ID   ERT1_ZYGRC              Reviewed;         512 AA.
AC   C5E1J9;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Transcription activator of gluconeogenesis;
GN   Name=ERT1; OrderedLocusNames=ZYRO0G21582g;
OS   Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568
OS   / NRRL Y-229) (Candida mogii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX   NCBI_TaxID=559307;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2623 / CBS 732 / BCRC 21506 / NBRC 1130 / NCYC 568 / NRRL
RC   Y-229;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; CU928179; CAR29983.1; -; Genomic_DNA.
DR   RefSeq; XP_002498916.1; XM_002498871.1.
DR   AlphaFoldDB; C5E1J9; -.
DR   SMR; C5E1J9; -.
DR   STRING; 559307.C5E1J9; -.
DR   EnsemblFungi; CAR29983; CAR29983; ZYRO0G21582g.
DR   GeneID; 8206752; -.
DR   KEGG; zro:ZYRO0G21582g; -.
DR   HOGENOM; CLU_010748_2_3_1; -.
DR   InParanoid; C5E1J9; -.
DR   Proteomes; UP000008536; Chromosome G.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00130; PAS; 1.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SMART; SM00091; PAS; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS50112; PAS; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..512
FT                   /note="Transcription activator of gluconeogenesis"
FT                   /id="PRO_0000406477"
FT   DOMAIN          391..463
FT                   /note="PAS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT   DNA_BIND        41..69
FT                   /note="Zn(2)-C6 fungal-type"
FT   REGION          95..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..116
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   512 AA;  57475 MW;  2AF91A1F8D049842 CRC64;
     MGGGSGPSDE FANILPHFSQ VDSSVPVSSG KKSRRNTHVA CVNCSKWHVS CEAKRPCHRC
     VVKGLGSTCV DAPRKKSKYL AGIPDASLIR SVHRDNGSQA NNSSPDNAGV SHHQEQQNFR
     DPQHIVHKSK FLSNAADSEY SILSHIINQD TLVNKIPIDL LYSGKPNDND AEAAAAVAAK
     EAANVDLSSP KVDVGPSNTA MSSTDVYSML LGPNSREIVA SRIDLFQNHF PLTPVESQYH
     SLSFKRLPTQ DRSGSPKFNA SINQYYLNKE ISMLPEVINA AMRQQRSVGD KSVSFALECV
     SPDAYQLSGN SEWRHSLRYS TSMEIYQLIN EPFSHTTGFH HLYTYLRKRF NRKDLIEMSG
     CLAEFRPIFI ACTASLTEQD MIFMEQCYQR TLLEYAKFIA QIGTPTCVWR RNGQISYVNE
     EFEILSGWNK EELLNKMTFI VEIMDDESVR DYFKTFAKVA YKDFRGSERM KTCNLLTPTR
     GQIIPCCCMW TLKRDVSGLP LMILGNFMPI IA