ID   AGRB_STAAT              Reviewed;         189 AA.
AC   A8Z4U0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Accessory gene regulator protein B {ECO:0000255|HAMAP-Rule:MF_00784};
DE            EC=3.4.-.- {ECO:0000255|HAMAP-Rule:MF_00784};
GN   Name=agrB {ECO:0000255|HAMAP-Rule:MF_00784};
GN   OrderedLocusNames=USA300HOU_2032;
OS   Staphylococcus aureus (strain USA300 / TCH1516).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=451516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300 / TCH1516;
RX   PubMed=17986343; DOI=10.1186/1471-2180-7-99;
RA   Highlander S.K., Hulten K.G., Qin X., Jiang H., Yerrapragada S.,
RA   Mason E.O. Jr., Shang Y., Williams T.M., Fortunov R.M., Liu Y., Igboeli O.,
RA   Petrosino J., Tirumalai M., Uzman A., Fox G.E., Cardenas A.M., Muzny D.M.,
RA   Hemphill L., Ding Y., Dugan S., Blyth P.R., Buhay C.J., Dinh H.H.,
RA   Hawes A.C., Holder M., Kovar C.L., Lee S.L., Liu W., Nazareth L.V.,
RA   Wang Q., Zhou J., Kaplan S.L., Weinstock G.M.;
RT   "Subtle genetic changes enhance virulence of methicillin resistant and
RT   sensitive Staphylococcus aureus.";
RL   BMC Microbiol. 7:99-99(2007).
CC   -!- FUNCTION: Essential for the production of a quorum sensing system
CC       signal molecule, the autoinducing peptide (AIP). This quorum sensing
CC       system is responsible for the regulation of the expression of virulence
CC       factor genes. Involved in the proteolytic processing of AgrD, the
CC       precursor of AIP. {ECO:0000255|HAMAP-Rule:MF_00784}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00784};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00784}.
CC   -!- SIMILARITY: Belongs to the AgrB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00784}.
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DR   EMBL; CP000730; ABX30029.1; -; Genomic_DNA.
DR   RefSeq; WP_001105707.1; NC_010079.1.
DR   AlphaFoldDB; A8Z4U0; -.
DR   MEROPS; C75.001; -.
DR   KEGG; sax:USA300HOU_2032; -.
DR   HOGENOM; CLU_098969_2_2_9; -.
DR   OMA; MKFAIVY; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00784; AgrB; 1.
DR   InterPro; IPR006741; AgrB.
DR   Pfam; PF04647; AgrB; 1.
DR   SMART; SM00793; AgrB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Membrane; Protease; Quorum sensing;
KW   Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..189
FT                   /note="Accessory gene regulator protein B"
FT                   /id="PRO_1000083588"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT   TRANSMEM        81..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
SQ   SEQUENCE   189 AA;  21930 MW;  3A419DA6F3206895 CRC64;
     MNYFDNKIDQ FATYLQKRNN LDHIQFLQVR LGMQVLAKNI GKLIVMYTIA YILNIFLFTL
     ITNLTFYLIR RHAHGAHAPS SFWCYVESII LFILLPLVIV NFHINFLIMI ILTVISLGVI
     SVYAPAATKK KPIPVRLIKR KKYYAIIVSL TLFIITLIIK EPFAQFIQLG IIIEAITLLP
     IFFIKEDLK