ID   ERT1_SCHCM              Reviewed;         560 AA.
AC   D8Q8R5;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Transcription activator of gluconeogenesis ERT1;
GN   Name=ERT1; ORFNames=SCHCODRAFT_257622;
OS   Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX   NCBI_TaxID=578458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H4-8 / FGSC 9210;
RX   PubMed=20622885; DOI=10.1038/nbt.1643;
RA   Ohm R.A., de Jong J.F., Lugones L.G., Aerts A., Kothe E., Stajich J.E.,
RA   de Vries R.P., Record E., Levasseur A., Baker S.E., Bartholomew K.A.,
RA   Coutinho P.M., Erdmann S., Fowler T.J., Gathman A.C., Lombard V.,
RA   Henrissat B., Knabe N., Kuees U., Lilly W.W., Lindquist E., Lucas S.,
RA   Magnuson J.K., Piumi F., Raudaskoski M., Salamov A., Schmutz J.,
RA   Schwarze F.W.M.R., vanKuyk P.A., Horton J.S., Grigoriev I.V.,
RA   Woesten H.A.B.;
RT   "Genome sequence of the model mushroom Schizophyllum commune.";
RL   Nat. Biotechnol. 28:957-963(2010).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; GL377308; EFI95523.1; -; Genomic_DNA.
DR   RefSeq; XP_003030426.1; XM_003030380.1.
DR   AlphaFoldDB; D8Q8R5; -.
DR   SMR; D8Q8R5; -.
DR   STRING; 578458.D8Q8R5; -.
DR   EnsemblFungi; EFI95523; EFI95523; SCHCODRAFT_257622.
DR   GeneID; 9591431; -.
DR   KEGG; scm:SCHCODRAFT_257622; -.
DR   eggNOG; ENOG502R1M5; Eukaryota.
DR   HOGENOM; CLU_010748_1_0_1; -.
DR   InParanoid; D8Q8R5; -.
DR   OMA; VMTTCKL; -.
DR   OrthoDB; 681770at2759; -.
DR   Proteomes; UP000007431; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..560
FT                   /note="Transcription activator of gluconeogenesis ERT1"
FT                   /id="PRO_0000406469"
FT   DOMAIN          442..515
FT                   /note="PAS"
FT   DNA_BIND        90..118
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          28..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          139..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          301..331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          339..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..77
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        139..158
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        343..358
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   560 AA;  61867 MW;  2492AE9BA5A847AE CRC64;
     MSTVHVVAPV AVHSVPPAQL LPQTATPPAY AQTLGGEAAS TLAQKKKSPP LSANKRKRSE
     TADDSTDQES NTPSRKSRDG PKKKKANRAC FHCQKAHLTC DDSRPCQRCI KRGIANNCTE
     GHRKKAKYLL DDEELEELKR KQNTVPSRKS EPRTEKPKPS EPPAQTAQAP AAPLPRPSLQ
     AQAQPVPISA PAPIPASTSE PFAPNDPMFN LTFDSNFPFG SEAANLEYTI LSAILGNPSP
     PDTTSPPPQP YPWPSDTLSF NSPQLDSFSS FPENVLPVIS ADNLLSSTGS LNYLQARTAK
     QQSTADPADL QCGDDASKYT RDGRCSSPPS FYMDKESAAR TLLSPPPTDS PGSATSTVPL
     NEVAPFPRPG SHLQSITDRV KAPYDYTEGY HFLMKHLTTR FEKNDILRVV RALAIFRPSL
     IALQMPLSWD DEVFVERCFQ RSLLELDKLI SYSGTPTVVW RRTGEICLVA PEFCMLTEWS
     MEELMGQKKY IYELFENQSV VEYWENFAEH AFENTTQSVY SHCVLLKPSG APVPATFCFS
     IRRDLFDLPS AVIGQWLPLL