ID   ERPA_ECOSM              Reviewed;         114 AA.
AC   B1LGV9;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Iron-sulfur cluster insertion protein ErpA {ECO:0000255|HAMAP-Rule:MF_01380};
GN   Name=erpA {ECO:0000255|HAMAP-Rule:MF_01380};
GN   OrderedLocusNames=EcSMS35_0168;
OS   Escherichia coli (strain SMS-3-5 / SECEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=439855;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SMS-3-5 / SECEC;
RX   PubMed=18708504; DOI=10.1128/jb.00661-08;
RA   Fricke W.F., Wright M.S., Lindell A.H., Harkins D.M., Baker-Austin C.,
RA   Ravel J., Stepanauskas R.;
RT   "Insights into the environmental resistance gene pool from the genome
RT   sequence of the multidrug-resistant environmental isolate Escherichia coli
RT   SMS-3-5.";
RL   J. Bacteriol. 190:6779-6794(2008).
CC   -!- FUNCTION: Required for insertion of 4Fe-4S clusters for at least IspG.
CC       {ECO:0000255|HAMAP-Rule:MF_01380}.
CC   -!- COFACTOR:
CC       Name=iron-sulfur cluster; Xref=ChEBI:CHEBI:30408;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01380};
CC       Note=Binds 1 iron-sulfur cluster per subunit. {ECO:0000255|HAMAP-
CC       Rule:MF_01380};
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01380}.
CC   -!- SIMILARITY: Belongs to the HesB/IscA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01380}.
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DR   EMBL; CP000970; ACB18076.1; -; Genomic_DNA.
DR   RefSeq; WP_001295564.1; NC_010498.1.
DR   AlphaFoldDB; B1LGV9; -.
DR   SMR; B1LGV9; -.
DR   EnsemblBacteria; ACB18076; ACB18076; EcSMS35_0168.
DR   GeneID; 67416233; -.
DR   KEGG; ecm:EcSMS35_0168; -.
DR   HOGENOM; CLU_069054_5_3_6; -.
DR   OMA; YQLYFDE; -.
DR   Proteomes; UP000007011; Chromosome.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProt.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.300.12; -; 1.
DR   HAMAP; MF_01380; Fe_S_insert_ErpA; 1.
DR   InterPro; IPR000361; FeS_biogenesis.
DR   InterPro; IPR016092; FeS_cluster_insertion.
DR   InterPro; IPR017870; FeS_cluster_insertion_CS.
DR   InterPro; IPR023063; FeS_cluster_insertion_RrpA.
DR   InterPro; IPR035903; HesB-like_dom_sf.
DR   Pfam; PF01521; Fe-S_biosyn; 1.
DR   SUPFAM; SSF89360; SSF89360; 1.
DR   TIGRFAMs; TIGR00049; TIGR00049; 1.
DR   PROSITE; PS01152; HESB; 1.
PE   3: Inferred from homology;
KW   Iron; Iron-sulfur; Metal-binding.
FT   CHAIN           1..114
FT                   /note="Iron-sulfur cluster insertion protein ErpA"
FT                   /id="PRO_1000144916"
FT   BINDING         42
FT                   /ligand="iron-sulfur cluster"
FT                   /ligand_id="ChEBI:CHEBI:30408"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01380"
FT   BINDING         106
FT                   /ligand="iron-sulfur cluster"
FT                   /ligand_id="ChEBI:CHEBI:30408"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01380"
FT   BINDING         108
FT                   /ligand="iron-sulfur cluster"
FT                   /ligand_id="ChEBI:CHEBI:30408"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01380"
SQ   SEQUENCE   114 AA;  12100 MW;  5A032FB5C3E0D04A CRC64;
     MSDDVALPLE FTDAAANKVK SLIADEDNPN LKLRVYITGG GCSGFQYGFT FDDQVNEGDM
     TIEKQGVGLV VDPMSLQYLV GGSVDYTEGL EGSRFIVTNP NAKSTCGCGS SFSI