ID   ERT1_PICGU              Reviewed;         468 AA.
AC   A5DF43;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Transcription activator of gluconeogenesis ERT1;
GN   Name=ERT1; ORFNames=PGUG_01894;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH408156; EDK37796.2; -; Genomic_DNA.
DR   RefSeq; XP_001486223.1; XM_001486173.1.
DR   AlphaFoldDB; A5DF43; -.
DR   STRING; 4929.XP_001486223.1; -.
DR   EnsemblFungi; EDK37796; EDK37796; PGUG_01894.
DR   GeneID; 5128027; -.
DR   KEGG; pgu:PGUG_01894; -.
DR   VEuPathDB; FungiDB:PGUG_01894; -.
DR   eggNOG; ENOG502R1M5; Eukaryota.
DR   HOGENOM; CLU_010748_2_3_1; -.
DR   InParanoid; A5DF43; -.
DR   OMA; VMTTCKL; -.
DR   OrthoDB; 681770at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..468
FT                   /note="Transcription activator of gluconeogenesis ERT1"
FT                   /id="PRO_0000406465"
FT   DOMAIN          349..422
FT                   /note="PAS"
FT   DNA_BIND        63..91
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
SQ   SEQUENCE   468 AA;  52526 MW;  0127120CDBC7966B CRC64;
     MSAPAEAGQR PVSTPVFRFK LNKVSAYGAL NSLIVFRIIF LLKNPLFLMF TNKQKRKKTI
     RACTHCHRAH LLCDENRPCA RCVQKGLQAT CQDAPRKRKK YLLDVPPDSM QKQRYQSPEI
     KPEYPMNTLL PLPGQQIQRK SNFLSSAADM EYSTLSNILS ENVHPFPNPS TSNEGTPNSI
     TLSPALSPGT GGRTSTTYTA PTDIACDNAL NQYVLGPTTT GISLYPDVVM AIETLKNTHP
     SVIHERNTRS TVSYAMGFMP DGNPHVSLPG GDYASVYAEP EDIYAKVRKP YSYTPGYHAL
     IAYLRSRFPK QMLVKMAESM AAYRPSFIAC TNALKEDDLI FMEQCFQRTL LTYDNFIKLS
     GTPTIVWRRT GEIAYVGDEF CVLTGWPKAE LITQKKRLIV ELLDDKSVVE YFELFSKIAF
     GDFLGATMTE CTLLTSKPDV KIRTSCIWTL KRDVFGIPMM IIGNFLPI