ID   AGRB_STAAM              Reviewed;         187 AA.
AC   P61636; O33585;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Accessory gene regulator protein B {ECO:0000255|HAMAP-Rule:MF_00784};
DE            EC=3.4.-.- {ECO:0000255|HAMAP-Rule:MF_00784};
GN   Name=agrB {ECO:0000255|HAMAP-Rule:MF_00784}; OrderedLocusNames=SAV2036;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Essential for the production of a quorum sensing system
CC       signal molecule, the autoinducing peptide (AIP). This quorum sensing
CC       system is responsible for the regulation of the expression of virulence
CC       factor genes. Involved in the proteolytic processing of AgrD, the
CC       precursor of AIP. {ECO:0000255|HAMAP-Rule:MF_00784}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00784};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00784}.
CC   -!- SIMILARITY: Belongs to the AgrB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00784}.
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DR   EMBL; BA000017; BAB58198.1; -; Genomic_DNA.
DR   RefSeq; WP_001105696.1; NC_002758.2.
DR   AlphaFoldDB; P61636; -.
DR   MEROPS; C75.001; -.
DR   PaxDb; P61636; -.
DR   EnsemblBacteria; BAB58198; BAB58198; SAV2036.
DR   KEGG; sav:SAV2036; -.
DR   HOGENOM; CLU_098969_2_2_9; -.
DR   OMA; MKFAIVY; -.
DR   PhylomeDB; P61636; -.
DR   BioCyc; SAUR158878:SAV_RS11115-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00784; AgrB; 1.
DR   InterPro; IPR006741; AgrB.
DR   Pfam; PF04647; AgrB; 1.
DR   SMART; SM00793; AgrB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Membrane; Protease; Quorum sensing;
KW   Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..187
FT                   /note="Accessory gene regulator protein B"
FT                   /id="PRO_0000168120"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
SQ   SEQUENCE   187 AA;  21680 MW;  22C990D0352DF7DE CRC64;
     MNYFDNKIDQ FATYLQKRNN LDHIQFLQVR LGMQIIVGNF FKILVTYSIS IFLSVFLFTL
     VTHLSYMLIR YNAHGAHAKS SILCYIQSIL TFVFVPYFLI NIDINFTYLL ALSIIGLISV
     VIYAPAATKK QPIPIKLVKR KKYLSIIMYL LVLILSLIIH PFYAQFMLLG ILVESITLLP
     IFFPKED