ID   ERT11_YARLI             Reviewed;         354 AA.
AC   Q6C5G3;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Transcription activator of gluconeogenesis ERT1-1;
GN   Name=ERT1-1; OrderedLocusNames=YALI0E18304g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; CR382131; CAG79694.1; -; Genomic_DNA.
DR   RefSeq; XP_504099.1; XM_504099.1.
DR   AlphaFoldDB; Q6C5G3; -.
DR   SMR; Q6C5G3; -.
DR   STRING; 284591.Q6C5G3; -.
DR   EnsemblFungi; CAG79694; CAG79694; YALI0_E18304g.
DR   GeneID; 2911712; -.
DR   KEGG; yli:YALI0E18304g; -.
DR   VEuPathDB; FungiDB:YALI0_E18304g; -.
DR   HOGENOM; CLU_010748_2_1_1; -.
DR   InParanoid; Q6C5G3; -.
DR   OMA; DEMSANG; -.
DR   Proteomes; UP000001300; Chromosome E.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:EnsemblFungi.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0009267; P:cellular response to starvation; IBA:GO_Central.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0061415; P:negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source; IEA:EnsemblFungi.
DR   GO; GO:0061414; P:positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source; IEA:EnsemblFungi.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..354
FT                   /note="Transcription activator of gluconeogenesis ERT1-1"
FT                   /id="PRO_0000406471"
FT   DNA_BIND        32..60
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          71..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          128..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        78..100
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   354 AA;  39357 MW;  ECF28A366ED75F84 CRC64;
     MSFYPILRGP AKQESPPPPP APKKRRKTAR ACLHCQKAHL TCDEGRPCAR CIKKNMGDQC
     VDGKRKQAKY LVGLPPTPPG QATQQKQQQQ QQQQQAVQHG MGPPDTDFGS SAANLEYSIL
     SNILGRGDTS SPPDFFPAQS PHMPSPMSIP GLHMEEEGSQ TAGTPQGSPT DIYTSITKPY
     AYTTGFHALI AYLKSRFEKK ELLDVVKSMA FYRPSFIATT QTLQYEDLVF MEKCFQRTLL
     EFEKYISLSG TPTVLWRRTG QIAAVGKEFC VLTMRSQADL LSQFIIECMD NKSVVQYFDV
     FSELAFEDSR GTITTTFGLT KPSGEVVNTA CSLTIKRDVF DIPMMIVGNF LPIL