ERMAP_HUMAN
ID ERMAP_HUMAN Reviewed; 475 AA.
AC Q96PL5; D3DPW8; Q5VV53; Q6DUE0; Q7Z3X0; Q8NCV8; Q8NCW2; Q8NCW3; Q96PL6;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Erythroid membrane-associated protein;
DE Short=hERMAP;
DE AltName: Full=Radin blood group antigen;
DE AltName: Full=Scianna blood group antigen;
DE Flags: Precursor;
GN Name=ERMAP; Synonyms=RD, SC;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC TISSUE=Fetal liver;
RX PubMed=11783959; DOI=10.1006/bcmd.2001.0465;
RA Su Y.-Y., Gordon C.T., Ye T.-Z., Perkins A.C., Chui D.H.K.;
RT "Human ERMAP: an erythroid adhesion/receptor transmembrane protein.";
RL Blood Cells Mol. Dis. 27:938-949(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP SUBCELLULAR LOCATION.
RC TISSUE=Fetal liver;
RX PubMed=11549310; DOI=10.1006/geno.2001.6600;
RA Xu H., Foltz L., Sha Y., Madlansacay M.R., Cain C., Lindemann G.,
RA Vargas J., Nagy D., Harriman B., Mahoney W., Schueler P.A.;
RT "Cloning and characterization of human erythroid membrane-associated
RT protein, human ERMAP.";
RL Genomics 76:2-4(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE SC-3), POLYMORPHISM, VARIANTS
RP BLOOD GROUP SC2 ARG-57 AND SC4 ALA-60, AND VARIANT TYR-26.
RX PubMed=12393480; DOI=10.1182/blood-2002-07-2064;
RA Wagner F.F., Poole J., Flegel W.A.;
RT "Scianna antigens including Rd are expressed by ERMAP.";
RL Blood 101:752-757(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS VAL-4; TYR-26; ARG-259 AND
RP GLU-263.
RG SeattleSNPs variation discovery resource;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 30-144, POLYMORPHISM, AND VARIANT
RP BLOOD GROUP SC5 LYS-47.
RX PubMed=15660834; DOI=10.1111/j.1537-2995.2004.04226.x;
RA Hue-Roye K., Chaudhuri A., Velliquette R.W., Fetics S., Thomas R., Balk M.,
RA Wagner F.F., Flegel W.A., Reid M.E.;
RT "STAR: a novel high-prevalence antigen in the Scianna blood group system.";
RL Transfusion 45:245-247(2005).
RN [10]
RP POLYMORPHISM, AND VARIANTS BLOOD GROUP SC7 SER-35 AND SC6 GLN-81.
RX PubMed=16371048; DOI=10.1111/j.1537-2995.2005.00646.x;
RA Flegel W.A., Chen Q., Reid M.E., Martin J., Orsini L.A., Poole J.,
RA Moulds M.K., Wagner F.F.;
RT "SCER and SCAN: two novel high-prevalence antigens in the Scianna blood
RT group system.";
RL Transfusion 45:1940-1944(2005).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: Possible role as a cell-adhesion or receptor molecule of
CC erythroid cells.
CC -!- INTERACTION:
CC Q96PL5; P50402: EMD; NbExp=3; IntAct=EBI-13361852, EBI-489887;
CC Q96PL5; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-13361852, EBI-3957694;
CC Q96PL5; Q68G75: LEMD1; NbExp=3; IntAct=EBI-13361852, EBI-12268900;
CC Q96PL5; Q9Y6G1: TMEM14A; NbExp=3; IntAct=EBI-13361852, EBI-2800360;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11783959};
CC Single-pass type I membrane protein {ECO:0000255}. Cytoplasm
CC {ECO:0000269|PubMed:11783959}.
CC -!- TISSUE SPECIFICITY: Expressed in erythroid-enriched bone marrow (at
CC protein level). Highly expressed in bone marrow and to a lower extent
CC in leukocytes, thymus, lymph node and spleen.
CC {ECO:0000269|PubMed:11549310, ECO:0000269|PubMed:11783959}.
CC -!- DEVELOPMENTAL STAGE: Expressed in fetal liver blood cells (at protein
CC level). Highly expressed in fetal liver. {ECO:0000269|PubMed:11549310,
CC ECO:0000269|PubMed:11783959}.
CC -!- PTM: Glycosylated.
CC -!- POLYMORPHISM: ERMAP is responsible for the Scianna/Radin blood group
CC system which comprises seven different antigens (PubMed:12393480). The
CC Sc1 and Sc2 antigens are resulting from a single variation in position
CC 57; Arg-57 corresponds to the Sc2 antigen and Gly-57 to the Sc1
CC antigen. The Sc2 antigen is rare with an occurrence of less than 1% in
CC the population while Sc1 is more frequent. Sc3 is not expressed by
CC individuals homozygous for a null allele encoding a truncated protein
CC lacking its extracellular part (Sc-3). The Sc4 antigen corresponding to
CC the previously defined Radin blood group antigen (Rd) is due to a
CC single variation in position 60; Ala-60 corresponds to Sc4/Rd(+), the
CC antigenic form of the protein. Sc4 is found in less than 1% of the
CC population. Sc5/STAR, Sc6/SCER and Sc7/SCAN antigens are due to single
CC variations in positions 47, 81 and 35 respectively. Alloantibodies to
CC the low frequency Sc2 and Sc4 antigens are the cause of hemolytic
CC disease in the newborn (PubMed:15660834, PubMed:16371048).
CC {ECO:0000269|PubMed:12393480, ECO:0000269|PubMed:15660834,
CC ECO:0000269|PubMed:16371048}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=dbRBC/BGMUT; Note=Blood group antigen gene mutation
CC database;
CC URL="https://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=scianna";
CC -!- WEB RESOURCE: Name=SeattleSNPs;
CC URL="http://pga.gs.washington.edu/data/ermap/";
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DR EMBL; AY049028; AAL11456.1; -; mRNA.
DR EMBL; AF311284; AAL08411.1; -; mRNA.
DR EMBL; AF311285; AAL08412.1; -; mRNA.
DR EMBL; AJ505028; CAD43739.1; -; Genomic_DNA.
DR EMBL; AJ505036; CAD43740.1; -; Genomic_DNA.
DR EMBL; AJ505037; CAD43740.1; JOINED; Genomic_DNA.
DR EMBL; AJ505038; CAD43740.1; JOINED; Genomic_DNA.
DR EMBL; AJ505039; CAD43740.1; JOINED; Genomic_DNA.
DR EMBL; AJ505040; CAD43740.1; JOINED; Genomic_DNA.
DR EMBL; AJ505041; CAD43740.1; JOINED; Genomic_DNA.
DR EMBL; AJ505042; CAD43740.1; JOINED; Genomic_DNA.
DR EMBL; AJ505044; CAD43741.1; -; Genomic_DNA.
DR EMBL; AJ505045; CAD43741.1; JOINED; Genomic_DNA.
DR EMBL; AJ505046; CAD43741.1; JOINED; Genomic_DNA.
DR EMBL; AJ505047; CAD43741.1; JOINED; Genomic_DNA.
DR EMBL; AJ505048; CAD43741.1; JOINED; Genomic_DNA.
DR EMBL; AJ505049; CAD43741.1; JOINED; Genomic_DNA.
DR EMBL; AJ505050; CAD43741.1; JOINED; Genomic_DNA.
DR EMBL; BX537371; CAD97613.2; -; mRNA.
DR EMBL; DQ090843; AAY88736.1; -; Genomic_DNA.
DR EMBL; AL512353; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471059; EAX07130.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX07133.1; -; Genomic_DNA.
DR EMBL; BC099703; AAH99703.1; -; mRNA.
DR EMBL; BC099707; AAH99707.1; -; mRNA.
DR EMBL; BC099712; AAH99712.1; -; mRNA.
DR EMBL; BC099713; AAH99713.1; -; mRNA.
DR EMBL; AY644424; AAT66409.1; -; Genomic_DNA.
DR CCDS; CCDS475.1; -.
DR RefSeq; NP_001017922.1; NM_001017922.1.
DR RefSeq; NP_061008.2; NM_018538.3.
DR RefSeq; XP_006710376.1; XM_006710313.3.
DR RefSeq; XP_011538872.1; XM_011540570.2.
DR AlphaFoldDB; Q96PL5; -.
DR SMR; Q96PL5; -.
DR BioGRID; 125328; 27.
DR IntAct; Q96PL5; 18.
DR STRING; 9606.ENSP00000361595; -.
DR GlyGen; Q96PL5; 1 site.
DR iPTMnet; Q96PL5; -.
DR PhosphoSitePlus; Q96PL5; -.
DR BioMuta; ERMAP; -.
DR DMDM; 74761033; -.
DR EPD; Q96PL5; -.
DR jPOST; Q96PL5; -.
DR MassIVE; Q96PL5; -.
DR MaxQB; Q96PL5; -.
DR PaxDb; Q96PL5; -.
DR PeptideAtlas; Q96PL5; -.
DR PRIDE; Q96PL5; -.
DR ProteomicsDB; 77708; -.
DR Antibodypedia; 18175; 324 antibodies from 28 providers.
DR DNASU; 114625; -.
DR Ensembl; ENST00000372514.7; ENSP00000361592.3; ENSG00000164010.15.
DR Ensembl; ENST00000372517.8; ENSP00000361595.2; ENSG00000164010.15.
DR GeneID; 114625; -.
DR KEGG; hsa:114625; -.
DR MANE-Select; ENST00000372517.8; ENSP00000361595.2; NM_001017922.2; NP_001017922.1.
DR UCSC; uc001cic.2; human.
DR CTD; 114625; -.
DR DisGeNET; 114625; -.
DR GeneCards; ERMAP; -.
DR HGNC; HGNC:15743; ERMAP.
DR HPA; ENSG00000164010; Low tissue specificity.
DR MalaCards; ERMAP; -.
DR MIM; 111620; phenotype.
DR MIM; 111750; phenotype.
DR MIM; 609017; gene.
DR neXtProt; NX_Q96PL5; -.
DR OpenTargets; ENSG00000164010; -.
DR PharmGKB; PA27860; -.
DR VEuPathDB; HostDB:ENSG00000164010; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000160531; -.
DR InParanoid; Q96PL5; -.
DR OMA; QVMEVEN; -.
DR OrthoDB; 522383at2759; -.
DR PhylomeDB; Q96PL5; -.
DR TreeFam; TF317532; -.
DR PathwayCommons; Q96PL5; -.
DR SignaLink; Q96PL5; -.
DR SIGNOR; Q96PL5; -.
DR BioGRID-ORCS; 114625; 12 hits in 1075 CRISPR screens.
DR ChiTaRS; ERMAP; human.
DR GeneWiki; ERMAP; -.
DR GenomeRNAi; 114625; -.
DR Pharos; Q96PL5; Tbio.
DR PRO; PR:Q96PL5; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q96PL5; protein.
DR Bgee; ENSG00000164010; Expressed in monocyte and 123 other tissues.
DR ExpressionAtlas; Q96PL5; baseline and differential.
DR Genevisible; Q96PL5; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF07686; V-set; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Blood group antigen; Cell membrane; Cytoplasm; Disulfide bond;
KW Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..475
FT /note="Erythroid membrane-associated protein"
FT /id="PRO_0000226088"
FT TOPO_DOM 30..155
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 177..475
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 30..140
FT /note="Ig-like V-type"
FT DOMAIN 220..418
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT MOD_RES 418
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9JLN5"
FT CARBOHYD 132
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 50..126
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VARIANT 4
FT /note="A -> V (in dbSNP:rs35757049)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_025478"
FT VARIANT 26
FT /note="H -> Y (in dbSNP:rs33953680)"
FT /evidence="ECO:0000269|PubMed:12393480, ECO:0000269|Ref.5"
FT /id="VAR_025479"
FT VARIANT 35
FT /note="G -> S (in Sc7 antigen; dbSNP:rs146429994)"
FT /evidence="ECO:0000269|PubMed:16371048"
FT /id="VAR_025480"
FT VARIANT 47
FT /note="E -> K (in Sc5 antigen; dbSNP:rs56047316)"
FT /evidence="ECO:0000269|PubMed:15660834"
FT /id="VAR_025481"
FT VARIANT 57
FT /note="G -> R (in Sc2 antigen; dbSNP:rs56025238)"
FT /evidence="ECO:0000269|PubMed:12393480"
FT /id="VAR_025482"
FT VARIANT 60
FT /note="P -> A (in Sc4 antigen; dbSNP:rs56136737)"
FT /evidence="ECO:0000269|PubMed:12393480"
FT /id="VAR_025483"
FT VARIANT 81
FT /note="R -> Q (in Sc6 antigen; dbSNP:rs368064875)"
FT /evidence="ECO:0000269|PubMed:16371048"
FT /id="VAR_025484"
FT VARIANT 103..113
FT /note="DAQEGSVTLQI -> CPRGKCHSADP (in Sc-3 allele)"
FT /id="VAR_025485"
FT VARIANT 114..475
FT /note="Missing (in Sc-3 allele)"
FT /id="VAR_025486"
FT VARIANT 259
FT /note="C -> R (in dbSNP:rs35147822)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_025487"
FT VARIANT 263
FT /note="G -> E (in dbSNP:rs34441268)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_025488"
FT CONFLICT 452
FT /note="L -> P (in Ref. 4; CAD97613)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 475 AA; 52605 MW; D796B0951EA02E0F CRC64;
MEMASSAGSW LSGCLIPLVF LRLSVHVSGH AGDAGKFHVA LLGGTAELLC PLSLWPGTVP
KEVRWLRSPF PQRSQAVHIF RDGKDQDEDL MPEYKGRTVL VRDAQEGSVT LQILDVRLED
QGSYRCLIQV GNLSKEDTVI LQVAAPSVGS LSPSAVALAV ILPVLVLLIM VCLCLIWKQR
RAKEKLLYEH VTEVDNLLSD HAKEKGKLHK AVKKLRSELK LKRAAANSGW RRARLHFVAV
TLDPDTAHPK LILSEDQRCV RLGDRRQPVP DNPQRFDFVV SILGSEYFTT GCHYWEVYVG
DKTKWILGVC SESVSRKGKV TASPANGHWL LRQSRGNEYE ALTSPQTSFR LKEPPRCVGI
FLDYEAGVIS FYNVTNKSHI FTFTHNFSGP LRPFFEPCLH DGGKNTAPLV ICSELHKSEE
SIVPRPEGKG HANGDVSLKV NSSLLPPKAP ELKDIILSLP PDLGPALQEL KAPSF
