ID   ERT12_YARLI             Reviewed;         559 AA.
AC   Q6C764;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Transcription activator of gluconeogenesis ERT1-2;
GN   Name=ERT1-2; OrderedLocusNames=YALI0E03410g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382131; CAG79077.1; -; Genomic_DNA.
DR   RefSeq; XP_503498.1; XM_503498.1.
DR   AlphaFoldDB; Q6C764; -.
DR   STRING; 284591.Q6C764; -.
DR   EnsemblFungi; CAG79077; CAG79077; YALI0_E03410g.
DR   GeneID; 2912149; -.
DR   KEGG; yli:YALI0E03410g; -.
DR   VEuPathDB; FungiDB:YALI0_E03410g; -.
DR   HOGENOM; CLU_010748_2_3_1; -.
DR   InParanoid; Q6C764; -.
DR   OMA; FNETRRN; -.
DR   Proteomes; UP000001300; Chromosome E.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0009267; P:cellular response to starvation; IBA:GO_Central.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..559
FT                   /note="Transcription activator of gluconeogenesis ERT1-2"
FT                   /id="PRO_0000406472"
FT   DOMAIN          440..512
FT                   /note="PAS"
FT   DNA_BIND        23..51
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          63..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          231..263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          329..349
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..159
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   559 AA;  61447 MW;  DA57240C9E634D0B CRC64;
     MEKPVVISQR TGKPKRRKAH RACIHCQRTH LTCDNNRPCE RCVARGFADT CVDGVRKKLK
     YLDDKEDNKP SKGLSPAPGV NVQPKLSPAT RSARSSSAGF PDTKGNMQQQ HMGNMPVPNT
     PQNGHPNLGT PGMAHTNLQG PQRQGAQQPQ GGQSSTPSQL PADYLIHQQL LATEINQLGD
     LGRTGEGDFS SDWFSDLQLS GHSFQSVATN MEYSILSNMV YSSGQPNSAV SNSLLLGNNS
     QSPNTHSPHN QDQPTPQAAT PSAKIKQLIE SNGLSAKDLN QYPLAGEFVN DTFLTVPEIV
     AFNETRRNVK DSELTTDEKL RPLSFAVAAG QPQNTNGNGN GSEAPDSPSK SIFSSGALEA
     VYSNLPDYTD PIQVYTNITK PFSYTPGYHG LISYLKGRFN KQQLVQMTKY MAEYRPSFIA
     CTNSLKEEDL VFMEQCFQRA LLEYQKFISF SGTPTLVWRR TGQLAAVGKE FCQLSGWSEQ
     RLIGQQTFIV ELLDDNSVLE YFELFSRIAF GDSRGATMAD CTLLTPTGAK IKTSSIWTLK
     RDVFGNPMMI VGNFLPILS