ERVV2_HUMAN
ID ERVV2_HUMAN Reviewed; 535 AA.
AC B6SEH9;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Endogenous retrovirus group V member 2 Env polyprotein;
DE AltName: Full=HERV-V_19q13.41 provirus ancestral Env polyprotein 2;
DE Flags: Precursor;
GN Name=ERVV-2; Synonyms=ENVV2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX PubMed=18826608; DOI=10.1186/1471-2148-8-266;
RA Kjeldbjerg A.L., Villesen P., Aagaard L., Pedersen F.S.;
RT "Gene conversion and purifying selection of a placenta-specific ERV-V
RT envelope gene during simian evolution.";
RL BMC Evol. Biol. 8:266-266(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in placenta.
CC {ECO:0000269|PubMed:18826608}.
CC -!- SIMILARITY: Belongs to the gamma type-C retroviral envelope protein
CC family. {ECO:0000305}.
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DR EMBL; EU853143; ACI62854.1; -; Genomic_DNA.
DR EMBL; AC010328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS59420.1; -.
DR RefSeq; NP_001177984.1; NM_001191055.1.
DR AlphaFoldDB; B6SEH9; -.
DR SMR; B6SEH9; -.
DR STRING; 9606.ENSP00000472919; -.
DR GlyGen; B6SEH9; 1 site.
DR iPTMnet; B6SEH9; -.
DR PhosphoSitePlus; B6SEH9; -.
DR BioMuta; ERVV-2; -.
DR PaxDb; B6SEH9; -.
DR PeptideAtlas; B6SEH9; -.
DR PRIDE; B6SEH9; -.
DR ProteomicsDB; 6249; -.
DR DNASU; 100271846; -.
DR Ensembl; ENST00000601417.3; ENSP00000472919.1; ENSG00000268964.3.
DR GeneID; 100271846; -.
DR KEGG; hsa:100271846; -.
DR MANE-Select; ENST00000601417.3; ENSP00000472919.1; NM_001191055.2; NP_001177984.1.
DR CTD; 100271846; -.
DR DisGeNET; 100271846; -.
DR GeneCards; ERVV-2; -.
DR HGNC; HGNC:39051; ERVV-2.
DR HPA; ENSG00000268964; Tissue enriched (placenta).
DR neXtProt; NX_B6SEH9; -.
DR VEuPathDB; HostDB:ENSG00000268964; -.
DR eggNOG; ENOG502SD08; Eukaryota.
DR GeneTree; ENSGT00940000164101; -.
DR HOGENOM; CLU_045261_0_0_1; -.
DR InParanoid; B6SEH9; -.
DR OMA; QNKLPYE; -.
DR OrthoDB; 389221at2759; -.
DR PhylomeDB; B6SEH9; -.
DR PathwayCommons; B6SEH9; -.
DR BioGRID-ORCS; 100271846; 17 hits in 977 CRISPR screens.
DR GenomeRNAi; 100271846; -.
DR Pharos; B6SEH9; Tdark.
DR PRO; PR:B6SEH9; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; B6SEH9; protein.
DR Bgee; ENSG00000268964; Expressed in placenta and 4 other tissues.
DR ExpressionAtlas; B6SEH9; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR018154; TLV/ENV_coat_polyprotein.
DR PANTHER; PTHR10424; PTHR10424; 1.
DR Pfam; PF00429; TLV_coat; 1.
PE 2: Evidence at transcript level;
KW ERV; Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transposable element.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..535
FT /note="Endogenous retrovirus group V member 2 Env
FT polyprotein"
FT /id="PRO_0000411001"
FT TOPO_DOM 22..321
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 322..342
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 343..456
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 478..535
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 535 AA; 59317 MW; 42A12AA10BC6D3A7 CRC64;
MTEKFLFLYL SLLPMPLLSQ AQWNENSLVS FSKIIASGNH LSNCWICHNF ITRSSSYQYI
LVRNFSLNLT FGSGIPEGQH KSVPLQVSLA NSAHQVPCLD LTPPFNQSSK TSFYFYNCSS
LNQTCCPCPE GHCDRKNTSE EGFPSPTIHP MSFSPAGCHP NLTHWCPAKQ MNDYRDKSPQ
NRCAAWEGKE LITWRVLYSL PKAHTVPTWP KSTVPLGGPL SPACNQTIPA GWKSQLHKWF
DSHIPRWACT PPGYVFLCGP QKNKLPFDGS PKITYSTPPV ANLYTCINNI QHTGECAVGL
LGPRGIGVTI YNTTQPRQKR ALGLILAGMG AAIGMIAPWG GFTYHDVTLR NLSRQIDNIA
KSTRDSISKL KASIDSLANV VMDNRLALDY LLAEQGGVCA VINKSCCVYV NNSGAIEEDI
KKIYDEATWL HDFGKGGASA RAIWEAVKSA LPSLNWFVPL LGPATVILLL FLFGPCFFNL
LIKCVSSRIK QFHMKSPQME RYQLSVIGGP STYKHISPLD ASGQRFRETM EEFSL
