ID   AGRA_STAAU              Reviewed;         238 AA.
AC   P0A0I7; P13131;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Accessory gene regulator protein A;
GN   Name=agrA; Synonyms=agr;
OS   Staphylococcus aureus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2457579; DOI=10.1128/jb.170.9.4365-4372.1988;
RA   Peng H.-L., Novick R.P., Kreiswirth B., Kornblum J., Schlievert P.;
RT   "Cloning, characterization, and sequencing of an accessory gene regulator
RT   (agr) in Staphylococcus aureus.";
RL   J. Bacteriol. 170:4365-4372(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate GAL;
RX   PubMed=7565609; DOI=10.1007/bf02191645;
RA   Novick R.P., Projan S.J., Kornblum J., Ross H.F., Ji G., Kreiswirth B.,
RA   Vandenesch F., Moghazeh S.;
RT   "The agr P2 operon: an autocatalytic sensory transduction system in
RT   Staphylococcus aureus.";
RL   Mol. Gen. Genet. 248:446-458(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-114.
RC   STRAIN=KSI54, KSI9051, and RN4282;
RA   McNamara P.J., Iandolo J.J.;
RL   Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for high-level post-exponential phase expression of
CC       a series of secreted proteins.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
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DR   EMBL; M21854; AAA26597.1; -; Genomic_DNA.
DR   EMBL; X52543; CAA36784.1; -; Genomic_DNA.
DR   EMBL; U85097; AAB80782.1; -; Genomic_DNA.
DR   EMBL; U85095; AAB81231.1; -; Genomic_DNA.
DR   EMBL; U85096; AAB80778.1; -; Genomic_DNA.
DR   PIR; A32357; A32357.
DR   RefSeq; WP_000688492.1; NZ_WYDB01000007.1.
DR   PDB; 3BS1; X-ray; 1.60 A; A=137-238.
DR   PDB; 4G4K; X-ray; 1.52 A; A/B=137-238.
DR   PDBsum; 3BS1; -.
DR   PDBsum; 4G4K; -.
DR   AlphaFoldDB; P0A0I7; -.
DR   BMRB; P0A0I7; -.
DR   SMR; P0A0I7; -.
DR   IntAct; P0A0I7; 1.
DR   MINT; P0A0I7; -.
DR   BindingDB; P0A0I7; -.
DR   ChEMBL; CHEMBL1681616; -.
DR   OMA; ISVYICE; -.
DR   EvolutionaryTrace; P0A0I7; -.
DR   PHI-base; PHI:6428; -.
DR   PRO; PR:P0A0I7; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR007492; LytTR_DNA-bd_dom.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF04397; LytTR; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00850; LytTR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50930; HTH_LYTTR; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Activator; Cytoplasm; DNA-binding; Phosphoprotein;
KW   Transcription; Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..238
FT                   /note="Accessory gene regulator protein A"
FT                   /id="PRO_0000081000"
FT   DOMAIN          2..125
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          143..238
FT                   /note="HTH LytTR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00112"
FT   MOD_RES         59
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   STRAND          142..146
FT                   /evidence="ECO:0007829|PDB:4G4K"
FT   STRAND          148..155
FT                   /evidence="ECO:0007829|PDB:4G4K"
FT   HELIX           156..158
FT                   /evidence="ECO:0007829|PDB:4G4K"
FT   STRAND          159..163
FT                   /evidence="ECO:0007829|PDB:4G4K"
FT   STRAND          169..177
FT                   /evidence="ECO:0007829|PDB:4G4K"
FT   STRAND          179..182
FT                   /evidence="ECO:0007829|PDB:4G4K"
FT   HELIX           186..190
FT                   /evidence="ECO:0007829|PDB:4G4K"
FT   STRAND          196..200
FT                   /evidence="ECO:0007829|PDB:4G4K"
FT   STRAND          203..206
FT                   /evidence="ECO:0007829|PDB:4G4K"
FT   HELIX           207..209
FT                   /evidence="ECO:0007829|PDB:4G4K"
FT   STRAND          210..214
FT                   /evidence="ECO:0007829|PDB:4G4K"
FT   TURN            215..218
FT                   /evidence="ECO:0007829|PDB:4G4K"
FT   STRAND          219..222
FT                   /evidence="ECO:0007829|PDB:4G4K"
FT   STRAND          227..229
FT                   /evidence="ECO:0007829|PDB:4G4K"
FT   TURN            232..234
FT                   /evidence="ECO:0007829|PDB:4G4K"
FT   HELIX           235..237
FT                   /evidence="ECO:0007829|PDB:4G4K"
SQ   SEQUENCE   238 AA;  27906 MW;  757788C90AAFB420 CRC64;
     MKIFICEDDP KQRENMVTII KNYIMIEEKP MEIALATDNP YEVLEQAKNM NDIGCYFLDI
     QLSTDINGIK LGSEIRKHDP VGNIIFVTSH SELTYLTFVY KVAAMDFIFK DDPAELRTRI
     IDCLETAHTR LQLLSKDNSV ETIELKRGSN SVYVQYDDIM FFESSTKSHR LIAHLDNRQI
     EFYGNLKELS QLDDRFFRCH NSFVVNRHNI ESIDSKERIV YFKNKEHCYA SVRNVKKI