ID   ERIC_PSESM              Reviewed;         452 AA.
AC   Q87WD2;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Chloride/fluoride channel protein;
GN   Name=eriC; OrderedLocusNames=PSPTO_4619;
OS   Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=223283;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-871 / DC3000;
RX   PubMed=12928499; DOI=10.1073/pnas.1731982100;
RA   Buell C.R., Joardar V., Lindeberg M., Selengut J., Paulsen I.T.,
RA   Gwinn M.L., Dodson R.J., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA   Daugherty S.C., Brinkac L.M., Beanan M.J., Haft D.H., Nelson W.C.,
RA   Davidsen T.M., Zafar N., Zhou L., Liu J., Yuan Q., Khouri H.M.,
RA   Fedorova N.B., Tran B., Russell D., Berry K.J., Utterback T.R.,
RA   Van Aken S.E., Feldblyum T.V., D'Ascenzo M., Deng W.-L., Ramos A.R.,
RA   Alfano J.R., Cartinhour S., Chatterjee A.K., Delaney T.P., Lazarowitz S.G.,
RA   Martin G.B., Schneider D.J., Tang X., Bender C.L., White O., Fraser C.M.,
RA   Collmer A.;
RT   "The complete genome sequence of the Arabidopsis and tomato pathogen
RT   Pseudomonas syringae pv. tomato DC3000.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:10181-10186(2003).
RN   [2]
RP   FUNCTION IN TRANSPORT, INDUCTION, AND GENE NAME.
RC   STRAIN=ATCC BAA-871 / DC3000;
RX   PubMed=22194412; DOI=10.1126/science.1215063;
RA   Baker J.L., Sudarsan N., Weinberg Z., Roth A., Stockbridge R.B.,
RA   Breaker R.R.;
RT   "Widespread genetic switches and toxicity resistance proteins for
RT   fluoride.";
RL   Science 335:233-235(2012).
CC   -!- FUNCTION: Transports chloride and fluoride with similar efficiency.
CC       {ECO:0000269|PubMed:22194412}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: By fluoride, via a fluoride-responsive riboswitch.
CC       {ECO:0000269|PubMed:22194412}.
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC       {ECO:0000305}.
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DR   EMBL; AE016853; AAO58065.1; -; Genomic_DNA.
DR   RefSeq; NP_794370.1; NC_004578.1.
DR   AlphaFoldDB; Q87WD2; -.
DR   SMR; Q87WD2; -.
DR   STRING; 223283.PSPTO_4619; -.
DR   TCDB; 2.A.49.9.5; the chloride carrier/channel (clc) family.
DR   EnsemblBacteria; AAO58065; AAO58065; PSPTO_4619.
DR   KEGG; pst:PSPTO_4619; -.
DR   PATRIC; fig|223283.9.peg.4732; -.
DR   eggNOG; COG0038; Bacteria.
DR   HOGENOM; CLU_015263_1_1_6; -.
DR   OMA; NPYYRVL; -.
DR   OrthoDB; 1560952at2; -.
DR   PhylomeDB; Q87WD2; -.
DR   Proteomes; UP000002515; Chromosome.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   SUPFAM; SSF81340; SSF81340; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Chloride; Chloride channel; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..452
FT                   /note="Chloride/fluoride channel protein"
FT                   /id="PRO_0000428836"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        386..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   452 AA;  48306 MW;  F9583A01AEFC8E9C CRC64;
     MAGQMSKFRR PEQLDLLPYI AKWLALAGLV ALLAGSASAL FLLSLDHATQ WRETHPWVIW
     LLPVAGFAVG LAYHLIGKPV DAGNNLIIDE IHDPKKIVPL RMVPMVLIGT VVSHLFGASV
     GREGTAVQMG GALADQLTHV FRLRREDRRV ILMAGISAGF ASVFGTPLAG ALFGLEVLAI
     GRMRYDALFP CVVAAIVADQ VGQAWGVVHT HYVIGEVVPV QLWSVMAVVA AGIVFGLTGL
     LFATATHKLG AFVKRLITYS PLRPFAGGLL IAVAVWALGS NHYIDVDKYI GLGIPSIVQS
     FQMPMAPWDW LGKMVFTVVS LGTGFKGGEV TPLFYIGATL GNALAPLLHL PFGMLAGIGF
     VAVFAGAANT PLATIVMAME LFGPEIAPLA AIACIASYLV SGHTGIYHAQ RVGHSKHHRP
     LPEEIRLSDI KQFHAQSESA SERKVTLAGE EK