ID   ERIC4_HUMAN             Reviewed;         130 AA.
AC   A6NGS2;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Glutamate-rich protein 4;
GN   Name=ERICH4; Synonyms=C19orf69;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
CC   -!- INTERACTION:
CC       A6NGS2; Q15172: PPP2R5A; NbExp=3; IntAct=EBI-18398448, EBI-641666;
CC       A6NGS2; P51687: SUOX; NbExp=3; IntAct=EBI-18398448, EBI-3921347;
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DR   EMBL; AC011526; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS46085.1; -.
DR   RefSeq; NP_001123986.1; NM_001130514.1.
DR   AlphaFoldDB; A6NGS2; -.
DR   SMR; A6NGS2; -.
DR   BioGRID; 936859; 2.
DR   IntAct; A6NGS2; 2.
DR   BioMuta; ERICH4; -.
DR   MassIVE; A6NGS2; -.
DR   PaxDb; A6NGS2; -.
DR   PeptideAtlas; A6NGS2; -.
DR   PRIDE; A6NGS2; -.
DR   ProteomicsDB; 1148; -.
DR   Antibodypedia; 65006; 9 antibodies from 5 providers.
DR   DNASU; 100170765; -.
DR   Ensembl; ENST00000378187.3; ENSP00000367429.2; ENSG00000204978.3.
DR   GeneID; 100170765; -.
DR   KEGG; hsa:100170765; -.
DR   MANE-Select; ENST00000378187.3; ENSP00000367429.2; NM_001130514.3; NP_001123986.1.
DR   UCSC; uc010xwc.2; human.
DR   CTD; 100170765; -.
DR   GeneCards; ERICH4; -.
DR   HGNC; HGNC:34497; ERICH4.
DR   HPA; ENSG00000204978; Group enriched (intestine, kidney).
DR   neXtProt; NX_A6NGS2; -.
DR   OpenTargets; ENSG00000204978; -.
DR   PharmGKB; PA162378862; -.
DR   VEuPathDB; HostDB:ENSG00000204978; -.
DR   eggNOG; ENOG502RWFY; Eukaryota.
DR   GeneTree; ENSGT00390000006319; -.
DR   HOGENOM; CLU_152287_0_0_1; -.
DR   InParanoid; A6NGS2; -.
DR   OMA; LWRQLNQ; -.
DR   OrthoDB; 1602431at2759; -.
DR   PhylomeDB; A6NGS2; -.
DR   TreeFam; TF352665; -.
DR   PathwayCommons; A6NGS2; -.
DR   SignaLink; A6NGS2; -.
DR   BioGRID-ORCS; 100170765; 5 hits in 203 CRISPR screens.
DR   GenomeRNAi; 100170765; -.
DR   Pharos; A6NGS2; Tdark.
DR   PRO; PR:A6NGS2; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; A6NGS2; protein.
DR   Bgee; ENSG00000204978; Expressed in jejunal mucosa and 94 other tissues.
DR   Genevisible; A6NGS2; HS.
DR   InterPro; IPR029202; DUF4530.
DR   PANTHER; PTHR36879; PTHR36879; 1.
DR   Pfam; PF15039; DUF4530; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..130
FT                   /note="Glutamate-rich protein 4"
FT                   /id="PRO_0000340277"
FT   REGION          91..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        102..120
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   130 AA;  14477 MW;  5DC372C000DB8040 CRC64;
     MELWRQLNQA GLVPPGLGPP PQALREVSPV EIPGQTLRTA GADTGGACDS LLWIREELGN
     LRRVDVQLLG QLCSLGLEMG ALREELVTIL EEEEESSKEE EEDQEPQRKQ EEEHLEACPA
     PHPPDFEMMI