ERVV1_HUMAN
ID ERVV1_HUMAN Reviewed; 477 AA.
AC B6SEH8;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Endogenous retrovirus group V member 1 Env polyprotein;
DE AltName: Full=HERV-V_19q13.41 provirus ancestral Env polyprotein 1;
DE Flags: Precursor;
GN Name=ERVV-1; Synonyms=ENVV1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX PubMed=18826608; DOI=10.1186/1471-2148-8-266;
RA Kjeldbjerg A.L., Villesen P., Aagaard L., Pedersen F.S.;
RT "Gene conversion and purifying selection of a placenta-specific ERV-V
RT envelope gene during simian evolution.";
RL BMC Evol. Biol. 8:266-266(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in placenta.
CC {ECO:0000269|PubMed:18826608}.
CC -!- SIMILARITY: Belongs to the gamma type-C retroviral envelope protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EU853142; ACI62853.1; -; Genomic_DNA.
DR EMBL; AC010328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS59419.1; -.
DR RefSeq; NP_689686.2; NM_152473.2.
DR AlphaFoldDB; B6SEH8; -.
DR SMR; B6SEH8; -.
DR BioGRID; 127071; 1.
DR STRING; 9606.ENSP00000473153; -.
DR GlyGen; B6SEH8; 1 site.
DR iPTMnet; B6SEH8; -.
DR PhosphoSitePlus; B6SEH8; -.
DR BioMuta; ERVV-1; -.
DR PaxDb; B6SEH8; -.
DR PeptideAtlas; B6SEH8; -.
DR PRIDE; B6SEH8; -.
DR DNASU; 147664; -.
DR Ensembl; ENST00000602168.2; ENSP00000473153.1; ENSG00000269526.2.
DR GeneID; 147664; -.
DR KEGG; hsa:147664; -.
DR MANE-Select; ENST00000602168.2; ENSP00000473153.1; NM_152473.3; NP_689686.2.
DR CTD; 147664; -.
DR GeneCards; ERVV-1; -.
DR HGNC; HGNC:26501; ERVV-1.
DR HPA; ENSG00000269526; Tissue enriched (placenta).
DR neXtProt; NX_B6SEH8; -.
DR VEuPathDB; HostDB:ENSG00000269526; -.
DR eggNOG; ENOG502SD08; Eukaryota.
DR GeneTree; ENSGT00940000164101; -.
DR HOGENOM; CLU_045261_0_0_1; -.
DR InParanoid; B6SEH8; -.
DR OMA; KCDAQNP; -.
DR OrthoDB; 389221at2759; -.
DR PhylomeDB; B6SEH8; -.
DR PathwayCommons; B6SEH8; -.
DR SignaLink; B6SEH8; -.
DR BioGRID-ORCS; 147664; 19 hits in 979 CRISPR screens.
DR ChiTaRS; ERVV-1; human.
DR GenomeRNAi; 147664; -.
DR Pharos; B6SEH8; Tdark.
DR PRO; PR:B6SEH8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; B6SEH8; protein.
DR Bgee; ENSG00000269526; Expressed in placenta and 24 other tissues.
DR ExpressionAtlas; B6SEH8; baseline and differential.
DR Genevisible; B6SEH8; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR018154; TLV/ENV_coat_polyprotein.
DR PANTHER; PTHR10424; PTHR10424; 1.
DR Pfam; PF00429; TLV_coat; 1.
PE 2: Evidence at transcript level;
KW ERV; Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transposable element.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..477
FT /note="Endogenous retrovirus group V member 1 Env
FT polyprotein"
FT /id="PRO_0000411000"
FT TOPO_DOM 22..321
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 322..342
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 343..477
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 477 AA; 52557 MW; 90CD27A4D7B55129 CRC64;
MTEKFLFLYL SLLPMPLLSQ AQWNENSLVS FSKIIASGNH LSNCWICHNF ITRSSSYQYI
LVRNFSLNLT FGSGIPEGQH KSVPLQVSLA NSAHQVPCLD LTPPFNQSSK TSFYFYNCSS
LNQTCCPCPE GHCDRKNTSE EGFPSPTIHP MSFSPAGCHP NLTHWCPAKQ MNDYRDKSPQ
NRCAAWEGKE LITWRVLYLL PKAHTVPTWP KSTVPLGGPL SPACNQTIPA GWKSQLHKWF
DSHIPRWACT PPGYVFLCGP QKNKLPFDGS PKITYSTPPV ANLYTCINNI QHTGECAVGL
LGPRGIGVTI YNTTQPRQKR ALGLILAGMG AAIGMIAPWG GFTYHDVTLR NLSRQIDNIA
KSTRDSISKL KASIDSLANV VMNNRLALDY LLAEQGGVCA VISKSCCIYV NNSGAIEEDI
KKIYDEVTWL HNFGKGDSAG SIWEAVKSAL PSLTWFVPLL GPAALNSLLS PLWPLSL
