ID   ERT1_KLULA              Reviewed;         507 AA.
AC   Q6CKI5;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Transcription activator of gluconeogenesis ERT1;
GN   Name=ERT1; OrderedLocusNames=KLLA0F10417g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98262.1; -; Genomic_DNA.
DR   RefSeq; XP_455554.1; XM_455554.1.
DR   AlphaFoldDB; Q6CKI5; -.
DR   STRING; 28985.XP_455554.1; -.
DR   EnsemblFungi; CAG98262; CAG98262; KLLA0_F10417g.
DR   GeneID; 2895893; -.
DR   KEGG; kla:KLLA0_F10417g; -.
DR   eggNOG; ENOG502R1M5; Eukaryota.
DR   HOGENOM; CLU_010748_2_3_1; -.
DR   InParanoid; Q6CKI5; -.
DR   OMA; VMTTCKL; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:EnsemblFungi.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0061415; P:negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source; IEA:EnsemblFungi.
DR   GO; GO:0061414; P:positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source; IEA:EnsemblFungi.
DR   CDD; cd00067; GAL4; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50112; PAS; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..507
FT                   /note="Transcription activator of gluconeogenesis ERT1"
FT                   /id="PRO_0000406462"
FT   DOMAIN          379..451
FT                   /note="PAS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT   DNA_BIND        13..41
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          95..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..121
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   507 AA;  57910 MW;  16129D1909280F54 CRC64;
     MSVKRNKKVS VACVHCAKSH VTCDDNRPCT RCIRKGLEES CIDAPRKKVK YLRDVPEDQL
     PSVLRSTKQV PPVNAVKLKM EPGILPNIPL DYDGGTIRQS APANNGKNNP ETQQTLSNGQ
     ITHRPKFLSS AADLEYSILS DIIHGDSLFN KIPVNFLYSN PTEKTPSPIN QGSLNGQQDL
     HFSLQLRSKP MNQIRGNTRA IYSNLLGPVS HEILQSEFNL YTNHFPLQPQ ESLDGTLDFK
     RMTIGTLSPH LTKFDKTINQ YYLNFANTFP EIYDSRKIPN LSYALEVEPP EYREIPHDTE
     IPHTLRFTTP SEIYSLVQTA FPSTTGFHAL LRYLKRRFDK NQLVEMCRCL AELRPIFIAS
     TIDLTDEDMI FMEKSHQRTL LEYEKFISQV GTPTCVWRRN GQISYVNDEF SLLTGWNRLE
     LLNKMTFIVE LMDGDTVMEY FQTFTRVAYQ GFRGAETMRI CNLLTPIKGS VIKCCCLWTL
     KRDAFGLPMM IIGNFMPILT LPEDVGF