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ERP_MYCBO
ID   ERP_MYCBO               Reviewed;         284 AA.
AC   P0A5P5; A0A1R3Y5A2; O53586; Q50793; Q53468; X2BPB4;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Exported repetitive protein;
DE   AltName: Full=Cell surface protein PirG;
DE   AltName: Full=EXP53;
DE   Flags: Precursor;
GN   Name=erp; Synonyms=pirG; OrderedLocusNames=BQ2027_MB3840;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Surface-exposed protein required for multiplication and
CC       intracellular growth. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: To M.leprae 28 kDa antigen. {ECO:0000305}.
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DR   EMBL; LT708304; SIU02469.1; -; Genomic_DNA.
DR   RefSeq; NP_857477.1; NC_002945.3.
DR   RefSeq; WP_003420801.1; NC_002945.4.
DR   AlphaFoldDB; P0A5P5; -.
DR   EnsemblBacteria; SIU02469; SIU02469; BQ2027_MB3840.
DR   PATRIC; fig|233413.5.peg.4198; -.
DR   OMA; NKAPEHH; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008164; XGLTT_repeat.
DR   Pfam; PF01744; GLTT; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..284
FT                   /note="Exported repetitive protein"
FT                   /id="PRO_0000021200"
FT   TOPO_DOM        23..252
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        274..284
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REPEAT          92..96
FT                   /note="1-1"
FT   REPEAT          97..101
FT                   /note="1-2"
FT   REPEAT          102..106
FT                   /note="1-3"
FT   REPEAT          107..111
FT                   /note="1-4"
FT   REPEAT          112..116
FT                   /note="1-5"
FT   REPEAT          117..121
FT                   /note="1-6"
FT   REPEAT          144..148
FT                   /note="2-1"
FT   REPEAT          149..153
FT                   /note="2-2"
FT   REPEAT          154..158
FT                   /note="2-3"
FT   REPEAT          159..163
FT                   /note="2-4"
FT   REPEAT          164..168
FT                   /note="2-5"
FT   REPEAT          169..173
FT                   /note="2-6"
FT   REGION          80..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          92..121
FT                   /note="6 X 5 AA tandem repeats of P-[GA]-L-T-S"
FT   REGION          144..173
FT                   /note="6 X 5 AA approximate tandem repeats of P-[ATG]-[LG]-
FT                   X-X"
FT   COMPBIAS        80..122
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..162
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   284 AA;  27700 MW;  1164C7FE3E7ADE42 CRC64;
     MPNRRRRKLS TAMSAVAALA VASPCAYFLV YESTETTERP EHHEFKQAAV LTDLPGELMS
     ALSQGLSQFG INIPPVPSLT GSGDASTGLT GPGLTSPGLT SPGLTSPGLT DPALTSPGLT
     PTLPGSLAAP GTTLAPTPGV GANPALTNPA LTSPTGATPG LTSPTGLDPA LGGANEIPIT
     TPVGLDPGAD GTYPILGDPT LGTIPSSPAT TSTGGGGLVN DVMQVANELG ASQAIDLLKG
     VLMPSIMQAV QNGGAAAPAA SPPVPPIPAA AAVPPTDPIT VPVA
 
 
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