ERJ5_YEAST
ID ERJ5_YEAST Reviewed; 295 AA.
AC P43613; D6VTS4;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=ER-localized J domain-containing protein 5;
DE Flags: Precursor;
GN Name=ERJ5; OrderedLocusNames=YFR041C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204511 / S288c / AB972;
RX PubMed=8686379;
RX DOI=10.1002/(sici)1097-0061(199602)12:2<149::aid-yea893>3.0.co;2-g;
RA Eki T., Naitou M., Hagiwara H., Ozawa M., Sasanuma S., Sasanuma M.,
RA Tsuchiya Y., Shibata T., Hanaoka F., Murakami Y.;
RT "Analysis of a 36.2 kb DNA sequence including the right telomere of
RT chromosome VI from Saccharomyces cerevisiae.";
RL Yeast 12:149-167(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7670463; DOI=10.1038/ng0795-261;
RA Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S.,
RA Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H.,
RA Eki T.;
RT "Analysis of the nucleotide sequence of chromosome VI from Saccharomyces
RT cerevisiae.";
RL Nat. Genet. 10:261-268(1995).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
RN [6]
RP SUBCELLULAR LOCATION, SIGNAL SEQUENCE CLEAVAGE, TOPOLOGY, AND FUNCTION.
RX PubMed=17157937; DOI=10.1016/j.bbamcr.2006.10.011;
RA Carla Fama M., Raden D., Zacchi N., Lemos D.R., Robinson A.S.,
RA Silberstein S.;
RT "The Saccharomyces cerevisiae YFR041C/ERJ5 gene encoding a type I membrane
RT protein with a J domain is required to preserve the folding capacity of the
RT endoplasmic reticulum.";
RL Biochim. Biophys. Acta 1773:232-242(2007).
CC -!- FUNCTION: DnaJ-like chaperone required for the folding capacity of the
CC endoplasmic reticulum. {ECO:0000269|PubMed:17157937}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:17157937}; Single-pass
CC type I membrane protein {ECO:0000269|PubMed:14562095,
CC ECO:0000269|PubMed:17157937}.
CC -!- SIMILARITY: Belongs to the DnaJ family. {ECO:0000305}.
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DR EMBL; D50617; BAA09280.1; -; Genomic_DNA.
DR EMBL; BK006940; DAA12484.1; -; Genomic_DNA.
DR PIR; S56296; S56296.
DR RefSeq; NP_116699.3; NM_001180006.3.
DR AlphaFoldDB; P43613; -.
DR SMR; P43613; -.
DR BioGRID; 31199; 42.
DR IntAct; P43613; 2.
DR MINT; P43613; -.
DR STRING; 4932.YFR041C; -.
DR iPTMnet; P43613; -.
DR MaxQB; P43613; -.
DR PaxDb; P43613; -.
DR PRIDE; P43613; -.
DR EnsemblFungi; YFR041C_mRNA; YFR041C; YFR041C.
DR GeneID; 850602; -.
DR KEGG; sce:YFR041C; -.
DR SGD; S000001937; ERJ5.
DR VEuPathDB; FungiDB:YFR041C; -.
DR eggNOG; KOG0724; Eukaryota.
DR HOGENOM; CLU_037236_2_0_1; -.
DR InParanoid; P43613; -.
DR OMA; RKTYDYY; -.
DR BioCyc; YEAST:G3O-30488-MON; -.
DR PRO; PR:P43613; -.
DR Proteomes; UP000002311; Chromosome VI.
DR RNAct; P43613; protein.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:SGD.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006457; P:protein folding; IMP:SGD.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR018253; DnaJ_domain_CS.
DR InterPro; IPR036869; J_dom_sf.
DR Pfam; PF00226; DnaJ; 1.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR PROSITE; PS00636; DNAJ_1; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 1: Evidence at protein level;
KW Chaperone; Endoplasmic reticulum; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT CHAIN 21..295
FT /note="ER-localized J domain-containing protein 5"
FT /id="PRO_0000007272"
FT TOPO_DOM 21..130
FT /note="Lumenal"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..295
FT /note="Cytoplasmic"
FT DOMAIN 42..110
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT REGION 259..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 295 AA; 34191 MW; 4541BF6C353DB8AC CRC64;
MNGYWKPALV VLGLVSLSYA FTTIETEIFQ LQNEISTKYG PDMNFYKFLK LPKLQNSSTK
EITKNLRKLS KKYHPDKNPK YRKLYERLNL ATQILSNSSN RKIYDYYLQN GFPNYDFHKG
GFYFSRMKPK TWFLLAFIWI VVNIGQYIIS IIQYRSQRSR IENFISQCKQ QDDTNGLGVK
QLTFKQHEKD EGKSLVVRFS DVYVVEPDGS ETLISPDTLD KPSVKNCLFW RIPASVWNMT
FGKSVGSAGK EEIITDSKKY DGNQTKKGNK VKKGSAKKGQ KKMELPNGKV IYSRK
