ID   AGRA_STAAC              Reviewed;         238 AA.
AC   Q5HEG2;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Accessory gene regulator A;
GN   Name=agrA; OrderedLocusNames=SACOL2026;
OS   Staphylococcus aureus (strain COL).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Required for high-level post-exponential phase expression of
CC       a series of secreted proteins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000046; AAW36991.1; -; Genomic_DNA.
DR   RefSeq; WP_000688492.1; NC_002951.2.
DR   PDB; 4XQJ; X-ray; 1.90 A; A/D=140-238.
DR   PDB; 4XQN; X-ray; 2.30 A; A/D/G/J=140-238.
DR   PDB; 4XQQ; X-ray; 3.05 A; A/B/C/D=139-238.
DR   PDB; 4XXE; X-ray; 3.20 A; A/D=140-238.
DR   PDB; 4XYO; X-ray; 2.00 A; A=140-238.
DR   PDB; 4XYQ; X-ray; 2.40 A; A=137-238.
DR   PDBsum; 4XQJ; -.
DR   PDBsum; 4XQN; -.
DR   PDBsum; 4XQQ; -.
DR   PDBsum; 4XXE; -.
DR   PDBsum; 4XYO; -.
DR   PDBsum; 4XYQ; -.
DR   AlphaFoldDB; Q5HEG2; -.
DR   BMRB; Q5HEG2; -.
DR   SMR; Q5HEG2; -.
DR   EnsemblBacteria; AAW36991; AAW36991; SACOL2026.
DR   KEGG; sac:SACOL2026; -.
DR   HOGENOM; CLU_000445_14_6_9; -.
DR   OMA; ISVYICE; -.
DR   PRO; PR:Q5HEG2; -.
DR   Proteomes; UP000000530; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR007492; LytTR_DNA-bd_dom.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF04397; LytTR; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00850; LytTR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50930; HTH_LYTTR; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Activator; Cytoplasm; DNA-binding; Phosphoprotein;
KW   Transcription; Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..238
FT                   /note="Accessory gene regulator A"
FT                   /id="PRO_0000080995"
FT   DOMAIN          2..125
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          143..238
FT                   /note="HTH LytTR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00112"
FT   MOD_RES         59
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   STRAND          142..146
FT                   /evidence="ECO:0007829|PDB:4XQJ"
FT   STRAND          151..155
FT                   /evidence="ECO:0007829|PDB:4XQJ"
FT   HELIX           156..158
FT                   /evidence="ECO:0007829|PDB:4XQJ"
FT   STRAND          160..164
FT                   /evidence="ECO:0007829|PDB:4XQJ"
FT   STRAND          170..174
FT                   /evidence="ECO:0007829|PDB:4XQJ"
FT   STRAND          179..183
FT                   /evidence="ECO:0007829|PDB:4XQJ"
FT   HELIX           186..192
FT                   /evidence="ECO:0007829|PDB:4XQJ"
FT   STRAND          196..200
FT                   /evidence="ECO:0007829|PDB:4XQJ"
FT   STRAND          203..206
FT                   /evidence="ECO:0007829|PDB:4XQJ"
FT   HELIX           207..209
FT                   /evidence="ECO:0007829|PDB:4XQJ"
FT   STRAND          210..214
FT                   /evidence="ECO:0007829|PDB:4XQJ"
FT   TURN            215..218
FT                   /evidence="ECO:0007829|PDB:4XQJ"
FT   STRAND          219..222
FT                   /evidence="ECO:0007829|PDB:4XQJ"
FT   STRAND          227..229
FT                   /evidence="ECO:0007829|PDB:4XQJ"
FT   TURN            232..234
FT                   /evidence="ECO:0007829|PDB:4XQJ"
FT   HELIX           235..237
FT                   /evidence="ECO:0007829|PDB:4XQJ"
SQ   SEQUENCE   238 AA;  27906 MW;  757788C90AAFB420 CRC64;
     MKIFICEDDP KQRENMVTII KNYIMIEEKP MEIALATDNP YEVLEQAKNM NDIGCYFLDI
     QLSTDINGIK LGSEIRKHDP VGNIIFVTSH SELTYLTFVY KVAAMDFIFK DDPAELRTRI
     IDCLETAHTR LQLLSKDNSV ETIELKRGSN SVYVQYDDIM FFESSTKSHR LIAHLDNRQI
     EFYGNLKELS QLDDRFFRCH NSFVVNRHNI ESIDSKERIV YFKNKEHCYA SVRNVKKI