ID   ERT1_COPC7              Reviewed;         541 AA.
AC   A8N767;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Transcription activator of gluconeogenesis ERT1;
GN   Name=ERT1; ORFNames=CC1G_03210;
OS   Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
OS   (Inky cap fungus) (Hormographiella aspergillata).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Psathyrellaceae; Coprinopsis.
OX   NCBI_TaxID=240176;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003;
RX   PubMed=20547848; DOI=10.1073/pnas.1003391107;
RA   Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W., Borodovsky M.,
RA   Burns C., Canbaeck B., Casselton L.A., Cheng C.K., Deng J., Dietrich F.S.,
RA   Fargo D.C., Farman M.L., Gathman A.C., Goldberg J., Guigo R., Hoegger P.J.,
RA   Hooker J.B., Huggins A., James T.Y., Kamada T., Kilaru S., Kodira C.,
RA   Kuees U., Kupfer D., Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.-J.,
RA   Mackey A.J., Manning G., Martin F., Muraguchi H., Natvig D.O.,
RA   Palmerini H., Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M.,
RA   Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q.,
RA   Zolan M.E., Pukkila P.J.;
RT   "Insights into evolution of multicellular fungi from the assembled
RT   chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; AACS02000003; EAU91042.1; -; Genomic_DNA.
DR   RefSeq; XP_001830673.1; XM_001830621.2.
DR   AlphaFoldDB; A8N767; -.
DR   SMR; A8N767; -.
DR   STRING; 5346.XP_001830673.1; -.
DR   EnsemblFungi; EAU91042; EAU91042; CC1G_03210.
DR   GeneID; 6007117; -.
DR   KEGG; cci:CC1G_03210; -.
DR   VEuPathDB; FungiDB:CC1G_03210; -.
DR   eggNOG; ENOG502R1M5; Eukaryota.
DR   HOGENOM; CLU_010748_2_1_1; -.
DR   InParanoid; A8N767; -.
DR   OMA; VMTTCKL; -.
DR   OrthoDB; 681770at2759; -.
DR   Proteomes; UP000001861; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..541
FT                   /note="Transcription activator of gluconeogenesis ERT1"
FT                   /id="PRO_0000406460"
FT   DOMAIN          423..495
FT                   /note="PAS"
FT   DNA_BIND        77..105
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          126..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          196..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          286..315
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..42
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        199..214
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   541 AA;  59856 MW;  5CD264CA8E635620 CRC64;
     MFAVAPRPAP LAPAQAGPST SPQQTLKKSS SQSSITSAPT KRRRTVTPED SPQDSAPSQP
     QKKAREGPKK KKANRACFHC QKAHLTCDDS RPCQRCIKRG IANNCREGHR KKAKYLLDDD
     ELEALKRSKE GAKGKAPEPQ PQPQLHQPVV ATMPISEPVP QSEQLLTTAF DPTTFAFGSE
     AANLEYSILS AILGNPSPPD SASSPPPPPS QSHYSWPSDP LDFTASPRLG TSFTSSYTDA
     QQLSISSDSV LSTSPSAQFL NYSYSQQQRS DEGSDLPYSQ YSAQAPLHPL QPRYPLDQRP
     RSPPTSTVGE KVSTDVASRG LLTPPLSNAS PSSIASVPPG VAEIPQPKSA VSHLQSINDR
     VTKPYDYTEG YHFLMKHLPT RFEKNDILRV VRALAIFRPS LIALQMPLSL DDEIFVEKCF
     QRSLLELGKL ISYSGTPTVV WRRTGEICLV APEFCMLTEW PMEELVGRRK YIYELFENQS
     VVEYWENFAS HAFENTTRSV YSHCVLLKPD GTPVPATFCF SIRRDLFDLP SMVIGQWLPL
     L