ID   ERT1_DEBHA              Reviewed;         571 AA.
AC   Q6BY37;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   04-NOV-2008, sequence version 2.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Transcription activator of gluconeogenesis ERT1;
GN   Name=ERT1; OrderedLocusNames=DEHA2A12738g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; CR382133; CAG84859.2; -; Genomic_DNA.
DR   RefSeq; XP_456882.2; XM_456882.1.
DR   AlphaFoldDB; Q6BY37; -.
DR   STRING; 4959.XP_456882.2; -.
DR   EnsemblFungi; CAG84859; CAG84859; DEHA2A12738g.
DR   GeneID; 2899379; -.
DR   KEGG; dha:DEHA2A12738g; -.
DR   VEuPathDB; FungiDB:DEHA2A12738g; -.
DR   eggNOG; ENOG502R1M5; Eukaryota.
DR   HOGENOM; CLU_010748_2_3_1; -.
DR   InParanoid; Q6BY37; -.
DR   OMA; VMTTCKL; -.
DR   OrthoDB; 681770at2759; -.
DR   Proteomes; UP000000599; Chromosome A.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..571
FT                   /note="Transcription activator of gluconeogenesis ERT1"
FT                   /id="PRO_0000406461"
FT   DOMAIN          403..475
FT                   /note="PAS"
FT   DNA_BIND        20..48
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          76..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          141..187
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          216..282
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..110
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   571 AA;  64335 MW;  2EA630654BFF3ECA CRC64;
     MSEIKNEPMS NSDSVASSNS AKMRRKKTNR ACNHCHKAHM TCDTNRPCQR CLQRGLESSC
     QDAPRKRKKY LADVPPNVLS RHDGLSQSPP YEMGKNDTIN YQSGPFQERP PSSEFNPPMP
     TANTDNDINQ DFGAFGVYPN SHLFPSNTNQ TNQDAGADMS HSQGQSKPPI NQHMHQQGLP
     SYNKPRRTNF LSSAADLEYS TLSSILQDNF VHVNNNTSAE GTPNSLNLSP SVLPNNAPNT
     NITDSRNTTS SNSLNNYGQQ NKPMNYTSGS SHASSPNDSI FNSKQMSSIN GINKNKYYYS
     SKYPKCDESI NQYFLGPTGS DHELIYPDVI TAIEEMKALD PAVYHERNSK SSLSFTIGII
     PESNEYTKGR KPQENKETFK EPDEIYAKVN KPFSYTPGYH SLIAYLRKRF PKEMLVKMAE
     SIAAYRPSFI ACTNSLKESD LIFMEQCFQR TLLTYDNFIR VSGTPTIVWR RTGEIAYVGN
     EFCVLTGWKK EDLLLNTKKF IVELLDDKSV VEYFQLFSKI AFGDFLGATM TECTLLTPKK
     DVKIRTGCMW TLKRDVFGIP MMIIGNFLPI I