ID   ERT1_CANAW              Reviewed;         561 AA.
AC   C4YLC3;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Transcription activator of gluconeogenesis ERT1;
GN   Name=ERT1; ORFNames=CAWG_01641;
OS   Candida albicans (strain WO-1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294748;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WO-1;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; CM000309; EEQ43404.1; -; Genomic_DNA.
DR   AlphaFoldDB; C4YLC3; -.
DR   SMR; C4YLC3; -.
DR   STRING; 5476.C4YLC3; -.
DR   EnsemblFungi; EEQ43404; EEQ43404; CAWG_01641.
DR   VEuPathDB; FungiDB:CAWG_01641; -.
DR   HOGENOM; CLU_010748_2_3_1; -.
DR   OMA; DEMSANG; -.
DR   Proteomes; UP000001429; Chromosome R.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50112; PAS; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..561
FT                   /note="Transcription activator of gluconeogenesis ERT1"
FT                   /id="PRO_0000406457"
FT   DOMAIN          440..514
FT                   /note="PAS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT   DNA_BIND        34..62
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          61..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          222..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..151
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   561 AA;  63499 MW;  3CFA08B501D8A86E CRC64;
     MKIKQENITN TTSINTSNVN DKPKPKRKKT SRACNHCHKA HMTCDSGRPC KRCIQRGLDS
     TCEDAPRKRK KYLQDVPNSS LMSNHSMNSS DNLDSNGVSP MQPTLSQPMP PVQESSLPTN
     IPNQSQVPSQ SPNTASQKQL SYSPPLASTY SPNHKTYSAT LFQHSATSPE LMQTVPEYFP
     ELYNQHYQPS ANPNQKRRTN FLSTAADLEY STLSNILQEN FGHHTTSNEG TPNSHNFSPA
     LSPHNMPTNN TNAPSTSTQL LTNDQQRQAT SFNNHTKHNT PSPLNTSHTK LYEDARYPKC
     DETINQYFLG DTDSGKMVVF PDVLTAIENM KNNDPAVYLE RNSKSALSFV MSIQHENNSN
     GGKEDQLFKE PEEIYEKVKK PFSYTPGYHS LIAYLRKRFT KPMLVKMAES MATYRPSFIA
     CTNSLKEHDL IFMEQCFQRT LLTYDNYIKI SGTPTIVWRR TGEVAYVGNE FCVLTGWPKE
     ELIGKDKRKF IVELLDDKSV LQYFQVFSRI AFGDFLGATM TECTLLTPNP NVKIRTGCMW
     TLKRDVFGIP MMIVGNFLPI L