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ERR3_RAT
ID   ERR3_RAT                Reviewed;         458 AA.
AC   P62510; Q5QJE4; Q75T51; Q75T52;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=Estrogen-related receptor gamma;
DE   AltName: Full=Estrogen receptor-related protein 3;
DE   AltName: Full=Nuclear receptor subfamily 3 group B member 3;
GN   Name=Esrrg; Synonyms=Errg, Nr3b3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RA   Razzaque M.A., Masuda N., Maeda Y., Endo Y., Tsukamoto T., Osumi T.;
RT   "Specificity of binding sequence recognition of estrogen receptor-related
RT   receptor gamma.";
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   STRAIN=Noble;
RA   Lui K., Chen S., Chan F.L.;
RT   "Molecular cloning and expression study of estrogen receptor-related
RT   receptor gamma in rat prostate.";
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Orphan receptor that acts as transcription activator in the
CC       absence of bound ligand. Binds specifically to an estrogen response
CC       element and activates reporter genes controlled by estrogen response
CC       elements. Induces the expression of PERM1 in the skeletal muscle (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with NRIP1, NCOA1 and NCOR2. Binds TLE1,
CC       PNRC1 and PNRC2. Binds GRIP1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=Errg-1, Long;
CC         IsoId=P62510-1; Sequence=Displayed;
CC       Name=2; Synonyms=Errg-2, Short;
CC         IsoId=P62510-2; Sequence=VSP_010767;
CC   -!- PTM: Acetylated by PCAF/KAT2 (in vitro). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AB126962; BAD08616.1; -; mRNA.
DR   EMBL; AB126963; BAD08617.1; -; mRNA.
DR   EMBL; AY341057; AAQ90023.1; -; mRNA.
DR   RefSeq; NP_976081.1; NM_203336.2. [P62510-2]
DR   RefSeq; XP_006250505.1; XM_006250443.3. [P62510-1]
DR   RefSeq; XP_017454353.1; XM_017598864.1. [P62510-2]
DR   RefSeq; XP_017454354.1; XM_017598865.1. [P62510-2]
DR   RefSeq; XP_017454355.1; XM_017598866.1. [P62510-2]
DR   RefSeq; XP_017454356.1; XM_017598867.1. [P62510-2]
DR   RefSeq; XP_017454357.1; XM_017598868.1. [P62510-2]
DR   RefSeq; XP_017454358.1; XM_017598869.1. [P62510-2]
DR   RefSeq; XP_017454359.1; XM_017598870.1. [P62510-2]
DR   AlphaFoldDB; P62510; -.
DR   SMR; P62510; -.
DR   STRING; 10116.ENSRNOP00000003489; -.
DR   PhosphoSitePlus; P62510; -.
DR   PaxDb; P62510; -.
DR   Ensembl; ENSRNOT00000003489; ENSRNOP00000003489; ENSRNOG00000002593. [P62510-1]
DR   GeneID; 360896; -.
DR   KEGG; rno:360896; -.
DR   UCSC; RGD:1303236; rat. [P62510-1]
DR   CTD; 2104; -.
DR   RGD; 1303236; Esrrg.
DR   eggNOG; KOG3575; Eukaryota.
DR   GeneTree; ENSGT00940000153433; -.
DR   HOGENOM; CLU_007368_11_0_1; -.
DR   InParanoid; P62510; -.
DR   OMA; MDPVELC; -.
DR   OrthoDB; 669799at2759; -.
DR   PhylomeDB; P62510; -.
DR   TreeFam; TF323751; -.
DR   Reactome; R-RNO-383280; Nuclear Receptor transcription pathway.
DR   PRO; PR:P62510; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Bgee; ENSRNOG00000002593; Expressed in stomach and 14 other tissues.
DR   Genevisible; P62510; RN.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0050682; F:AF-2 domain binding; ISS:UniProtKB.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR   GO; GO:0034056; F:estrogen response element binding; ISO:RGD.
DR   GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR   GO; GO:0003707; F:nuclear steroid receptor activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:RGD.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR   GO; GO:0005496; F:steroid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; ISS:YuBioLab.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0048384; P:retinoic acid receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR024178; Est_rcpt/est-rel_rcp.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR027289; Oest-rel_rcp.
DR   InterPro; IPR003078; Retinoic_acid_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PIRSF; PIRSF002527; ER-like_NR; 1.
DR   PIRSF; PIRSF500939; ERR1-2-3; 1.
DR   PRINTS; PR01292; RETNOICACIDR.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Activator; Alternative splicing; DNA-binding; Metal-binding;
KW   Nucleus; Receptor; Reference proteome; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..458
FT                   /note="Estrogen-related receptor gamma"
FT                   /id="PRO_0000053668"
FT   DOMAIN          233..457
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        125..200
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         128..148
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         164..188
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          42..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        42..80
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..23
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_010767"
FT   CONFLICT        276
FT                   /note="L -> W (in Ref. 2; AAQ90023)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   458 AA;  51306 MW;  63D36CFD37573152 CRC64;
     MDSVELCLPE SFSLHYEEEL LCRMSNKDRH IDSSCSSFIK TEPSSPASLT DSVNHHSPGG
     SSDASGSYSS TMNGHQNGLD SPPLYPSAPI LGGSGPVRKL YDDCSSTIVE DPQTKCEYML
     NSMPKRLCLV CGDIASGYHY GVASCEACKA FFKRTIQGNI EYSCPATNEC EITKRRRKSC
     QACRFMKCLK VGMLKEGVRL DRVRGGRQKY KRRIDAENSP YLNPQLVQPA KKPYNKIVSH
     LLVAEPEKIY AMPDPTVPDS DIKALTTLCD LADRELVVII GWAKHIPGFS TLSLADQMSL
     LQSAWMEILI LGVVYRSLSF EDELVYADDY IMDEDQSKLA GLLDLNNAIL QLVKKYKSMK
     LEKEEFVTLK AIALANSDSM HIEDVEAVQK LQDVLHEALQ DYEAGQHMED PRRAGKMLMT
     LPLLRQTSTK AVQHFYNIKL EGKVPMHKLF LEMLEAKV
 
 
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