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AGRB_STAAW
ID   AGRB_STAAW              Reviewed;         187 AA.
AC   Q8NVK5;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Accessory gene regulator protein B {ECO:0000255|HAMAP-Rule:MF_00784};
DE            EC=3.4.-.- {ECO:0000255|HAMAP-Rule:MF_00784};
GN   Name=agrB {ECO:0000255|HAMAP-Rule:MF_00784}; OrderedLocusNames=MW1960;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
CC   -!- FUNCTION: Essential for the production of a quorum sensing system
CC       signal molecule, the autoinducing peptide (AIP). This quorum sensing
CC       system is responsible for the regulation of the expression of virulence
CC       factor genes. Involved in the proteolytic processing of AgrD, the
CC       precursor of AIP. {ECO:0000255|HAMAP-Rule:MF_00784}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00784};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00784}.
CC   -!- SIMILARITY: Belongs to the AgrB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00784}.
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DR   EMBL; BA000033; BAB95825.1; -; Genomic_DNA.
DR   RefSeq; WP_001105705.1; NC_003923.1.
DR   AlphaFoldDB; Q8NVK5; -.
DR   MEROPS; C75.001; -.
DR   TCDB; 9.B.46.1.1; the staphylococcus aureus putative quorum sensing peptide exporter, agrb (agrb) family.
DR   EnsemblBacteria; BAB95825; BAB95825; BAB95825.
DR   KEGG; sam:MW1960; -.
DR   HOGENOM; CLU_098969_2_2_9; -.
DR   OMA; MKFAIVY; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00784; AgrB; 1.
DR   InterPro; IPR006741; AgrB.
DR   Pfam; PF04647; AgrB; 1.
DR   SMART; SM00793; AgrB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Membrane; Protease; Quorum sensing;
KW   Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..187
FT                   /note="Accessory gene regulator protein B"
FT                   /id="PRO_0000168125"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
SQ   SEQUENCE   187 AA;  21801 MW;  FF10186C3ED200F8 CRC64;
     MNYFDNKIDQ FATYLQKRNN LDHIQFLQVR LGMQVLAKNI GKLIVMYTIA YILNIFIFTL
     ITNISFYLIR RYAHGAHAPS SFWCYIESIT LFIVLPLLVL HFHINETLMM FLALISVGVV
     IKYAPAATKK KPIPARLVKQ KRYFSIIIST ILFIITLFVK EPYTQFIQLG IIIQAITLLP
     IYYSKED
 
 
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