ID   ERT1_CANDC              Reviewed;         560 AA.
AC   B9WLA7;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Transcription activator of gluconeogenesis ERT1;
GN   Name=ERT1; ORFNames=CD36_28150;
OS   Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 /
OS   NRRL Y-17841) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=573826;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841;
RX   PubMed=19745113; DOI=10.1101/gr.097501.109;
RA   Jackson A.P., Gamble J.A., Yeomans T., Moran G.P., Saunders D., Harris D.,
RA   Aslett M., Barrell J.F., Butler G., Citiulo F., Coleman D.C.,
RA   de Groot P.W.J., Goodwin T.J., Quail M.A., McQuillan J., Munro C.A.,
RA   Pain A., Poulter R.T., Rajandream M.A., Renauld H., Spiering M.J.,
RA   Tivey A., Gow N.A.R., Barrell B., Sullivan D.J., Berriman M.;
RT   "Comparative genomics of the fungal pathogens Candida dubliniensis and
RT   Candida albicans.";
RL   Genome Res. 19:2231-2244(2009).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; FM992695; CAX39812.1; -; Genomic_DNA.
DR   RefSeq; XP_002421868.1; XM_002421823.1.
DR   AlphaFoldDB; B9WLA7; -.
DR   SMR; B9WLA7; -.
DR   STRING; 42374.XP_002421868.1; -.
DR   EnsemblFungi; CAX39812; CAX39812; CD36_28150.
DR   GeneID; 8049537; -.
DR   KEGG; cdu:CD36_28150; -.
DR   CGD; CAL0000166739; Cd36_28150.
DR   VEuPathDB; FungiDB:CD36_28150; -.
DR   eggNOG; ENOG502R1M5; Eukaryota.
DR   HOGENOM; CLU_010748_2_3_1; -.
DR   OrthoDB; 681770at2759; -.
DR   Proteomes; UP000002605; Chromosome R.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50112; PAS; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..560
FT                   /note="Transcription activator of gluconeogenesis ERT1"
FT                   /id="PRO_0000406458"
FT   DOMAIN          439..513
FT                   /note="PAS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT   DNA_BIND        34..62
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          75..149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          222..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..149
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   560 AA;  63191 MW;  F29A17A06D7AE537 CRC64;
     MNIEQENITN TTLTNTNNVN DKPKPKRKKT SRACNHCHKA HMTCDPGRPC QRCIQRGLGS
     TCEDAPRKRK KYLEDVPNSS LMSSHSINSS DHLDSNGVTP MQSTLSLPMP PVQESPFSTS
     APTQSQVPAY TPSTVPQRQP SYSPQVASNY SPNHKTYSAT LFQHSATSPE LMQTVPEYFP
     ELHNQHYQPS ANPNQKRRTN FLSTAADLEY STLSNILQEN FGHHTTSNEG TPNSHNFSPA
     LSPHNMPTTD TNAPPPSIQL ASNDQRQVTS FNNHTKHSTP SPLNTSQTKL YEDARYPKCD
     ETINQYFLGD TESGKMVVFP DVLTAIENMK NNDPAVYVER NSKSTLSFAM SISHESNSNN
     GKDGQLFKEP EEIYEKVKKP FSYTPGYHSL IAYLRKRFTK PMLVKMAESM ATYRPSFIAC
     TNSLKEHDLI FMEQCFQRTL LTYDNYIKIS GTPTIVWRRT GEVAYVGNEF CVLTGWPKEE
     LIGKDKRKFI VELLDDKSVL QYFQVFSRIA FGDFLGATMT ECTLLTPNPN VKIRTGCMWT
     LKRDVFGIPM MIVGNFLPIL