AGRB_STAEP
ID AGRB_STAEP Reviewed; 194 AA.
AC P0C0N4; O68161; O86859;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Accessory gene regulator protein B {ECO:0000255|HAMAP-Rule:MF_00784};
DE EC=3.4.-.- {ECO:0000255|HAMAP-Rule:MF_00784};
GN Name=agrB {ECO:0000255|HAMAP-Rule:MF_00784};
OS Staphylococcus epidermidis.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=1282;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=0869.12.80;
RX PubMed=9631538; DOI=10.1111/j.1574-6968.1998.tb13018.x;
RA Van Wamel W.J.B., Rossum G., Verhoef J., Vandenbroucke-Grauls C.M.J.E.,
RA Fluit A.C.;
RT "Cloning and characterization of an accessory gene regulator (agr)-like
RT locus from Staphylococcus epidermidis.";
RL FEMS Microbiol. Lett. 163:1-9(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 14990 / DSM 20044 / CIP 81.55 / NCTC 11047;
RX PubMed=9537521; DOI=10.1016/s0014-5793(98)00145-8;
RA Otto M., Suszmuth R., Jung G., Goetz F.;
RT "Structure of the pheromone peptide of the Staphylococcus epidermidis agr
RT system.";
RL FEBS Lett. 424:89-94(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=O47;
RX PubMed=12934187; DOI=10.1086/377239;
RA Vuong C., Gerke C., Somerville G.A., Fischer E.R., Otto M.;
RT "Quorum-sensing control of biofilm factors in Staphylococcus epidermidis.";
RL J. Infect. Dis. 188:706-718(2003).
CC -!- FUNCTION: Essential for the production of a quorum sensing system
CC signal molecule, the autoinducing peptide (AIP). This quorum sensing
CC system is responsible for the regulation of the expression of virulence
CC factor genes. Involved in the proteolytic processing of AgrD, the
CC precursor of AIP. {ECO:0000255|HAMAP-Rule:MF_00784}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00784};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00784}.
CC -!- SIMILARITY: Belongs to the AgrB family. {ECO:0000255|HAMAP-
CC Rule:MF_00784}.
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DR EMBL; Z49220; CAA89193.1; -; Genomic_DNA.
DR EMBL; AF012132; AAC38295.1; -; Genomic_DNA.
DR EMBL; AY183373; AAO25549.1; -; Genomic_DNA.
DR RefSeq; WP_001830005.1; NZ_WLUZ01000001.1.
DR AlphaFoldDB; P0C0N4; -.
DR SMR; P0C0N4; -.
DR MEROPS; C75.001; -.
DR GeneID; 50018265; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00784; AgrB; 1.
DR InterPro; IPR006741; AgrB.
DR Pfam; PF04647; AgrB; 1.
DR SMART; SM00793; AgrB; 1.
PE 3: Inferred from homology;
KW Cell membrane; Hydrolase; Membrane; Protease; Quorum sensing;
KW Transmembrane; Transmembrane helix; Virulence.
FT CHAIN 1..194
FT /note="Accessory gene regulator protein B"
FT /id="PRO_0000168126"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT CONFLICT 13..16
FT /note="QYLQ -> HIYNV (in Ref. 2; AAC38295)"
FT /evidence="ECO:0000305"
FT CONFLICT 192
FT /note="K -> N (in Ref. 2; AAC38295)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 194 AA; 22573 MW; 75076CD3DF62861A CRC64;
MKIIDKKIEQ FAQYLQRKNN LDHIQFLKIR LGMQVLAINI EKSIVVYGLA IIFHTFFYTL
LTHLSYFLIR RHAHGTHANS SLLCHIQNII FFIIFPYLII KLDINYFVLL SMALVGLIIT
ILYAPAATKK QPIPRRLVKR KKILSIFLYC TIVVISLVTK EPVNKLILFG VILESLTLLP
IFFPKEDINH GKHF
