ID   AGRB_STACT              Reviewed;         191 AA.
AC   B9DML4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Accessory gene regulator protein B {ECO:0000255|HAMAP-Rule:MF_00784};
DE            EC=3.4.-.- {ECO:0000255|HAMAP-Rule:MF_00784};
GN   Name=agrB {ECO:0000255|HAMAP-Rule:MF_00784}; OrderedLocusNames=Sca_1545;
OS   Staphylococcus carnosus (strain TM300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=396513;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TM300;
RX   PubMed=19060169; DOI=10.1128/aem.01982-08;
RA   Rosenstein R., Nerz C., Biswas L., Resch A., Raddatz G., Schuster S.C.,
RA   Goetz F.;
RT   "Genome analysis of the meat starter culture bacterium Staphylococcus
RT   carnosus TM300.";
RL   Appl. Environ. Microbiol. 75:811-822(2009).
CC   -!- FUNCTION: Essential for the production of a quorum sensing system
CC       signal molecule, the autoinducing peptide (AIP). This quorum sensing
CC       system is responsible for the regulation of the expression of virulence
CC       factor genes. Involved in the proteolytic processing of AgrD, the
CC       precursor of AIP. {ECO:0000255|HAMAP-Rule:MF_00784}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00784};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00784}.
CC   -!- SIMILARITY: Belongs to the AgrB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00784}.
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DR   EMBL; AM295250; CAL28450.1; -; Genomic_DNA.
DR   RefSeq; WP_015900790.1; NC_012121.1.
DR   AlphaFoldDB; B9DML4; -.
DR   STRING; 396513.SCA_1545; -.
DR   MEROPS; C75.001; -.
DR   PRIDE; B9DML4; -.
DR   GeneID; 60544746; -.
DR   KEGG; sca:SCA_1545; -.
DR   eggNOG; COG4512; Bacteria.
DR   HOGENOM; CLU_098969_2_2_9; -.
DR   OMA; MKFAIVY; -.
DR   OrthoDB; 1320951at2; -.
DR   BioCyc; SCAR396513:SCA_RS07835-MON; -.
DR   Proteomes; UP000000444; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00784; AgrB; 1.
DR   InterPro; IPR006741; AgrB.
DR   Pfam; PF04647; AgrB; 1.
DR   SMART; SM00793; AgrB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Membrane; Protease; Quorum sensing;
KW   Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..191
FT                   /note="Accessory gene regulator protein B"
FT                   /id="PRO_1000148474"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
SQ   SEQUENCE   191 AA;  21899 MW;  0D8C6D180A88B5A4 CRC64;
     MQKVLERKID AWAQALQKRN NLDRIAYLKI KLGLEVFFNN LFKTIVVYGL ALLFHVFLYT
     LTVHLSYFAI RHYAHGAHAK STFACYIESI ILFVILPWIL IKVDIPQIFM IVLAAVAFIL
     ICLYSPAITR KQPIPNHMRK KKKITAIFVA GILLIISFFI KQPFNELVQL GIVLIGAAQL
     PIFFPKQTKE G