ERIC5_HUMAN
ID ERIC5_HUMAN Reviewed; 374 AA.
AC Q6P6B1; G3V1K4; Q8N1L8;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Glutamate-rich protein 5;
GN Name=ERICH5; Synonyms=C8orf47;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Rectum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6P6B1; Q14145: KEAP1; NbExp=3; IntAct=EBI-11343491, EBI-751001;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6P6B1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6P6B1-2; Sequence=VSP_046650;
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DR EMBL; AK096872; BAC04880.1; -; mRNA.
DR EMBL; AP003352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP003439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471060; EAW91772.1; -; Genomic_DNA.
DR EMBL; BC062359; AAH62359.1; -; mRNA.
DR CCDS; CCDS34929.1; -. [Q6P6B1-1]
DR CCDS; CCDS55266.1; -. [Q6P6B1-2]
DR RefSeq; NP_001164277.1; NM_001170806.1. [Q6P6B1-2]
DR RefSeq; NP_775820.2; NM_173549.2. [Q6P6B1-1]
DR AlphaFoldDB; Q6P6B1; -.
DR BioGRID; 128453; 60.
DR IntAct; Q6P6B1; 22.
DR STRING; 9606.ENSP00000315614; -.
DR iPTMnet; Q6P6B1; -.
DR PhosphoSitePlus; Q6P6B1; -.
DR BioMuta; ERICH5; -.
DR DMDM; 74737479; -.
DR EPD; Q6P6B1; -.
DR MassIVE; Q6P6B1; -.
DR MaxQB; Q6P6B1; -.
DR PaxDb; Q6P6B1; -.
DR PeptideAtlas; Q6P6B1; -.
DR PRIDE; Q6P6B1; -.
DR ProteomicsDB; 32360; -.
DR ProteomicsDB; 67018; -. [Q6P6B1-1]
DR Antibodypedia; 13018; 62 antibodies from 9 providers.
DR DNASU; 203111; -.
DR Ensembl; ENST00000318528.8; ENSP00000315614.3; ENSG00000177459.11. [Q6P6B1-1]
DR Ensembl; ENST00000545282.1; ENSP00000440297.1; ENSG00000177459.11. [Q6P6B1-2]
DR GeneID; 203111; -.
DR KEGG; hsa:203111; -.
DR MANE-Select; ENST00000318528.8; ENSP00000315614.3; NM_173549.3; NP_775820.2.
DR UCSC; uc003yih.2; human. [Q6P6B1-1]
DR CTD; 203111; -.
DR GeneCards; ERICH5; -.
DR HGNC; HGNC:26823; ERICH5.
DR HPA; ENSG00000177459; Tissue enhanced (pancreas).
DR neXtProt; NX_Q6P6B1; -.
DR OpenTargets; ENSG00000177459; -.
DR PharmGKB; PA142672366; -.
DR VEuPathDB; HostDB:ENSG00000177459; -.
DR eggNOG; ENOG502SVIU; Eukaryota.
DR GeneTree; ENSGT00390000010783; -.
DR HOGENOM; CLU_064315_0_0_1; -.
DR InParanoid; Q6P6B1; -.
DR OMA; MNDPLHK; -.
DR OrthoDB; 962254at2759; -.
DR PhylomeDB; Q6P6B1; -.
DR TreeFam; TF337219; -.
DR PathwayCommons; Q6P6B1; -.
DR SignaLink; Q6P6B1; -.
DR BioGRID-ORCS; 203111; 16 hits in 1063 CRISPR screens.
DR GenomeRNAi; 203111; -.
DR Pharos; Q6P6B1; Tdark.
DR PRO; PR:Q6P6B1; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q6P6B1; protein.
DR Bgee; ENSG00000177459; Expressed in palpebral conjunctiva and 119 other tissues.
DR Genevisible; Q6P6B1; HS.
DR InterPro; IPR027856; DUF4573.
DR Pfam; PF15140; DUF4573; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..374
FT /note="Glutamate-rich protein 5"
FT /id="PRO_0000294433"
FT REGION 1..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..367
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 169
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8K0S2"
FT VAR_SEQ 20..337
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_046650"
FT VARIANT 59
FT /note="R -> H (in dbSNP:rs7833473)"
FT /id="VAR_033176"
FT VARIANT 244
FT /note="Q -> P (in dbSNP:rs35368005)"
FT /id="VAR_033177"
FT VARIANT 287
FT /note="H -> R (in dbSNP:rs11994440)"
FT /id="VAR_033178"
FT CONFLICT 326
FT /note="N -> S (in Ref. 1; BAC04880)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 374 AA; 39936 MW; 78FEE6D3CEF9011A CRC64;
MGCSSSALNK AGDSSRFPSV TSNEHFSTAE ESESCFAQPK PHALGRESTV DGNVQRESRP
PLQKLKVSAE PTANGVKPLQ EQPLAKDVAP GRDATDQSGS TEKTQPGEGL EESGPPQPGG
KEDAPAAEGK KKDAGAGTEA ESLKGNAEAQ PLGPEAKGQP LQAAVEKDSL RAVEVTENPQ
TAAEMKPLGT TENVLTLQIA GELQPQGTVG KDEQAPLLET ISKENESPEI LEGSQFVETA
EEQQLQATLG KEEQPQLLER IPKENVTPEV LDRSQLVEKP VMNDPFHKTP EGPGNMEQIQ
PEGIVGSMEH PARNVEAGAY VEMIRNIHTN EEDQRIEGET GEKVETDMEN EKVSEGAETK
EEETGEVVDL SAAT
