ID   ERT1_CANGA              Reviewed;         596 AA.
AC   Q6FML7;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Transcription activator of gluconeogenesis ERT1;
GN   Name=ERT1; OrderedLocusNames=CAGL0K06985g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; CR380957; CAG61488.1; -; Genomic_DNA.
DR   RefSeq; XP_448527.1; XM_448527.1.
DR   AlphaFoldDB; Q6FML7; -.
DR   STRING; 5478.XP_448527.1; -.
DR   EnsemblFungi; CAG61488; CAG61488; CAGL0K06985g.
DR   GeneID; 2890386; -.
DR   KEGG; cgr:CAGL0K06985g; -.
DR   CGD; CAL0133843; CAGL0K06985g.
DR   VEuPathDB; FungiDB:CAGL0K06985g; -.
DR   eggNOG; ENOG502R1M5; Eukaryota.
DR   HOGENOM; CLU_010748_2_3_1; -.
DR   InParanoid; Q6FML7; -.
DR   OMA; VMTTCKL; -.
DR   Proteomes; UP000002428; Chromosome K.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:EnsemblFungi.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0061415; P:negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source; IEA:EnsemblFungi.
DR   GO; GO:0061414; P:positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source; IEA:EnsemblFungi.
DR   CDD; cd00067; GAL4; 1.
DR   CDD; cd00130; PAS; 1.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SMART; SM00091; PAS; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS50112; PAS; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..596
FT                   /note="Transcription activator of gluconeogenesis ERT1"
FT                   /id="PRO_0000406459"
FT   DOMAIN          476..548
FT                   /note="PAS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT   DNA_BIND        68..96
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          209..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   596 AA;  68233 MW;  468D75FA122CA0DF CRC64;
     MNNATSYYRT SGEQDGKLTS TLPSGSTSNT NVRYSSNDNS DGTIQSDTSI SQTSHTVKKK
     RKNTNVACVN CSRNHSSCEQ KRPCSRCIKK GIANTCVDAP RKKKKYLEGI DTLPIRVGSN
     TPHYGTPLQI GYHSASFIDN QQYGQTPRHS IGDFNDIYPT SYKSYPENRY NVRNDQAHRF
     QSYAANSEYS VLSTIVRQNS LNNNNHQIIH RNRDTITSPG PIQSYNSISS ELNSPSSSSP
     KSNGLTRNNS MSPNAKNFDL NSQQHDTYAH KPPQPYPSSK SHIYSILLGD YGKEILQSQV
     NLYANHFPLV PFLSVDGTLD FKRIYPSDPS KTENTDSFFN TKINQYYVNN EFLTFPELKY
     KIDSGKVEKV TDTENYAVSV SVECPPPDGS RLYNNVEWDH SLKYGTPVEI YKLINEPFSH
     TPGFRHLLQY LRKRFSQKDL VSMCQNMAYF RPIFIACSIT LTEEDMIFME QCYQRTLLQY
     VKFIQEIGTP TVVWRRNGQI SYVNDEFEIL SGWKREELLD KMSFIVEIID DESVREYFKT
     FARIAYNNIK GSEQMDVCRL LTPIRNQVIE CKCIWTLKRD MSGLPLMILG NFLPVL