ERN1_LOTJA
ID ERN1_LOTJA Reviewed; 269 AA.
AC A0A1X9PY88;
DT 18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2017, sequence version 1.
DT 25-MAY-2022, entry version 18.
DE RecName: Full=Ethylene-responsive transcription factor ERN1 {ECO:0000305};
DE Short=ERF transcription factor ERN1 {ECO:0000305};
DE AltName: Full=Protein ERF REQUIRED FOR NODULATION 1 {ECO:0000303|PubMed:28068194};
DE Short=LjERN1 {ECO:0000303|PubMed:28068194};
GN Name=ERN1 {ECO:0000303|PubMed:28068194};
OS Lotus japonicus (Lotus corniculatus var. japonicus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; robinioid clade; Loteae; Lotus.
OX NCBI_TaxID=34305;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=28503742; DOI=10.1111/nph.14547;
RA Cerri M.R., Wang Q., Stolz P., Folgmann J., Frances L., Katzer K., Li X.,
RA Heckmann A.B., Wang T.L., Downie J.A., Klingl A., de Carvalho-Niebel F.,
RA Xie F., Parniske M.;
RT "The ERN1 transcription factor gene is a target of the CCaMK/CYCLOPS
RT complex and controls rhizobial infection in Lotus japonicus.";
RL New Phytol. 215:323-337(2017).
RN [2]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=28028038; DOI=10.1093/dnares/dsw052;
RA Yano K., Aoki S., Liu M., Umehara Y., Suganuma N., Iwasaki W., Sato S.,
RA Soyano T., Kouchi H., Kawaguchi M.;
RT "Function and evolution of a Lotus japonicus AP2/ERF family transcription
RT factor that is required for development of infection threads.";
RL DNA Res. 24:193-203(2017).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=28068194; DOI=10.1094/mpmi-11-16-0237-r;
RA Kawaharada Y., James E.K., Kelly S., Sandal N., Stougaard J.;
RT "The ethylene responsive factor required for nodulation 1 (ERN1)
RT transcription factor is required for infection-thread formation in Lotus
RT japonicus.";
RL Mol. Plant Microbe Interact. 30:194-204(2017).
CC -!- FUNCTION: Transcription factor involved in the symbiotic nodule
CC signaling pathway in response to rhizobial stimulation. Functions as a
CC transcriptional regulator required for root infection by symbiotic
CC rhizobia, infection thread (IT) formation, and nodule development. May
CC coordinate these processes (PubMed:28503742, PubMed:28028038,
CC PubMed:28068194). Functions downstream of the CCAMK-CYCLOPS complex
CC (PubMed:28503742, PubMed:28028038). Probably not involved in arbuscular
CC mycorrhizal (AM) symbiosis (PubMed:28068194).
CC {ECO:0000269|PubMed:28028038, ECO:0000269|PubMed:28068194,
CC ECO:0000269|PubMed:28503742}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00366}.
CC -!- INDUCTION: Induced in nodules 7 days after rhizobial inoculation.
CC {ECO:0000269|PubMed:28028038, ECO:0000269|PubMed:28503742}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions, but roots of mutant plants are impaired in the interaction
CC with rhizobia, formation of infection threads (ITs) and nodule
CC development. {ECO:0000269|PubMed:28028038, ECO:0000269|PubMed:28068194,
CC ECO:0000269|PubMed:28503742}.
CC -!- SIMILARITY: Belongs to the AP2/ERF transcription factor family. ERF
CC subfamily. {ECO:0000305}.
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DR EMBL; KX858808; ARQ14732.1; -; mRNA.
DR AlphaFoldDB; A0A1X9PY88; -.
DR SMR; A0A1X9PY88; -.
DR OMA; PLACRIR; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0009877; P:nodulation; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:UniProtKB.
DR CDD; cd00018; AP2; 1.
DR Gene3D; 3.30.730.10; -; 1.
DR InterPro; IPR001471; AP2/ERF_dom.
DR InterPro; IPR036955; AP2/ERF_dom_sf.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR Pfam; PF00847; AP2; 1.
DR PRINTS; PR00367; ETHRSPELEMNT.
DR SMART; SM00380; AP2; 1.
DR SUPFAM; SSF54171; SSF54171; 1.
DR PROSITE; PS51032; AP2_ERF; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nodulation; Nucleus; Transcription; Transcription regulation.
FT CHAIN 1..269
FT /note="Ethylene-responsive transcription factor ERN1"
FT /id="PRO_0000444706"
FT DNA_BIND 34..91
FT /note="AP2/ERF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00366"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 128..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 269 AA; 30025 MW; 035C21727F0A52D3 CRC64;
MEIQFQQPNL QQHQKAGTKG GKFKGRNRNS NTNKFVGVRQ RPSGRWVAEI KDTTQKIRMW
LGTFETAEEA ARAYDEAACL LRGSNTRTNF ITHVSLDSPL ASRIRNLLNN KKGNKKQEGV
VDVGVDVDVP APSASTTSTS SNTSNSDKND HNSLSSGKVQ NTMLFDDAYK PDLSNCKEDF
QSCPPQSNFS WGFGPVFDRF PIAQILDMPK TDGMIDAASL ELSEFERMKV ERQISASLYA
INGVHEYMET VQDSNETLWD LPPLCSLFC
