ID   ERT1_PICST              Reviewed;         565 AA.
AC   A3LQV7;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Transcription activator of gluconeogenesis ERT1;
GN   Name=ERT1; Synonyms=FST9; ORFNames=PICST_77215;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; CP000497; ABN65276.2; -; Genomic_DNA.
DR   RefSeq; XP_001383305.2; XM_001383268.1.
DR   AlphaFoldDB; A3LQV7; -.
DR   SMR; A3LQV7; -.
DR   STRING; 4924.XP_001383305.2; -.
DR   EnsemblFungi; ABN65276; ABN65276; PICST_77215.
DR   GeneID; 4837808; -.
DR   KEGG; pic:PICST_77215; -.
DR   eggNOG; ENOG502R1M5; Eukaryota.
DR   HOGENOM; CLU_010748_2_3_1; -.
DR   InParanoid; A3LQV7; -.
DR   OMA; VMTTCKL; -.
DR   OrthoDB; 681770at2759; -.
DR   Proteomes; UP000002258; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50112; PAS; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..565
FT                   /note="Transcription activator of gluconeogenesis ERT1"
FT                   /id="PRO_0000406467"
FT   DOMAIN          445..518
FT                   /note="PAS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT   DNA_BIND        30..58
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          139..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          227..279
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   565 AA;  63637 MW;  1FE850D8C7551FF6 CRC64;
     MSSDESERTV SVKQEDDSLR PKRKKTNRAC NHCHKAHMTC DSGRPCKRCI QRGLDKTCED
     ARRKRKKYLA DVPNTALLPN RLQQAETYDG TNASPTESGR SIMYQATTFQ HSSTVPISYT
     NSINDDIYSL GFSKSHNSFL PRNQNQTQPL ARSQSTFSQK QSTLPQTHSN LSSSRRTNFL
     SSAADLEYST LSSILQDNFM HGNHSTSNEG TPNSITLSPA LSPHALTTTV SSNTNTGTAT
     RNMTTPDDLN YTSKRNKPYV AGSSQTPSPQ DQLSNGSMEA KARISNASAS IYDHQRYPKC
     DESINQYFLG PTESDQVSMF PDVITAIETM KASDPSVFYE RNSKSALSFT IGIVPDDNHY
     TKNHDSVENE SFYKEPEEIY AKVKKPFSYT PGYHSLIAYL RKRFNKPMLV KMAESMAAYR
     PSFIACTNSL KEGDLIFMEQ CFQRTLLTYD NFIRVSGTPT IVWRRTGEIA YVGNEFCILT
     GWSKEELLGK QRKFIVELLD DKSVLEYFQL FSRIAFGDFL GATMTECTLL TPKTDVKIRT
     GCMWTLKRDV FGIPMMIVGN FLPIL