ECTLETEAMQ DRNSEGDGDM
EGEGNTQKNE GMGGGRVVAV EVLHGGGETA ETAAEEREVL AGSETAEEKT IANKASSFSD
VAEEETWHQQ DELVGKTAAA GKVVVEELAR SGEEVPAAEE MTVTYTTEAG VGTPGALERK
TSGLGQEQEE GSEGQEAATG SGDGRQETGA AEKFRLGLSR EGERELSPES LQAMATLPVK
PDFTETREKQ QHMVQGESET ADVSPNNVQV
