ERV14_SCHPO
ID ERV14_SCHPO Reviewed; 137 AA.
AC Q9P6K6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 2.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=ER-derived vesicles protein erv14;
GN Name=erv14; ORFNames=SPAC30C2.05;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2] {ECO:0000305}
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Regulates export of the secretory proteins from the
CC endoplasmic reticulum in COPII-coated vesicles.
CC {ECO:0000250|UniProtKB:P53173}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000269|PubMed:16823372}. Membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}. Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:P53173}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P53173}. Note=Resides in the endoplasmic and
CC Golgi compartments, and then packaged into endoplasmic reticulum
CC derived vesicles. {ECO:0000250|UniProtKB:P53173,
CC ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the cornichon family. {ECO:0000255}.
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DR EMBL; CU329670; CAB90792.2; -; Genomic_DNA.
DR RefSeq; NP_594657.2; NM_001020086.3.
DR AlphaFoldDB; Q9P6K6; -.
DR SMR; Q9P6K6; -.
DR BioGRID; 279514; 3.
DR STRING; 4896.SPAC30C2.05.1; -.
DR PaxDb; Q9P6K6; -.
DR EnsemblFungi; SPAC30C2.05.1; SPAC30C2.05.1:pep; SPAC30C2.05.
DR GeneID; 2543081; -.
DR KEGG; spo:SPAC30C2.05; -.
DR PomBase; SPAC30C2.05; erv14.
DR VEuPathDB; FungiDB:SPAC30C2.05; -.
DR eggNOG; KOG2729; Eukaryota.
DR HOGENOM; CLU_112942_0_0_1; -.
DR InParanoid; Q9P6K6; -.
DR OMA; WIAFLLN; -.
DR PhylomeDB; Q9P6K6; -.
DR PRO; PR:Q9P6K6; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; ISO:PomBase.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:PomBase.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:PomBase.
DR GO; GO:0006886; P:intracellular protein transport; IC:PomBase.
DR InterPro; IPR003377; Cornichon.
DR InterPro; IPR033466; Cornichon_conserved.
DR Pfam; PF03311; Cornichon; 1.
DR SMART; SM01398; Cornichon; 1.
DR PROSITE; PS01340; CORNICHON; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Golgi apparatus; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..137
FT /note="ER-derived vesicles protein erv14"
FT /id="PRO_0000315909"
FT TOPO_DOM 1..9
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31..62
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 84..114
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..137
FT /note="Extracellular"
FT /evidence="ECO:0000255"
SQ SEQUENCE 137 AA; 15990 MW; A3D4D9D5A078B8E8 CRC64;
MMSFGSFVYI ACLLLNGANM LLQIFCVIMF SDLEMDYINP IDLCNKLNDL VMPEIISHTL
VTLLLLLGKK WLLFLANLPL LVFHANQVIH KTHILDATEI FRQLGRHKRD NFIKVTFYLI
MFFTLLYCMV MSLIQEE
