AGRB_STAA8
ID AGRB_STAA8 Reviewed; 189 AA.
AC Q2FWM7; P21545;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Accessory gene regulator protein B {ECO:0000255|HAMAP-Rule:MF_00784};
DE EC=3.4.-.- {ECO:0000255|HAMAP-Rule:MF_00784};
GN Name=agrB {ECO:0000255|HAMAP-Rule:MF_00784};
GN OrderedLocusNames=SAOUHSC_02261;
OS Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93061;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2622452; DOI=10.1007/bf00259623;
RA Janzon L., Loefdahl S., Arvidson S.;
RT "Identification and nucleotide sequence of the delta-lysin gene, hld,
RT adjacent to the accessory gene regulator (agr) of Staphylococcus aureus.";
RL Mol. Gen. Genet. 219:480-485(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Bischoff M.;
RT "DNA for hld, agrB, and agrD genes of Staphylococcus aureus strain
RT RN4220.";
RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 8325 / PS 47;
RA Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT "The Staphylococcus aureus NCTC 8325 genome.";
RL (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL D.C. (2006).
CC -!- FUNCTION: Essential for the production of a quorum sensing system
CC signal molecule, the autoinducing peptide (AIP). This quorum sensing
CC system is responsible for the regulation of the expression of virulence
CC factor genes. Involved in the proteolytic processing of AgrD, the
CC precursor of AIP. {ECO:0000255|HAMAP-Rule:MF_00784}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00784};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00784}.
CC -!- SIMILARITY: Belongs to the AgrB family. {ECO:0000255|HAMAP-
CC Rule:MF_00784}.
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DR EMBL; AF230358; AAF43205.1; -; Genomic_DNA.
DR EMBL; CP000253; ABD31300.1; -; Genomic_DNA.
DR RefSeq; WP_001105707.1; NZ_LS483365.1.
DR RefSeq; YP_500743.1; NC_007795.1.
DR AlphaFoldDB; Q2FWM7; -.
DR STRING; 1280.SAXN108_2129; -.
DR MEROPS; C75.001; -.
DR EnsemblBacteria; ABD31300; ABD31300; SAOUHSC_02261.
DR GeneID; 3919137; -.
DR KEGG; sao:SAOUHSC_02261; -.
DR PATRIC; fig|93061.5.peg.2054; -.
DR eggNOG; COG4512; Bacteria.
DR HOGENOM; CLU_098969_2_2_9; -.
DR OMA; MKFAIVY; -.
DR PRO; PR:Q2FWM7; -.
DR Proteomes; UP000008816; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00784; AgrB; 1.
DR InterPro; IPR006741; AgrB.
DR Pfam; PF04647; AgrB; 1.
DR SMART; SM00793; AgrB; 1.
PE 3: Inferred from homology;
KW Cell membrane; Hydrolase; Membrane; Protease; Quorum sensing;
KW Reference proteome; Transmembrane; Transmembrane helix; Virulence.
FT CHAIN 1..189
FT /note="Accessory gene regulator protein B"
FT /id="PRO_0000247438"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT TRANSMEM 81..100
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
SQ SEQUENCE 189 AA; 21930 MW; 3A419DA6F3206895 CRC64;
MNYFDNKIDQ FATYLQKRNN LDHIQFLQVR LGMQVLAKNI GKLIVMYTIA YILNIFLFTL
ITNLTFYLIR RHAHGAHAPS SFWCYVESII LFILLPLVIV NFHINFLIMI ILTVISLGVI
SVYAPAATKK KPIPVRLIKR KKYYAIIVSL TLFIITLIIK EPFAQFIQLG IIIEAITLLP
IFFIKEDLK