ID   ERL2B_XENLA             Reviewed;         330 AA.
AC   Q6DKC0;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Erlin-2-B;
DE   AltName: Full=Endoplasmic reticulum lipid raft-associated protein 2-B;
DE   AltName: Full=Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2-B;
DE            Short=SPFH domain-containing protein 2-B;
GN   Name=erlin2-b; Synonyms=spfh2-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH74372.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000312|EMBL:AAH74372.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the endoplasmic reticulum-associated degradation
CC       (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Promotes
CC       sterol-accelerated ERAD of HMGCR. Involved in regulation of cellular
CC       cholesterol homeostasis by regulation the SREBP signaling pathway (By
CC       similarity). {ECO:0000250|UniProtKB:O94905}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:O94905, ECO:0000255}; Single-pass type II
CC       membrane protein {ECO:0000250|UniProtKB:O94905, ECO:0000255}.
CC       Note=Associated with lipid raft-like domains of the endoplasmic
CC       reticulum membrane. {ECO:0000250|UniProtKB:O94905, ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the band 7/mec-2 family. {ECO:0000255}.
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DR   EMBL; BC074372; AAH74372.1; -; mRNA.
DR   RefSeq; NP_001086246.1; NM_001092777.1.
DR   AlphaFoldDB; Q6DKC0; -.
DR   SMR; Q6DKC0; -.
DR   DNASU; 444675; -.
DR   GeneID; 444675; -.
DR   KEGG; xla:444675; -.
DR   CTD; 444675; -.
DR   Xenbase; XB-GENE-6254593; erlin2.S.
DR   OMA; YNMVRNF; -.
DR   OrthoDB; 930534at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 444675; Expressed in lung and 19 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd03406; SPFH_like_u3; 1.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR033294; Erlin1/2.
DR   PANTHER; PTHR15351; PTHR15351; 1.
DR   Pfam; PF01145; Band_7; 1.
DR   SMART; SM00244; PHB; 1.
PE   2: Evidence at transcript level;
KW   Cholesterol metabolism; Endoplasmic reticulum; Glycoprotein;
KW   Lipid metabolism; Membrane; Reference proteome; Signal-anchor;
KW   Steroid metabolism; Sterol metabolism; Transmembrane; Transmembrane helix.
FT   CHAIN           1..330
FT                   /note="Erlin-2-B"
FT                   /id="PRO_0000378629"
FT   TOPO_DOM        1..2
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        24..330
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   REGION          308..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        106
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   330 AA;  36846 MW;  765B45071D965129 CRC64;
     MSHAGAIAAL GVALIAAALF SAIHKIEEGH VGVYYRGGAL LTTTSGPGFH LMLPFITSFK
     SVQSTLQTDE VKNVPCGTSG GVMIYFDRIE VVNYLISSAV YDIVKNYTAD YDKALIFNKI
     HHELNQFCSV HNLQEVYIEL FDQIDEDLKL ALQKDLNLMA PGIIIQAVRV TKPNIPEAIR
     RNYELMESEK TKLLIAAQKQ KVVEKEAETE RKKAIIEAEK VAQVAQIKYG QKVMEKETEK
     KISEIEDFAF LAREKARADA EYYTAQKAAE ANKLKLTPEY LQLMKYQAIA ANSKIYFGQD
     IPNMFMDSSS AGPRVQSAKR NEPAAAEELK