ERPA_FRATT
ID ERPA_FRATT Reviewed; 116 AA.
AC Q5NGX6;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Iron-sulfur cluster insertion protein ErpA {ECO:0000255|HAMAP-Rule:MF_01380};
GN Name=erpA {ECO:0000255|HAMAP-Rule:MF_01380}; OrderedLocusNames=FTT_0700;
OS Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC Francisellaceae; Francisella.
OX NCBI_TaxID=177416;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCHU S4 / Schu 4;
RX PubMed=15640799; DOI=10.1038/ng1499;
RA Larsson P., Oyston P.C.F., Chain P., Chu M.C., Duffield M., Fuxelius H.-H.,
RA Garcia E., Haelltorp G., Johansson D., Isherwood K.E., Karp P.D.,
RA Larsson E., Liu Y., Michell S., Prior J., Prior R., Malfatti S.,
RA Sjoestedt A., Svensson K., Thompson N., Vergez L., Wagg J.K., Wren B.W.,
RA Lindler L.E., Andersson S.G.E., Forsman M., Titball R.W.;
RT "The complete genome sequence of Francisella tularensis, the causative
RT agent of tularemia.";
RL Nat. Genet. 37:153-159(2005).
CC -!- FUNCTION: Required for insertion of 4Fe-4S clusters for at least IspG.
CC {ECO:0000255|HAMAP-Rule:MF_01380}.
CC -!- COFACTOR:
CC Name=iron-sulfur cluster; Xref=ChEBI:CHEBI:30408;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01380};
CC Note=Binds 1 iron-sulfur cluster per subunit. {ECO:0000255|HAMAP-
CC Rule:MF_01380};
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01380}.
CC -!- SIMILARITY: Belongs to the HesB/IscA family. {ECO:0000255|HAMAP-
CC Rule:MF_01380}.
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DR EMBL; AJ749949; CAG45333.1; -; Genomic_DNA.
DR RefSeq; WP_003016875.1; NZ_CP010290.1.
DR RefSeq; YP_169716.1; NC_006570.2.
DR AlphaFoldDB; Q5NGX6; -.
DR SMR; Q5NGX6; -.
DR IntAct; Q5NGX6; 1.
DR STRING; 177416.FTT_0700; -.
DR DNASU; 3191027; -.
DR EnsemblBacteria; CAG45333; CAG45333; FTT_0700.
DR GeneID; 60807184; -.
DR KEGG; ftu:FTT_0700; -.
DR eggNOG; COG0316; Bacteria.
DR OMA; YQLYFDE; -.
DR Proteomes; UP000001174; Chromosome.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProt.
DR GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.300.12; -; 1.
DR HAMAP; MF_01380; Fe_S_insert_ErpA; 1.
DR InterPro; IPR000361; FeS_biogenesis.
DR InterPro; IPR016092; FeS_cluster_insertion.
DR InterPro; IPR017870; FeS_cluster_insertion_CS.
DR InterPro; IPR023063; FeS_cluster_insertion_RrpA.
DR InterPro; IPR035903; HesB-like_dom_sf.
DR Pfam; PF01521; Fe-S_biosyn; 1.
DR SUPFAM; SSF89360; SSF89360; 1.
DR TIGRFAMs; TIGR00049; TIGR00049; 1.
DR PROSITE; PS01152; HESB; 1.
PE 3: Inferred from homology;
KW Iron; Iron-sulfur; Metal-binding; Reference proteome.
FT CHAIN 1..116
FT /note="Iron-sulfur cluster insertion protein ErpA"
FT /id="PRO_0000311485"
FT BINDING 44
FT /ligand="iron-sulfur cluster"
FT /ligand_id="ChEBI:CHEBI:30408"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01380"
FT BINDING 108
FT /ligand="iron-sulfur cluster"
FT /ligand_id="ChEBI:CHEBI:30408"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01380"
FT BINDING 110
FT /ligand="iron-sulfur cluster"
FT /ligand_id="ChEBI:CHEBI:30408"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01380"
SQ SEQUENCE 116 AA; 12658 MW; C50E6B2F21904FFC CRC64;
MSEVVQSVDP INFTEAASLK VKELIEEEGD NSLSLRVYIT GGGCSGFQYA FAFDNEVKED
DMVITKNGVR LLVDSMSFQY LVGADVDYKD DVEGAYFVIR NPNAKTTCGC GSSFSV
