ID   ERT1_KOMPG              Reviewed;         481 AA.
AC   C4R1K8;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Transcription activator of gluconeogenesis ERT1;
GN   Name=ERT1; OrderedLocusNames=PAS_chr2-1_0732;
OS   Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=644223;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS115 / ATCC 20864;
RX   PubMed=19465926; DOI=10.1038/nbt.1544;
RA   De Schutter K., Lin Y.-C., Tiels P., Van Hecke A., Glinka S.,
RA   Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT   "Genome sequence of the recombinant protein production host Pichia
RT   pastoris.";
RL   Nat. Biotechnol. 27:561-566(2009).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; FN392320; CAY69382.1; -; Genomic_DNA.
DR   RefSeq; XP_002491662.1; XM_002491617.1.
DR   AlphaFoldDB; C4R1K8; -.
DR   SMR; C4R1K8; -.
DR   STRING; 644223.C4R1K8; -.
DR   EnsemblFungi; CAY69382; CAY69382; PAS_chr2-1_0732.
DR   GeneID; 8198350; -.
DR   KEGG; ppa:PAS_chr2-1_0732; -.
DR   eggNOG; ENOG502R1M5; Eukaryota.
DR   HOGENOM; CLU_010748_2_3_1; -.
DR   InParanoid; C4R1K8; -.
DR   OMA; DEMSANG; -.
DR   Proteomes; UP000000314; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..481
FT                   /note="Transcription activator of gluconeogenesis ERT1"
FT                   /id="PRO_0000406466"
FT   DOMAIN          362..434
FT                   /note="PAS"
FT   DNA_BIND        29..57
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          193..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   481 AA;  54180 MW;  51C1C7354EF7C61F CRC64;
     MVDKATTERK LKAPLSGRKR VPKKTAHACN YCHQAHMTCD DSRPCKRCIQ RNLADSCRDA
     PRKKKKYLMD IPDEVADPSA QQLTPDAVMG PSPSTMTLSQ SNAFMSSAAD LEYSILGNII
     HQDSGQFVGT DGTVISPSIS TSDDNSHITP LAHYNGAIQG PAVYTKSPLN FEGSYAMTPI
     QRRTDINEIQ PDLLRSEPSS NDTFGPTLHG EEPSCDSSTN QYFIGPSFSS DGRAQTLTFP
     YVVSQIERTK RYNPKEFRRR NKKSAISFSV GLMTDESSDK RDESITGLVY HEPSEIYSKI
     KRPYSYPQYY HSLILYLRKR FDKESLVAMS KAMAEYRPSF IAGTMNLKED DLIFTEQCFQ
     RTLLEYDNYI SISGTPTVVW RRTSQLAYVG SEFCVLTGWS KEQLLGRSTF IVEILDDKSV
     LDYFELFSKI AFGDFRGATM TECTLLTPDG KKIRTSSIWT LKRDVFGIPM MVIANFLPIL
     T