ID   AGRA_STAES              Reviewed;         238 AA.
AC   Q8CNM5;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Accessory gene regulator protein A;
GN   Name=agrA; OrderedLocusNames=SE_1638;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Required for high-level post-exponential phase expression of
CC       a series of secreted proteins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; AE015929; AAO05237.1; -; Genomic_DNA.
DR   RefSeq; NP_765193.1; NC_004461.1.
DR   RefSeq; WP_001829999.1; NZ_WBME01000022.1.
DR   AlphaFoldDB; Q8CNM5; -.
DR   SMR; Q8CNM5; -.
DR   STRING; 176280.SE_1638; -.
DR   EnsemblBacteria; AAO05237; AAO05237; SE_1638.
DR   GeneID; 50018262; -.
DR   KEGG; sep:SE_1638; -.
DR   PATRIC; fig|176280.10.peg.1603; -.
DR   eggNOG; COG3279; Bacteria.
DR   HOGENOM; CLU_000445_14_6_9; -.
DR   OMA; ISVYICE; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR007492; LytTR_DNA-bd_dom.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF04397; LytTR; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00850; LytTR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50930; HTH_LYTTR; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Phosphoprotein; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..238
FT                   /note="Accessory gene regulator protein A"
FT                   /id="PRO_0000081002"
FT   DOMAIN          2..125
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          143..238
FT                   /note="HTH LytTR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00112"
FT   MOD_RES         59
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   238 AA;  27937 MW;  32DF5EA3E59251E0 CRC64;
     MKIFVCEDDQ RQREHMVSII KNYIMIEEKP MELALATNDP YEVLEQSKEL NDIGCYFLDI
     QLEADMNGIK LASEIRKHDP VGNIIFVTSH SELTYLTFVY KVAAMDFIFK DDPSELKMRI
     IDCLETAHTR LKLLSKESNV DTIELKRGSN SVYVQYDDIM FFESSTKSHR LIAHLDNRQI
     EFYGNLKELA QLDERFFRCH NSFVINRHNI ESIDSKERIV YFKNGENCFA SVRNVKKI