ID   ERLN2_XENTR             Reviewed;         335 AA.
AC   Q28J34;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Erlin-2 {ECO:0000250|UniProtKB:O94905};
DE   AltName: Full=Endoplasmic reticulum lipid raft-associated protein 2 {ECO:0000250|UniProtKB:O94905};
DE   AltName: Full=Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 {ECO:0000250|UniProtKB:O94905};
DE            Short=SPFH domain-containing protein 2 {ECO:0000250|UniProtKB:O94905};
GN   Name=erlin2; Synonyms=spfh2 {ECO:0000312|EMBL:CAJ82623.1};
GN   ORFNames=TNeu008k01.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:CAJ82623.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula {ECO:0000312|EMBL:CAJ82623.1};
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:CAJ82623.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula {ECO:0000312|EMBL:AAI58954.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the endoplasmic reticulum-associated degradation
CC       (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Promotes
CC       sterol-accelerated ERAD of HMGCR. Involved in regulation of cellular
CC       cholesterol homeostasis by regulation the SREBP signaling pathway (By
CC       similarity). {ECO:0000250|UniProtKB:O94905}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:O94905, ECO:0000255}; Single-pass type II
CC       membrane protein {ECO:0000250|UniProtKB:O94905, ECO:0000255}.
CC       Note=Associated with lipid raft-like domains of the endoplasmic
CC       reticulum membrane. {ECO:0000250|UniProtKB:O94905, ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the band 7/mec-2 family. {ECO:0000255}.
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DR   EMBL; CR760081; CAJ82623.1; -; mRNA.
DR   EMBL; BC158953; AAI58954.1; -; mRNA.
DR   RefSeq; NP_001016719.1; NM_001016719.2.
DR   RefSeq; XP_012814492.1; XM_012959038.2.
DR   RefSeq; XP_017947582.1; XM_018092093.1.
DR   AlphaFoldDB; Q28J34; -.
DR   SMR; Q28J34; -.
DR   PaxDb; Q28J34; -.
DR   GeneID; 549473; -.
DR   KEGG; xtr:549473; -.
DR   CTD; 11160; -.
DR   Xenbase; XB-GENE-950144; erlin2.
DR   eggNOG; KOG2962; Eukaryota.
DR   HOGENOM; CLU_058701_0_0_1; -.
DR   InParanoid; Q28J34; -.
DR   OrthoDB; 930534at2759; -.
DR   PhylomeDB; Q28J34; -.
DR   Reactome; R-XTR-382556; ABC-family proteins mediated transport.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015485; F:cholesterol binding; IBA:GO_Central.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0032933; P:SREBP signaling pathway; IBA:GO_Central.
DR   CDD; cd03406; SPFH_like_u3; 1.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR033294; Erlin1/2.
DR   PANTHER; PTHR15351; PTHR15351; 1.
DR   Pfam; PF01145; Band_7; 1.
DR   SMART; SM00244; PHB; 1.
PE   2: Evidence at transcript level;
KW   Cholesterol metabolism; Endoplasmic reticulum; Glycoprotein;
KW   Lipid metabolism; Membrane; Reference proteome; Signal-anchor;
KW   Steroid metabolism; Sterol metabolism; Transmembrane; Transmembrane helix.
FT   CHAIN           1..335
FT                   /note="Erlin-2"
FT                   /id="PRO_0000378630"
FT   TOPO_DOM        1..2
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        24..335
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   REGION          310..335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        106
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   335 AA;  37148 MW;  30608F07757515D4 CRC64;
     MSHAGAIAAI GVALIAAALF SAIHKIEEGH VGVYYRGGAL LTSTSGPGFH LMLPFITSFK
     SVQSTMQTDE VKNVPCGTSG GVMIYFDRIE VVNYLIPSAV YDIVKNYTAD YDKTLIFNKI
     HHELNQFCSV HNLQEVYIEL FDQIDENLKL ALQKDLNSMA PGLVIQAVRV TKPNIPEAIR
     RNYELMESEK TKLLIAAQKQ KVVEKEAETE RKKAIIEAEK VAQVAEIKYG QKVMEKETEK
     KISEIEDSAF VAREKAKADA EYYTSQKTAD ANRLKLTPEY LQLVKYQAIA ANSKIYFGQD
     IPNMFMDSSA GPSVQSATLL QDDSPALNEP AVGDE