ERP_MYCTO
ID ERP_MYCTO Reviewed; 284 AA.
AC P9WIQ6; L0TDV1; O53586; P0A5P4; Q50793; Q53468;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 30.
DE RecName: Full=Exported repetitive protein;
DE AltName: Full=Cell surface protein PirG;
DE AltName: Full=EXP53;
DE Flags: Precursor;
GN Name=erp; Synonyms=pirG; OrderedLocusNames=MT3917;
OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83331;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
CC -!- FUNCTION: Surface-exposed protein required for multiplication and
CC intracellular growth. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: To M.leprae 28 kDa antigen. {ECO:0000305}.
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DR EMBL; AE000516; AAK48283.1; -; Genomic_DNA.
DR PIR; F70888; F70888.
DR RefSeq; WP_003420801.1; NZ_KK341227.1.
DR AlphaFoldDB; P9WIQ6; -.
DR EnsemblBacteria; AAK48283; AAK48283; MT3917.
DR KEGG; mtc:MT3917; -.
DR PATRIC; fig|83331.31.peg.4214; -.
DR HOGENOM; CLU_063439_0_0_11; -.
DR Proteomes; UP000001020; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR008164; XGLTT_repeat.
DR Pfam; PF01744; GLTT; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..284
FT /note="Exported repetitive protein"
FT /id="PRO_0000427963"
FT TOPO_DOM 23..252
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 274..284
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 92..96
FT /note="1-1"
FT REPEAT 97..101
FT /note="1-2"
FT REPEAT 102..106
FT /note="1-3"
FT REPEAT 107..111
FT /note="1-4"
FT REPEAT 112..116
FT /note="1-5"
FT REPEAT 117..121
FT /note="1-6"
FT REPEAT 144..148
FT /note="2-1"
FT REPEAT 149..153
FT /note="2-2"
FT REPEAT 154..158
FT /note="2-3"
FT REPEAT 159..163
FT /note="2-4"
FT REPEAT 164..168
FT /note="2-5"
FT REPEAT 169..173
FT /note="2-6"
FT REGION 80..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 92..121
FT /note="6 X 5 AA tandem repeats of P-[GA]-L-T-S"
FT REGION 144..173
FT /note="6 X 5 AA approximate tandem repeats of P-[ATG]-[LG]-
FT X-X"
FT COMPBIAS 80..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 284 AA; 27700 MW; 1164C7FE3E7ADE42 CRC64;
MPNRRRRKLS TAMSAVAALA VASPCAYFLV YESTETTERP EHHEFKQAAV LTDLPGELMS
ALSQGLSQFG INIPPVPSLT GSGDASTGLT GPGLTSPGLT SPGLTSPGLT DPALTSPGLT
PTLPGSLAAP GTTLAPTPGV GANPALTNPA LTSPTGATPG LTSPTGLDPA LGGANEIPIT
TPVGLDPGAD GTYPILGDPT LGTIPSSPAT TSTGGGGLVN DVMQVANELG ASQAIDLLKG
VLMPSIMQAV QNGGAAAPAA SPPVPPIPAA AAVPPTDPIT VPVA
