ERS2_ORYSI
ID ERS2_ORYSI Reviewed; 635 AA.
AC B8AY75; Q8W129;
DT 16-SEP-2015, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Probable ethylene response sensor 2 {ECO:0000305};
DE Short=OS-ERS2 {ECO:0000303|PubMed:14754915};
DE EC=2.7.13.3 {ECO:0000305};
DE AltName: Full=Ethylene response factor 2 {ECO:0000303|PubMed:14754915};
GN Name=ERS2 {ECO:0000312|EMBL:AAL66363.1};
GN ORFNames=OsI_18521 {ECO:0000312|EMBL:EEC78552.1};
OS Oryza sativa subsp. indica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39946;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=cv. IR36;
RX PubMed=14754915; DOI=10.1093/jxb/erh055;
RA Yau C.P., Wang L., Yu M., Zee S.Y., Yip W.K.;
RT "Differential expression of three genes encoding an ethylene receptor in
RT rice during development, and in response to indole-3-acetic acid and silver
RT ions.";
RL J. Exp. Bot. 55:547-556(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 93-11;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
CC -!- FUNCTION: Ethylene receptor related to bacterial two-component
CC regulators. Acts as negative regulator of ethylene signaling. May play
CC a role in the regulation of flowering by up-regulating GI (GIGANTEA)
CC and RCN1 and regulate starch accumulation by down-regulating the alpha-
CC amylase AMY3D. {ECO:0000250|UniProtKB:Q0DKM0}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000305};
CC -!- COFACTOR:
CC Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC Evidence={ECO:0000250|UniProtKB:P49333};
CC Note=Binds 1 copper ion per dimer. {ECO:0000250|UniProtKB:P49333};
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P49333}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:P49333}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in anthers and hulls.
CC {ECO:0000269|PubMed:14754915}.
CC -!- SIMILARITY: Belongs to the ethylene receptor family. {ECO:0000305}.
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DR EMBL; AF460181; AAL66363.1; -; mRNA.
DR EMBL; CM000130; EEC78552.1; -; Genomic_DNA.
DR AlphaFoldDB; B8AY75; -.
DR SMR; B8AY75; -.
DR STRING; 39946.B8AY75; -.
DR EnsemblPlants; BGIOSGA018780-TA; BGIOSGA018780-PA; BGIOSGA018780.
DR Gramene; BGIOSGA018780-TA; BGIOSGA018780-PA; BGIOSGA018780.
DR HOGENOM; CLU_000445_114_48_1; -.
DR OMA; HLADWCL; -.
DR Proteomes; UP000007015; Chromosome 5.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0009873; P:ethylene-activated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF47384; SSF47384; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Copper; Disulfide bond; Endoplasmic reticulum;
KW Ethylene signaling pathway; Kinase; Membrane; Metal-binding;
KW Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome;
KW Transferase; Transmembrane; Transmembrane helix;
KW Two-component regulatory system.
FT CHAIN 1..635
FT /note="Probable ethylene response sensor 2"
FT /id="PRO_0000433864"
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 159..308
FT /note="GAF"
FT /evidence="ECO:0000305"
FT DOMAIN 351..589
FT /note="Histidine kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT BINDING 66
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000250|UniProtKB:P49333"
FT BINDING 70
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000250|UniProtKB:P49333"
FT MOD_RES 354
FT /note="Phosphohistidine; by autocatalysis"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT DISULFID 5
FT /note="Interchain"
FT /evidence="ECO:0000250|UniProtKB:P49333"
FT DISULFID 7
FT /note="Interchain"
FT /evidence="ECO:0000250|UniProtKB:P49333"
FT CONFLICT 345
FT /note="R -> C (in Ref. 1; AAL66363)"
FT /evidence="ECO:0000305"
FT CONFLICT 443
FT /note="V -> M (in Ref. 1; AAL66363)"
FT /evidence="ECO:0000305"
FT CONFLICT 491
FT /note="D -> H (in Ref. 1; AAL66363)"
FT /evidence="ECO:0000305"
FT CONFLICT 510
FT /note="F -> L (in Ref. 1; AAL66363)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 635 AA; 70458 MW; E6F5DBD007582413 CRC64;
MDGSCDCIEP LWQADDLLVK YQYISDFFIA LAYFSIPLEL IYFVKKSAFF PYRWVLIQFG
AFIVLCGATH LINLWTFAIY TKTIAVVLTV AKAATAVVSC ITALMLVHII PDLLNVKLRE
RFLKDKADEL DREMGIIRTQ EETGRHVHML THEIRSTLDR HTILRTTLVE LGRTLALAEC
ALWMPTRSGS ALQLSHTIYN SAAIGSVVPI NLPIVSKVFN SNRVVKIPHT SPLASITADK
SRYVPPEVVA IRVPLLHLTN FQINDWPELS AKSFAVMVLM LPPDSAREWR PHERELVEVV
ADQVAVALSH AAILEESMRA RDLLMEQNIA LDAARREAEM AICARNDFLA VMNHEMRTPM
RAIVSLSSLL LETNLSAEQR LMVETILKSS DLLATLTNDV LDVSKLENGS LELEIAPFNL
HSTFTDVVNL IKPVAACKRL SVVVTLAPEL PLHAIGDQKR LMQIILNVAG NSIKFTKEGH
VSITASMARP DALRGPHEPD YHPVVSDGFF YLAVQVKDTG CGISPQDMPH TFRKFAHPEN
AGKWNSGSGL GLALSRRFVS LMEGNIWLES EGVGKGCTAM FFVKLGMPEK PNANLRRMAP
HPLQPNQGAG GPDALSISIM DSNPRVPRVR YQSSV
