AGRB_STAA3
ID AGRB_STAA3 Reviewed; 189 AA.
AC Q2FF88;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Accessory gene regulator protein B {ECO:0000255|HAMAP-Rule:MF_00784};
DE EC=3.4.-.- {ECO:0000255|HAMAP-Rule:MF_00784};
GN Name=agrB {ECO:0000255|HAMAP-Rule:MF_00784};
GN OrderedLocusNames=SAUSA300_1989;
OS Staphylococcus aureus (strain USA300).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=367830;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USA300;
RX PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA Perdreau-Remington F.;
RT "Complete genome sequence of USA300, an epidemic clone of community-
RT acquired meticillin-resistant Staphylococcus aureus.";
RL Lancet 367:731-739(2006).
CC -!- FUNCTION: Essential for the production of a quorum sensing system
CC signal molecule, the autoinducing peptide (AIP). This quorum sensing
CC system is responsible for the regulation of the expression of virulence
CC factor genes. Involved in the proteolytic processing of AgrD, the
CC precursor of AIP. {ECO:0000255|HAMAP-Rule:MF_00784}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00784};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00784}.
CC -!- SIMILARITY: Belongs to the AgrB family. {ECO:0000255|HAMAP-
CC Rule:MF_00784}.
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DR EMBL; CP000255; ABD21641.1; -; Genomic_DNA.
DR RefSeq; WP_001105707.1; NZ_CP027476.1.
DR AlphaFoldDB; Q2FF88; -.
DR MEROPS; C75.001; -.
DR EnsemblBacteria; ABD21641; ABD21641; SAUSA300_1989.
DR KEGG; saa:SAUSA300_1989; -.
DR HOGENOM; CLU_098969_2_2_9; -.
DR OMA; MKFAIVY; -.
DR Proteomes; UP000001939; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00784; AgrB; 1.
DR InterPro; IPR006741; AgrB.
DR Pfam; PF04647; AgrB; 1.
DR SMART; SM00793; AgrB; 1.
PE 3: Inferred from homology;
KW Cell membrane; Hydrolase; Membrane; Protease; Quorum sensing;
KW Transmembrane; Transmembrane helix; Virulence.
FT CHAIN 1..189
FT /note="Accessory gene regulator protein B"
FT /id="PRO_1000046838"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT TRANSMEM 81..100
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
SQ SEQUENCE 189 AA; 21930 MW; 3A419DA6F3206895 CRC64;
MNYFDNKIDQ FATYLQKRNN LDHIQFLQVR LGMQVLAKNI GKLIVMYTIA YILNIFLFTL
ITNLTFYLIR RHAHGAHAPS SFWCYVESII LFILLPLVIV NFHINFLIMI ILTVISLGVI
SVYAPAATKK KPIPVRLIKR KKYYAIIVSL TLFIITLIIK EPFAQFIQLG IIIEAITLLP
IFFIKEDLK