ID   ERLN1_XENTR             Reviewed;         319 AA.
AC   Q28DX1;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Erlin-1 {ECO:0000250|UniProtKB:O75477};
DE   AltName: Full=Endoplasmic reticulum lipid raft-associated protein 1 {ECO:0000250|UniProtKB:O75477};
DE   AltName: Full=Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1 {ECO:0000250|UniProtKB:O75477};
DE            Short=SPFH domain-containing protein 1 {ECO:0000250|UniProtKB:O75477};
GN   Name=erlin1; Synonyms=spfh1 {ECO:0000312|EMBL:CAJ81885.1};
GN   ORFNames=TEgg032d13.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:CAJ81885.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg {ECO:0000312|EMBL:CAJ81885.1};
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:CAJ81885.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6 {ECO:0000312|EMBL:AAI21570.1};
RC   TISSUE=Heart {ECO:0000312|EMBL:AAI21570.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the endoplasmic reticulum-associated degradation
CC       (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in
CC       regulation of cellular cholesterol homeostasis by regulation the SREBP
CC       signaling pathway. Binds cholesterol and may promote ER retention of
CC       the SCAP-SREBF complex. {ECO:0000250|UniProtKB:O75477}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:O94905, ECO:0000255}; Single-pass type II
CC       membrane protein {ECO:0000250|UniProtKB:O94905, ECO:0000255}.
CC       Note=Associated with lipid raft-like domains of the endoplasmic
CC       reticulum membrane. {ECO:0000250|UniProtKB:O94905, ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the band 7/mec-2 family. {ECO:0000255}.
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DR   EMBL; CR848555; CAJ81885.1; -; mRNA.
DR   EMBL; BC121569; AAI21570.1; -; mRNA.
DR   RefSeq; NP_001016892.1; NM_001016892.2.
DR   RefSeq; XP_012822096.1; XM_012966642.2.
DR   AlphaFoldDB; Q28DX1; -.
DR   STRING; 8364.ENSXETP00000062578; -.
DR   PaxDb; Q28DX1; -.
DR   Ensembl; ENSXETT00000001887; ENSXETP00000001887; ENSXETG00000000849.
DR   GeneID; 549646; -.
DR   KEGG; xtr:549646; -.
DR   CTD; 10613; -.
DR   Xenbase; XB-GENE-5794201; erlin1.
DR   eggNOG; KOG2962; Eukaryota.
DR   HOGENOM; CLU_058701_0_0_1; -.
DR   InParanoid; Q28DX1; -.
DR   OrthoDB; 930534at2759; -.
DR   PhylomeDB; Q28DX1; -.
DR   Reactome; R-XTR-382556; ABC-family proteins mediated transport.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000000849; Expressed in heart and 13 other tissues.
DR   ExpressionAtlas; Q28DX1; baseline.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015485; F:cholesterol binding; IBA:GO_Central.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0032933; P:SREBP signaling pathway; IBA:GO_Central.
DR   CDD; cd03406; SPFH_like_u3; 1.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR033294; Erlin1/2.
DR   PANTHER; PTHR15351; PTHR15351; 1.
DR   Pfam; PF01145; Band_7; 1.
DR   SMART; SM00244; PHB; 1.
PE   2: Evidence at transcript level;
KW   Cholesterol metabolism; Endoplasmic reticulum; Glycoprotein;
KW   Lipid metabolism; Lipid-binding; Membrane; Reference proteome;
KW   Signal-anchor; Steroid metabolism; Sterol metabolism; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..319
FT                   /note="Erlin-1"
FT                   /id="PRO_0000378626"
FT   TOPO_DOM        1..6
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        7..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        24..319
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        106
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   319 AA;  36311 MW;  FF996C6434C5409B CRC64;
     MAHFGVVVGL MMILVFLVFL SSIHKVEEGH LAVYYRGGAL LGGPGDPGYH IMFPFITYFR
     SVQTTLQTDE VKNVPCGTSG GVMIYFDRIE VVNMLTPSAV YDVVRNYTAD YDKTLIFNKI
     HHELNQFCSS HTLQEVYIEL FDQIDENLKL SLQMELNVMA PGLTIQAVRV TKPKIPEAIR
     RNFELMESEK TKLLIAEQRQ KVVEKEAETE RKKAVIEAEK VAQVAKIQYR QKVMEKETEK
     FISEIEDSAY LAREKAKADA EYYTAQKSAD ANKLKLTPQY LELIKYQAVS ANNKIYFGSN
     IPTMFFDSSS RSRIEGKSA