AGRB_STAA2
ID AGRB_STAA2 Reviewed; 187 AA.
AC A6U3C2;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Accessory gene regulator protein B {ECO:0000255|HAMAP-Rule:MF_00784};
DE EC=3.4.-.- {ECO:0000255|HAMAP-Rule:MF_00784};
GN Name=agrB {ECO:0000255|HAMAP-Rule:MF_00784};
GN OrderedLocusNames=SaurJH1_2110;
OS Staphylococcus aureus (strain JH1).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=359787;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JH1;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Ivanova N., Tomasz A., Richardson P.;
RT "Complete sequence of chromosome of Staphylococcus aureus subsp. aureus
RT JH1.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential for the production of a quorum sensing system
CC signal molecule, the autoinducing peptide (AIP). This quorum sensing
CC system is responsible for the regulation of the expression of virulence
CC factor genes. Involved in the proteolytic processing of AgrD, the
CC precursor of AIP. {ECO:0000255|HAMAP-Rule:MF_00784}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00784};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00784}.
CC -!- SIMILARITY: Belongs to the AgrB family. {ECO:0000255|HAMAP-
CC Rule:MF_00784}.
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DR EMBL; CP000736; ABR52940.1; -; Genomic_DNA.
DR RefSeq; WP_001105696.1; NC_009632.1.
DR AlphaFoldDB; A6U3C2; -.
DR MEROPS; C75.001; -.
DR KEGG; sah:SaurJH1_2110; -.
DR HOGENOM; CLU_098969_2_2_9; -.
DR OMA; MKFAIVY; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00784; AgrB; 1.
DR InterPro; IPR006741; AgrB.
DR Pfam; PF04647; AgrB; 1.
DR SMART; SM00793; AgrB; 1.
PE 3: Inferred from homology;
KW Cell membrane; Hydrolase; Membrane; Protease; Quorum sensing;
KW Transmembrane; Transmembrane helix; Virulence.
FT CHAIN 1..187
FT /note="Accessory gene regulator protein B"
FT /id="PRO_1000083586"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
SQ SEQUENCE 187 AA; 21680 MW; 22C990D0352DF7DE CRC64;
MNYFDNKIDQ FATYLQKRNN LDHIQFLQVR LGMQIIVGNF FKILVTYSIS IFLSVFLFTL
VTHLSYMLIR YNAHGAHAKS SILCYIQSIL TFVFVPYFLI NIDINFTYLL ALSIIGLISV
VIYAPAATKK QPIPIKLVKR KKYLSIIMYL LVLILSLIIH PFYAQFMLLG ILVESITLLP
IFFPKED